RS2_CAEEL
ID RS2_CAEEL Reviewed; 272 AA.
AC P51403;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=40S ribosomal protein S2;
GN Name=rps-2; ORFNames=C49H3.11;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Component of the ribosome, a large ribonucleoprotein complex
CC responsible for the synthesis of proteins in the cell. The small
CC ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the
CC encoded message by selecting cognate aminoacyl-transfer RNA (tRNA)
CC molecules. The large subunit (LSU) contains the ribosomal catalytic
CC site termed the peptidyl transferase center (PTC), which catalyzes the
CC formation of peptide bonds, thereby polymerizing the amino acids
CC delivered by tRNAs into a polypeptide chain. The nascent polypeptides
CC leave the ribosome through a tunnel in the LSU and interact with
CC protein factors that function in enzymatic processing, targeting, and
CC the membrane insertion of nascent chains at the exit of the ribosomal
CC tunnel. Plays a role in the assembly and function of the 40S ribosomal
CC subunit. Mutations in this protein affects the control of translational
CC fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and
CC ribosome assembly. {ECO:0000250|UniProtKB:P25443}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS5 family.
CC {ECO:0000305}.
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DR EMBL; FO080908; CCD67711.1; -; Genomic_DNA.
DR PIR; T34184; T34184.
DR RefSeq; NP_501322.1; NM_068921.5.
DR AlphaFoldDB; P51403; -.
DR SMR; P51403; -.
DR BioGRID; 42699; 98.
DR DIP; DIP-25206N; -.
DR IntAct; P51403; 3.
DR MINT; P51403; -.
DR STRING; 6239.C49H3.11.1; -.
DR iPTMnet; P51403; -.
DR EPD; P51403; -.
DR PaxDb; P51403; -.
DR PeptideAtlas; P51403; -.
DR EnsemblMetazoa; C49H3.11.1; C49H3.11.1; WBGene00004471.
DR EnsemblMetazoa; C49H3.11.2; C49H3.11.2; WBGene00004471.
DR GeneID; 177583; -.
DR KEGG; cel:CELE_C49H3.11; -.
DR UCSC; C49H3.11.1; c. elegans.
DR CTD; 177583; -.
DR WormBase; C49H3.11; CE04237; WBGene00004471; rps-2.
DR eggNOG; KOG0877; Eukaryota.
DR GeneTree; ENSGT00940000153095; -.
DR HOGENOM; CLU_065898_0_2_1; -.
DR InParanoid; P51403; -.
DR OMA; DLKNWVP; -.
DR OrthoDB; 1197354at2759; -.
DR PhylomeDB; P51403; -.
DR Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-CEL-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-CEL-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; P51403; -.
DR PRO; PR:P51403; -.
DR Proteomes; UP000001940; Chromosome IV.
DR Bgee; WBGene00004471; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR Gene3D; 3.30.230.10; -; 1.
DR InterPro; IPR000851; Ribosomal_S5.
DR InterPro; IPR005324; Ribosomal_S5_C.
DR InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
DR InterPro; IPR014721; Ribosomal_S5_D2-typ_fold_subgr.
DR InterPro; IPR005711; Ribosomal_S5_euk/arc.
DR InterPro; IPR013810; Ribosomal_S5_N.
DR InterPro; IPR018192; Ribosomal_S5_N_CS.
DR PANTHER; PTHR13718; PTHR13718; 1.
DR Pfam; PF00333; Ribosomal_S5; 1.
DR Pfam; PF03719; Ribosomal_S5_C; 1.
DR SUPFAM; SSF54211; SSF54211; 1.
DR TIGRFAMs; TIGR01020; uS5_euk_arch; 1.
DR PROSITE; PS00585; RIBOSOMAL_S5; 1.
DR PROSITE; PS50881; S5_DSRBD; 1.
PE 3: Inferred from homology;
KW Reference proteome; Repeat; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..272
FT /note="40S ribosomal protein S2"
FT /id="PRO_0000131677"
FT DOMAIN 98..161
FT /note="S5 DRBM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00268"
FT REGION 1..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 272 AA; 28960 MW; 60049F6B7DB8CB34 CRC64;
MADRGGFQSG FGGRGGGRGG ARPAGDRPAG RGGRGGRGGR GGRGGRAGRG GEKETEWTPV
TKLGRLVKEK KITTLEEIYL NSLPIKEFEI IDALCSNLKD EVLKISPVQK QTTAGQRTRF
KAFVAIGDHA GHVGLGVKCS KEVATAIRGA IVAAKLAVVP VRRGYWGNKI GLPHTVPCKV
TGKCASVMVR LIPAPRGTGI VSAPVPKKLL HMAGIEDCYT AAKGSTATLG NFAKATYAAL
QRTYSYLTPD LWKEEALEKS PYQRHHEYLA RN
