BAD1_ARATH
ID BAD1_ARATH Reviewed; 426 AA.
AC Q8GYH5; Q9FIU3;
DT 18-JAN-2017, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Ankyrin repeat-containing protein BDA1 {ECO:0000305};
DE AltName: Full=Protein BIAN DA 1 {ECO:0000303|PubMed:22740615};
GN Name=BAD1 {ECO:0000303|PubMed:22740615};
GN OrderedLocusNames=At5g54610 {ECO:0000312|Araport:AT5G54610};
GN ORFNames=MRB17.11 {ECO:0000312|EMBL:BAB09340.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [4]
RP FUNCTION, AND MUTAGENESIS OF PRO-74 AND GLY-330.
RX PubMed=22740615; DOI=10.1104/pp.112.197152;
RA Yang Y., Zhang Y., Ding P., Johnson K., Li X., Zhang Y.;
RT "The ankyrin-repeat transmembrane protein BDA1 functions downstream of the
RT receptor-like protein SNC2 to regulate plant immunity.";
RL Plant Physiol. 159:1857-1865(2012).
CC -!- FUNCTION: Involved in plant defense. Required for basal resistance
CC against Pseudomonas syringae pv. tomato DC3000. Required for resistance
CC against nonpathogenic bacteria. May be involved in signaling components
CC that function downstream of SNC2 and upstream of NPR1 and WRKY70 to
CC regulate defense responses. {ECO:0000269|PubMed:22740615}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB09340.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB016879; BAB09340.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED96518.1; -; Genomic_DNA.
DR EMBL; AK117622; BAC42278.1; -; mRNA.
DR RefSeq; NP_200272.2; NM_124842.4.
DR AlphaFoldDB; Q8GYH5; -.
DR SMR; Q8GYH5; -.
DR STRING; 3702.AT5G54610.1; -.
DR PaxDb; Q8GYH5; -.
DR PRIDE; Q8GYH5; -.
DR ProteomicsDB; 240843; -.
DR EnsemblPlants; AT5G54610.1; AT5G54610.1; AT5G54610.
DR GeneID; 835550; -.
DR Gramene; AT5G54610.1; AT5G54610.1; AT5G54610.
DR KEGG; ath:AT5G54610; -.
DR Araport; AT5G54610; -.
DR TAIR; locus:2172089; AT5G54610.
DR eggNOG; KOG0504; Eukaryota.
DR HOGENOM; CLU_000134_47_1_1; -.
DR InParanoid; Q8GYH5; -.
DR OMA; HITIMND; -.
DR OrthoDB; 799237at2759; -.
DR PhylomeDB; Q8GYH5; -.
DR PRO; PR:Q8GYH5; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8GYH5; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045087; P:innate immune response; IMP:TAIR.
DR GO; GO:0009751; P:response to salicylic acid; IEP:TAIR.
DR Gene3D; 1.25.40.20; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 5.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 1.
PE 1: Evidence at protein level;
KW ANK repeat; Cell membrane; Membrane; Plant defense; Reference proteome;
KW Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..426
FT /note="Ankyrin repeat-containing protein BDA1"
FT /id="PRO_0000438695"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 329..349
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 355..375
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 380..400
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REPEAT 1..29
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 36..65
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 70..99
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 104..134
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT REPEAT 138..167
FT /note="ANK 5"
FT /evidence="ECO:0000255"
FT REPEAT 182..212
FT /note="ANK 6"
FT /evidence="ECO:0000255"
FT MUTAGEN 74
FT /note="P->L: In bad1-1; suppression of constitutive
FT activation of defense responses in snc2-1D mutant."
FT /evidence="ECO:0000269|PubMed:22740615"
FT MUTAGEN 330
FT /note="G->E: In bad1-17D; gain-of-function mutant. Dwarf
FT and lesion mimic phenotype. Constitutive activation of
FT defense responses."
FT /evidence="ECO:0000269|PubMed:22740615"
SQ SEQUENCE 426 AA; 48346 MW; 28FF83EEC61A74A5 CRC64;
MDSKLLLVTQ SGSVDDLYSL IQAAPDILQK VDVLPIIHTP LHEASSAGKL DLAMELMILK
PSFAKKLNEY GLSPLHLAVE NDQVELALEL VKVDPSLVRI RGRGGMTPLH LVAKKGDVDL
LTDFLLACPE SIKDVNVNGE TILHITIMND KYEQLKVLTG WMQKMRDSDD VFIDVLNRRD
RGGNTVLHLA AYENNDKVVK QLVKCLSLDR NIQNKSGMTA LDVLRARGSH MNKEIEEIIQ
MSGGKTGGSL SGIQEWYIFL REPVTFKEHC KTRIARYRSR ISDGSRNALL VIAALIISAT
FQTAAQLLDK EKLDKVKKNG MRFSEFQLWG CNTVAFSIAI LFSFILLPVG RAYEWWYFII
TVPLVFSYFL LMYMMHGLSF FFLIIYEGGL FLVYLLVLYV KWKRCTQMKV RKPKSDLISD
NFKNMV
