RS28_MOUSE
ID RS28_MOUSE Reviewed; 69 AA.
AC P62858; P25112; Q5BKQ7;
DT 16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=40S ribosomal protein S28;
GN Name=Rps28;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Yotov W.V., St Arnaud R.;
RT "Cloning of mouse cDNA for ribosomal protein S28.";
RL Submitted (JUN-1994) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RA Rowen L., Qin S., Madan A., Loretz C., Hall J., James R., Dors M.,
RA Shaffer T., Abbasi N., Ratcliffe A., Dickhoff R., Lasky S., Hood L.;
RT "Sequence of the mouse major histocompatibility complex class II region.";
RL Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129/Sv;
RA Brathwaite M.E., Waeltz P., Qian Y., Dudekula D., Schlessinger D.,
RA Nagaraja R.;
RT "Genomic sequence analysis in the mouse T-complex region.";
RL Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Component of the 40S small ribosomal subunit.
CC {ECO:0000250|UniProtKB:Q6QAT1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000250|UniProtKB:P62857}. Cytoplasm
CC {ECO:0000250|UniProtKB:P62857}. Rough endoplasmic reticulum
CC {ECO:0000250|UniProtKB:Q6QAT1}. Note=Detected on cytosolic polysomes
CC (By similarity). Detected in ribosomes that are associated with the
CC rough endoplasmic reticulum (By similarity).
CC {ECO:0000250|UniProtKB:P62857, ECO:0000250|UniProtKB:Q6QAT1}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS28 family.
CC {ECO:0000305}.
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DR EMBL; U11248; AAA19605.1; -; mRNA.
DR EMBL; AK002919; BAB22456.1; -; mRNA.
DR EMBL; AF110520; AAC97967.1; -; Genomic_DNA.
DR EMBL; AF528162; AAO17375.1; -; Genomic_DNA.
DR EMBL; BC010987; AAH10987.1; -; mRNA.
DR EMBL; BC090982; AAH90982.1; -; mRNA.
DR CCDS; CCDS37571.1; -.
DR RefSeq; NP_058540.1; NM_016844.2.
DR RefSeq; XP_006524687.1; XM_006524624.3.
DR PDB; 7CPU; EM; 2.82 A; Sc=1-69.
DR PDB; 7CPV; EM; 3.03 A; Sc=1-69.
DR PDB; 7LS1; EM; 3.30 A; G3=1-69.
DR PDB; 7LS2; EM; 3.10 A; G3=1-69.
DR PDBsum; 7CPU; -.
DR PDBsum; 7CPV; -.
DR PDBsum; 7LS1; -.
DR PDBsum; 7LS2; -.
DR AlphaFoldDB; P62858; -.
DR SMR; P62858; -.
DR BioGRID; 207567; 78.
DR ComplexPortal; CPX-5261; 40S cytosolic small ribosomal subunit.
DR IntAct; P62858; 1.
DR STRING; 10090.ENSMUSP00000110013; -.
DR iPTMnet; P62858; -.
DR PhosphoSitePlus; P62858; -.
DR SwissPalm; P62858; -.
DR EPD; P62858; -.
DR jPOST; P62858; -.
DR PaxDb; P62858; -.
DR PeptideAtlas; P62858; -.
DR PRIDE; P62858; -.
DR ProteomicsDB; 262734; -.
DR Antibodypedia; 24844; 82 antibodies from 20 providers.
DR DNASU; 54127; -.
DR Ensembl; ENSMUST00000087342; ENSMUSP00000110013; ENSMUSG00000067288.
DR Ensembl; ENSMUST00000166693; ENSMUSP00000133642; ENSMUSG00000067288.
DR Ensembl; ENSMUST00000173019; ENSMUSP00000134615; ENSMUSG00000067288.
DR Ensembl; ENSMUST00000173844; ENSMUSP00000133357; ENSMUSG00000067288.
DR GeneID; 54127; -.
DR KEGG; mmu:54127; -.
DR UCSC; uc008bzs.2; mouse.
DR CTD; 6234; -.
DR MGI; MGI:1859516; Rps28.
DR VEuPathDB; HostDB:ENSMUSG00000067288; -.
DR eggNOG; KOG3502; Eukaryota.
DR GeneTree; ENSGT00910000144227; -.
DR InParanoid; P62858; -.
DR OMA; MHGEASQ; -.
DR OrthoDB; 1578965at2759; -.
DR PhylomeDB; P62858; -.
DR TreeFam; TF300136; -.
DR Reactome; R-MMU-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-MMU-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-MMU-72649; Translation initiation complex formation.
DR Reactome; R-MMU-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-MMU-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-MMU-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-MMU-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-MMU-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-MMU-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR BioGRID-ORCS; 54127; 29 hits in 73 CRISPR screens.
DR ChiTaRS; Rps28; mouse.
DR PRO; PR:P62858; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; P62858; protein.
DR Bgee; ENSMUSG00000067288; Expressed in yolk sac and 64 other tissues.
DR ExpressionAtlas; P62858; baseline and differential.
DR Genevisible; P62858; MM.
DR GO; GO:0005737; C:cytoplasm; IC:ComplexPortal.
DR GO; GO:0098556; C:cytoplasmic side of rough endoplasmic reticulum membrane; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISS:UniProtKB.
DR GO; GO:0042788; C:polysomal ribosome; ISS:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:MGI.
DR GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR GO; GO:0030490; P:maturation of SSU-rRNA; IBA:GO_Central.
DR GO; GO:0000028; P:ribosomal small subunit assembly; IBA:GO_Central.
DR GO; GO:0042274; P:ribosomal small subunit biogenesis; ISO:MGI.
DR GO; GO:0042254; P:ribosome biogenesis; ISS:UniProtKB.
DR GO; GO:0006364; P:rRNA processing; ISO:MGI.
DR CDD; cd04457; S1_S28E; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR HAMAP; MF_00292; Ribosomal_S28e; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR000289; Ribosomal_S28e.
DR InterPro; IPR028626; Ribosomal_S28e_CS.
DR PANTHER; PTHR10769; PTHR10769; 1.
DR Pfam; PF01200; Ribosomal_S28e; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS00961; RIBOSOMAL_S28E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cytoplasm; Endoplasmic reticulum;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..69
FT /note="40S ribosomal protein S28"
FT /id="PRO_0000136823"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:P62859"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P62857"
SQ SEQUENCE 69 AA; 7841 MW; 49902FE9376EB74F CRC64;
MDTSRVQPIK LARVTKVLGR TGSQGQCTQV RVEFMDDTSR SIIRNVKGPV REGDVLTLLE
SEREARRLR
