ID   BACH_HALVA              Reviewed;         276 AA.
AC   P94853;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Cruxhalorhodopsin-3;
DE            Short=CHR-3;
DE   Flags: Precursor;
GN   Name=choP3;
OS   Haloarcula vallismortis (Halobacterium vallismortis).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Haloarculaceae; Haloarcula.
OX   NCBI_TaxID=28442;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 29715 / DSM 3756 / JCM 8877 / NBRC 14741 / NCIMB 2082;
RX   PubMed=8645307; DOI=10.1006/bbrc.1996.0407;
RA   Kitajima T., Hirayama J., Ihara K., Sugiyama Y., Kamo N., Mukohata Y.;
RT   "Novel bacterial rhodopsins from Haloarcula vallismortis.";
RL   Biochem. Biophys. Res. Commun. 220:341-345(1996).
CC   -!- FUNCTION: Light-driven chloride pump.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the archaeal/bacterial/fungal opsin family.
CC       {ECO:0000305}.
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DR   EMBL; D31881; BAA06679.1; -; Genomic_DNA.
DR   PIR; T48842; T48842.
DR   RefSeq; WP_004517017.1; NZ_FNOF01000005.1.
DR   AlphaFoldDB; P94853; -.
DR   SMR; P94853; -.
DR   STRING; 28442.SAMN05443574_10584; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR   InterPro; IPR001425; Arc/bac/fun_rhodopsins.
DR   InterPro; IPR018229; Rhodopsin_retinal_BS.
DR   PANTHER; PTHR28286; PTHR28286; 1.
DR   Pfam; PF01036; Bac_rhodopsin; 1.
DR   PRINTS; PR00251; BACTRLOPSIN.
DR   SMART; SM01021; Bac_rhodopsin; 1.
DR   PROSITE; PS00950; BACTERIAL_OPSIN_1; 1.
DR   PROSITE; PS00327; BACTERIAL_OPSIN_RET; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Chloride; Chromophore; Ion transport; Membrane;
KW   Photoreceptor protein; Receptor; Retinal protein; Sensory transduction;
KW   Transmembrane; Transmembrane helix; Transport.
FT   PROPEP          1..21
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000020244"
FT   CHAIN           22..276
FT                   /note="Cruxhalorhodopsin-3"
FT                   /id="PRO_0000020245"
FT   TOPO_DOM        22..25
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        26..51
FT                   /note="Helical; Name=Helix A"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        52..57
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        58..81
FT                   /note="Helical; Name=Helix B"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        82..105
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        106..127
FT                   /note="Helical; Name=Helix C"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        128..130
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        131..154
FT                   /note="Helical; Name=Helix D"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        155..157
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        158..180
FT                   /note="Helical; Name=Helix E"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        181..192
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        193..216
FT                   /note="Helical; Name=Helix F"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        217..225
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250"
FT   TRANSMEM        226..254
FT                   /note="Helical; Name=Helix G"
FT                   /evidence="ECO:0000250"
FT   TOPO_DOM        255..276
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         241
FT                   /note="N6-(retinylidene)lysine"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   276 AA;  29116 MW;  9EDAB70895778BB2 CRC64;
     MPAASTAATT LLQASQSEVL GEIQSNFLLN SSLWVNIALA GVVILLFVAM GRELESSRAK
     LIWVATMLVP LVSISSYAGL ASGLTVGFLQ MPPGHALAGQ EVLSPWGRYL TWTFSTPMIL
     LALGLLADTD MASLFTAITM DIGMCITGLA AALVTSSHLL RWVFYGISCA FFIAVLYVLL
     VEWPADAEAA GTSEIFGTLK LLTVVLWLGY PILWALGSEG VALLSVGVTS WGYSGLDILA
     KYVFAFLLLR WVAANEDTVT QAGMSLGSGG AAPADD