ABCA5_DICDI
ID ABCA5_DICDI Reviewed; 1662 AA.
AC Q8T6J2; Q555N5; Q8T162;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=ABC transporter A family member 5;
DE AltName: Full=ABC transporter ABCA.5;
GN Name=abcA5; ORFNames=DDB_G0274119;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AF465307; AAL85298.1; -; Genomic_DNA.
DR EMBL; AC123513; AAM44362.1; -; Genomic_DNA.
DR EMBL; AAFI02000012; EAL69952.1; -; Genomic_DNA.
DR RefSeq; XP_644031.1; XM_638939.1.
DR AlphaFoldDB; Q8T6J2; -.
DR SMR; Q8T6J2; -.
DR STRING; 44689.DDB0191224; -.
DR PaxDb; Q8T6J2; -.
DR EnsemblProtists; EAL69952; EAL69952; DDB_G0274119.
DR GeneID; 8619461; -.
DR KEGG; ddi:DDB_G0274119; -.
DR dictyBase; DDB_G0274119; abcA5.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; Q8T6J2; -.
DR OMA; CLFICIA; -.
DR PhylomeDB; Q8T6J2; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8963896; HDL assembly.
DR PRO; PR:Q8T6J2; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1662
FT /note="ABC transporter A family member 5"
FT /id="PRO_0000363837"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 284..304
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 872..892
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1052..1072
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1102..1122
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1130..1150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1163..1183
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1201..1221
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1246..1266
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 505..739
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1322..1557
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 541..548
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1360..1367
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1662 AA; 185773 MW; F4D61AC43E08855B CRC64;
MGEKSSQLKT LLKKNLLLKS KSKCGICCEI VFPIIIVLLV FAILVLVQLF KPNYDLIKTT
QFSNRINENN IIIYGGKAGS LNVEQKGVID MMKFQLSNEL NKSISEVDVY FKEINDKSEM
ENYFQINSTQ VFGGIWFESN QLSSVANTTN TNTTTNSFKY SIRLDSNSVL DSNKVKDNGI
DSSDYLTKNW AYIQIAMDQA IFGYFGLDYK LVINGQRYPD PYVELWQKWI NGRESVFKSA
GSVFVSAALL IFTFRLVTEL VVEKETKIRE GMSIMGLNQY CYFISWIITS LVTALPIDLI
IIVILKGSQV IHSTSWIIVI VTLILYLLTL QLLAFIFSMF FDKSKFAGLL TFLTILLINI
CGIFIGEYEI INIHIKLLLC CIFSPIGIAC SFYIMSIRDI PDTISTINLN QVISEKQIIG
TFVFNIIFYT FLIWYLDKIV KTEYGTKEPW YFLFTKRYWT VGAGKINKKN KNKEYNYNDI
ESTIQNNNND NIEMVPIEVR NKTTISIRNL RKEFKTGDGL RIAVNDLNLD MFDGQIHGLL
GPNGSGKSTT ISMLTGLLSP TSGTAFILGN DITYQMNEIR KCTGVCLQTD IIWNQLTVLE
HLEIYASLKG ITNKKQIKSE SLKMANEIDL GEKLHTPAGS LSGGQKRKLC LGIAFIGRST
IIFLDEVSSG MDPSSRRKVW DFLLSHKKGK TIILTTHYLD EADYLSDRIS IISHGKLITD
GSSLFLKNKY GVGYLLTCSK SLNTIDQFNV DQVTQFIRDQ IPDVTVLSNA GSEISFRLPT
ASLPVFSKFF KDFDENLSNF HIDSYGISVT TLEEVFLKIG TDIDTDALSI ADGNGNDDEL
KRSIGVSSTG IKSKQQLKAL LIKRVKTSSK DFKAFLLSLL LPLLVIIGSI IVFKEVDNEV
IFYNNSTEPL TFSLLQQYGK NDIVPIQLAG TTSEFDFNKF LSNSPYFNQF QYLNNSINFN
QYLINNYKQS SGSINFTIPL SSSLINNTTK VISYNSLFNF NYIHSWPVHV NLINDALLRN
HNGIGIECTS LPFDHILTSF QKASQGMNIQ SIVYFIVIMM AGFSLMAGSF AGSISQERTN
RIKRLLYISG CKKYIYWVSN LLWDYFFAFI LLLITCIILA IVDDKFNDQF GLFFLSLVLF
SLSIIPLSYL FSFKFSSFGK STGAITAIHF SIGVIMTIAM IILRIEVIIK NSSSLENIAD
IIDIVFNILS PLYAFSRVIF IISGFPGSLR LGALKIDDYW SLHYASTPII ILSVHVVVWT
IFILLIDYSP EFKGYLRNPK TILPPPPPID EDSDVSAERI RLESMSPIPS TDQGSGGGGD
MLQYKGLHKL FIGKGKNPNK NAVYNSTLGI PQGQTFGLLG LNGAGKTTTV SMLAGDILPT
SGQITINGHD LVTDRAQALR GVSVCPQFDA LITLLTAREQ LSLYCAIKGV PDDKISLVVE
AFIKMMDLGK IANSNTGGYS GGNKRKVSLS IAMLGNPSVV LIDEASSGCD PIIRYRQCQV
ISELGKNKVI ILTSHSMSEI QALCSRMTIM RDGQFKCLGS TQHIKSKFGA GYSVEVKFKK
SCLEVGIPQS LQCVLECFPN ATILDQHDLM ASLELPNPPE NPIKVSEIFN ILSTELSSIL
DDYSVSQTSL EQVFLKLTGA THEDRLNLNN QQQQQQTIPN SD
