BACH_HALSA
ID BACH_HALSA Reviewed; 274 AA.
AC P0DMH7; P16102; Q9HSK9;
DT 14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 1.
DT 03-AUG-2022, entry version 34.
DE RecName: Full=Halorhodopsin;
DE Short=HR;
DE Flags: Precursor;
GN Name=hop; OrderedLocusNames=VNG_0180G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: Light-driven chloride pump. {ECO:0000250}.
CC -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the archaeal/bacterial/fungal opsin family.
CC {ECO:0000305}.
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DR EMBL; AE004437; AAG18795.1; -; Genomic_DNA.
DR PIR; G84178; G84178.
DR RefSeq; WP_010902090.1; NC_002607.1.
DR AlphaFoldDB; P0DMH7; -.
DR SMR; P0DMH7; -.
DR STRING; 64091.VNG_0180G; -.
DR PaxDb; P0DMH7; -.
DR EnsemblBacteria; AAG18795; AAG18795; VNG_0180G.
DR GeneID; 5952411; -.
DR GeneID; 62883752; -.
DR KEGG; hal:VNG_0180G; -.
DR PATRIC; fig|64091.14.peg.132; -.
DR HOGENOM; CLU_054785_5_1_2; -.
DR OMA; VCRQVFW; -.
DR OrthoDB; 70686at2157; -.
DR PhylomeDB; P0DMH7; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR InterPro; IPR001425; Arc/bac/fun_rhodopsins.
DR InterPro; IPR018229; Rhodopsin_retinal_BS.
DR PANTHER; PTHR28286; PTHR28286; 1.
DR Pfam; PF01036; Bac_rhodopsin; 1.
DR PRINTS; PR00251; BACTRLOPSIN.
DR SMART; SM01021; Bac_rhodopsin; 1.
DR PROSITE; PS00950; BACTERIAL_OPSIN_1; 1.
DR PROSITE; PS00327; BACTERIAL_OPSIN_RET; 1.
PE 3: Inferred from homology;
KW Cell membrane; Chloride; Chromophore; Ion transport; Membrane;
KW Photoreceptor protein; Receptor; Reference proteome; Retinal protein;
KW Sensory transduction; Transmembrane; Transmembrane helix; Transport.
FT PROPEP 1..21
FT /evidence="ECO:0000250"
FT /id="PRO_0000020238"
FT CHAIN 22..274
FT /note="Halorhodopsin"
FT /id="PRO_0000020239"
FT TOPO_DOM 22..25
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 26..51
FT /note="Helical; Name=Helix A"
FT /evidence="ECO:0000250"
FT TOPO_DOM 52..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 58..81
FT /note="Helical; Name=Helix B"
FT /evidence="ECO:0000250"
FT TOPO_DOM 82..105
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 106..127
FT /note="Helical; Name=Helix C"
FT /evidence="ECO:0000250"
FT TOPO_DOM 128..130
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 131..154
FT /note="Helical; Name=Helix D"
FT /evidence="ECO:0000250"
FT TOPO_DOM 155..157
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 158..180
FT /note="Helical; Name=Helix E"
FT /evidence="ECO:0000250"
FT TOPO_DOM 181..192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 193..216
FT /note="Helical; Name=Helix F"
FT /evidence="ECO:0000250"
FT TOPO_DOM 217..226
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 227..255
FT /note="Helical; Name=Helix G"
FT /evidence="ECO:0000250"
FT TOPO_DOM 256..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT MOD_RES 242
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 274 AA; 28874 MW; 8FEDBBEDC717CD6B CRC64;
MSITSVPGVV DAGVLGAQSA AAVRENALLS SSLWVNVALA GIAILVFVYM GRTIRPGRPR
LIWGATLMIP LVSISSYLGL LSGLTVGMIE MPAGHALAGE MVRSQWGRYL TWALSTPMIL
LALGLLADVD LGSLFTVIAA DIGMCVTGLA AAMTTSALLF RWAFYAISCA FFVVVLSALV
TDWAASASSA GTAEIFDTLR VLTVVLWLGY PIVWAVGVEG LALVQSVGVT SWAYSVLDVF
AKYVFAFILL RWVANNERTV AVAGQTLGTM SSDD
