ID   BACH_HALSS              Reviewed;         284 AA.
AC   P33742;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Halorhodopsin;
DE            Short=HR;
GN   Name=hop;
OS   Halobacterium sp. (strain SG1).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=33006;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8478333; DOI=10.1128/jb.175.9.2720-2726.1993;
RA   Soppa J., Duschl J., Oesterhelt D.;
RT   "Bacterioopsin, haloopsin, and sensory opsin I of the halobacterial isolate
RT   Halobacterium sp. strain SG1: three new members of a growing family.";
RL   J. Bacteriol. 175:2720-2726(1993).
CC   -!- FUNCTION: Light-driven chloride pump.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the archaeal/bacterial/fungal opsin family.
CC       {ECO:0000305}.
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DR   EMBL; X70292; CAA49773.1; -; Genomic_DNA.
DR   PIR; S78781; S29988.
DR   AlphaFoldDB; P33742; -.
DR   SMR; P33742; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001425; Arc/bac/fun_rhodopsins.
DR   InterPro; IPR018229; Rhodopsin_retinal_BS.
DR   PANTHER; PTHR28286; PTHR28286; 1.
DR   Pfam; PF01036; Bac_rhodopsin; 1.
DR   PRINTS; PR00251; BACTRLOPSIN.
DR   SMART; SM01021; Bac_rhodopsin; 1.
DR   PROSITE; PS00950; BACTERIAL_OPSIN_1; 1.
DR   PROSITE; PS00327; BACTERIAL_OPSIN_RET; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chromophore; Ion transport; Membrane;
KW   Photoreceptor protein; Receptor; Retinal protein; Sensory transduction;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..284
FT                   /note="Halorhodopsin"
FT                   /id="PRO_0000196265"
FT   TOPO_DOM        1..30
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        31..56
FT                   /note="Helical; Name=Helix A"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        57..62
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        63..86
FT                   /note="Helical; Name=Helix B"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        87..110
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        111..132
FT                   /note="Helical; Name=Helix C"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        133..135
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        136..159
FT                   /note="Helical; Name=Helix D"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        160..162
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        163..185
FT                   /note="Helical; Name=Helix E"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        186..197
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        198..221
FT                   /note="Helical; Name=Helix F"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        222..230
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        231..259
FT                   /note="Helical; Name=Helix G"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        260..284
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         246
FT                   /note="N6-(retinylidene)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   284 AA;  30256 MW;  2C659F0A69D5CA13 CRC64;
     MIETAAADIL AGGMVPLEMT QTQIFEAVQS DTLLASSLWI NIALAGLSIL LFVYMGRNVE
     DPRAQLIFVA TLMVPLVSIS SYTGLVSGLT VSFLEMPAGH ALAGQEVLTP WGRYLTWALS
     TPMILIAVGL LAGSNTTKLF TAVVADIGMC VTGLAAALTT SSYLLRWVWY AISCAFFVVV
     LYILLAEWAE DAEIAGTADI FNTLKVLTVV LWLGYPIFWA LGAEGLAVLD VAITSWAYSG
     MDIVAKYLFA FLLLRWVVNN ERTVADVASG LGSGSRGGAA PADD