BACR3_HALSD
ID BACR3_HALSD Reviewed; 258 AA.
AC P96787;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Archaerhodopsin-3;
DE Short=AR 3;
DE Flags: Precursor;
GN Name=aop3;
OS Halorubrum sodomense.
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales;
OC Halorubraceae; Halorubrum.
OX NCBI_TaxID=35743;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9878396; DOI=10.1006/jmbi.1998.2286;
RA Ihara K., Umemura T., Katagiri I., Kitajima-Ihara T., Sugiyama Y.,
RA Kimura Y., Mukohata Y.;
RT "Evolution of the archaeal rhodopsins: evolution rate changes by gene
RT duplication and functional differentiation.";
RL J. Mol. Biol. 285:163-174(1999).
CC -!- FUNCTION: Light-driven proton pump.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the archaeal/bacterial/fungal opsin family.
CC {ECO:0000305}.
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DR EMBL; D50848; BAA09452.1; -; Genomic_DNA.
DR PIR; T50676; T50676.
DR PDB; 6GUX; X-ray; 1.30 A; A=7-247.
DR PDB; 6GUY; X-ray; 2.20 A; A=7-247.
DR PDB; 6GUZ; X-ray; 1.90 A; A=8-247.
DR PDB; 6S63; X-ray; 1.85 A; A=7-247.
DR PDB; 6S6C; X-ray; 1.07 A; A=7-247.
DR PDBsum; 6GUX; -.
DR PDBsum; 6GUY; -.
DR PDBsum; 6GUZ; -.
DR PDBsum; 6S63; -.
DR PDBsum; 6S6C; -.
DR AlphaFoldDB; P96787; -.
DR SMR; P96787; -.
DR STRING; 35743.SAMN04487937_1688; -.
DR TCDB; 3.E.1.1.4; the ion-translocating microbial rhodopsin (mr) family.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR GO; GO:0009881; F:photoreceptor activity; IEA:UniProtKB-KW.
DR GO; GO:0007602; P:phototransduction; IEA:UniProtKB-KW.
DR InterPro; IPR001425; Arc/bac/fun_rhodopsins.
DR InterPro; IPR018229; Rhodopsin_retinal_BS.
DR PANTHER; PTHR28286; PTHR28286; 1.
DR Pfam; PF01036; Bac_rhodopsin; 1.
DR PRINTS; PR00251; BACTRLOPSIN.
DR SMART; SM01021; Bac_rhodopsin; 1.
DR PROSITE; PS00950; BACTERIAL_OPSIN_1; 1.
DR PROSITE; PS00327; BACTERIAL_OPSIN_RET; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; Chromophore; Hydrogen ion transport;
KW Ion transport; Membrane; Photoreceptor protein;
KW Pyrrolidone carboxylic acid; Receptor; Retinal protein;
KW Sensory transduction; Transmembrane; Transmembrane helix; Transport.
FT PROPEP 1..6
FT /evidence="ECO:0000250"
FT /id="PRO_0000020254"
FT CHAIN 7..258
FT /note="Archaerhodopsin-3"
FT /id="PRO_0000020255"
FT TOPO_DOM 7..18
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 19..40
FT /note="Helical; Name=Helix A"
FT /evidence="ECO:0000250"
FT TOPO_DOM 41..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 50..71
FT /note="Helical; Name=Helix B"
FT /evidence="ECO:0000250"
FT TOPO_DOM 72..89
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 90..111
FT /note="Helical; Name=Helix C"
FT /evidence="ECO:0000250"
FT TOPO_DOM 112..114
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 115..137
FT /note="Helical; Name=Helix D"
FT /evidence="ECO:0000250"
FT TOPO_DOM 138..141
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 142..170
FT /note="Helical; Name=Helix E"
FT /evidence="ECO:0000250"
FT TOPO_DOM 171..173
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT TRANSMEM 174..202
FT /note="Helical; Name=Helix F"
FT /evidence="ECO:0000250"
FT TOPO_DOM 203..210
FT /note="Extracellular"
FT /evidence="ECO:0000250"
FT TRANSMEM 211..243
FT /note="Helical; Name=Helix G"
FT /evidence="ECO:0000250"
FT TOPO_DOM 244..258
FT /note="Cytoplasmic"
FT /evidence="ECO:0000250"
FT MOD_RES 7
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000250"
FT MOD_RES 226
FT /note="N6-(retinylidene)lysine"
FT /evidence="ECO:0000250"
FT STRAND 14..16
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 20..42
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 47..72
FT /evidence="ECO:0007829|PDB:6S6C"
FT TURN 73..75
FT /evidence="ECO:0007829|PDB:6S6C"
FT STRAND 76..81
FT /evidence="ECO:0007829|PDB:6S6C"
FT STRAND 84..89
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 90..111
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 115..136
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 141..163
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 165..171
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 175..201
FT /evidence="ECO:0007829|PDB:6S6C"
FT TURN 203..206
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 211..234
FT /evidence="ECO:0007829|PDB:6S6C"
FT HELIX 237..240
FT /evidence="ECO:0007829|PDB:6S6C"
SQ SEQUENCE 258 AA; 27746 MW; CA550C4C9941D382 CRC64;
MDPIALQAGY DLLGDGRPET LWLGIGTLLM LIGTFYFLVR GWGVTDKDAR EYYAVTILVP
GIASAAYLSM FFGIGLTEVT VGGEMLDIYY ARYADWLFTT PLLLLDLALL AKVDRVTIGT
LVGVDALMIV TGLIGALSHT AIARYSWWLF STICMIVVLY FLATSLRSAA KERGPEVAST
FNTLTALVLV LWTAYPILWI IGTEGAGVVG LGIETLLFMV LDVTAKVGFG FILLRSRAIL
GDTEAPEPSA GADVSAAD
