ID   BACT_STRMG              Reviewed;          25 AA.
AC   P86386;
DT   23-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-SEP-2018, sequence version 2.
DT   29-SEP-2021, entry version 21.
DE   RecName: Full=Bacteriocin mutacin F-59.1;
OS   Streptococcus mutans.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1309;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, AND MASS SPECTROMETRY.
RC   STRAIN=59.1 {ECO:0000269|PubMed:21477375};
RX   PubMed=21477375; DOI=10.1186/1471-2180-11-69;
RA   Nicolas G.G., LaPointe G., Lavoie M.C.;
RT   "Production, purification, sequencing and activity spectra of mutacins D-
RT   123.1 and F-59.1.";
RL   BMC Microbiol. 11:69-69(2011).
CC   -!- FUNCTION: Bactericidal activity against a wide range of pathogenic
CC       bacteria, including Bacillus spp., Enterococcus spp., Listeria spp.,
CC       Staphylococcus spp. and Streptococcus spp (PubMed:21477375). Has no
CC       activity against Lactobacillus salivarius, Staphylococcus aureus,
CC       Streptococcus pyogenes and Streptococcus suis (PubMed:21477375).
CC       {ECO:0000269|PubMed:21477375}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P29430}.
CC   -!- MASS SPECTROMETRY: Mass=2720; Mass_error=2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:21477375};
CC   -!- SIMILARITY: Belongs to the bacteriocin class IIA/YGNGV family.
CC       {ECO:0000255}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019835; P:cytolysis; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.130; -; 1.
DR   InterPro; IPR002633; Bacteriocin_IIa.
DR   InterPro; IPR023388; Bacteriocin_IIa_dom_sf.
DR   Pfam; PF01721; Bacteriocin_II; 1.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Bacteriocin; Direct protein sequencing;
KW   Disulfide bond; Secreted.
FT   CHAIN           1..25
FT                   /note="Bacteriocin mutacin F-59.1"
FT                   /id="PRO_0000392471"
FT   DISULFID        9..14
FT                   /evidence="ECO:0000250|UniProtKB:P29430"
FT   UNSURE          14
FT                   /note="Assigned by similarity to orthologs"
FT                   /evidence="ECO:0000305|PubMed:21477375"
FT   UNSURE          19
FT                   /note="Assigned by similarity to orthologs"
FT                   /evidence="ECO:0000305|PubMed:21477375"
FT   UNSURE          21
FT                   /note="Assigned by similarity to orthologs"
FT                   /evidence="ECO:0000305|PubMed:21477375"
FT   UNSURE          23..25
FT                   /note="Assigned by similarity to orthologs"
FT                   /evidence="ECO:0000305|PubMed:21477375"
SQ   SEQUENCE   25 AA;  2728 MW;  14B29B2253A80D0C CRC64;
     KYYGNGVTCG KHSXSVDWSK ATTNI