ABCA6_DICDI
ID ABCA6_DICDI Reviewed; 1631 AA.
AC Q8T6J1; Q54EM9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=ABC transporter A family member 6;
DE AltName: Full=ABC transporter ABCA.6;
GN Name=abcA6; ORFNames=DDB_G0291245;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AF465308; AAL85299.1; -; Genomic_DNA.
DR EMBL; AAFI02000177; EAL61606.1; -; Genomic_DNA.
DR RefSeq; XP_635211.1; XM_630119.1.
DR AlphaFoldDB; Q8T6J1; -.
DR SMR; Q8T6J1; -.
DR STRING; 44689.DDB0201627; -.
DR PaxDb; Q8T6J1; -.
DR EnsemblProtists; EAL61606; EAL61606; DDB_G0291245.
DR GeneID; 8628157; -.
DR KEGG; ddi:DDB_G0291245; -.
DR dictyBase; DDB_G0291245; abcA6.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_1_1; -.
DR InParanoid; Q8T6J1; -.
DR OMA; GTAYTWR; -.
DR PhylomeDB; Q8T6J1; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8963896; HDL assembly.
DR PRO; PR:Q8T6J1; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1631
FT /note="ABC transporter A family member 6"
FT /id="PRO_0000363838"
FT TRANSMEM 25..45
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 242..262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 317..337
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 372..392
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 416..436
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 866..886
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1047..1067
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1099..1119
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1127..1147
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1158..1178
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1198..1218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 1242..1262
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 491..724
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 1309..1544
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 527..534
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1347..1354
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1631 AA; 181971 MW; 54139209CFF6EA4D CRC64;
MEFGRQLKTL LKKNLLLKGK SKCSICCEIV FPIVIIGVLF AILALIKVTN SDYNSIDVTT
FSRRVGPENK LLYGSEGSLN NDQSGVIETM KEQVATARGL TVAEVQDFFM EINDRTLMES
FFKNYSMMVY GGVWFNSSTN GGGGGNNNDP IAAGGQFGYN IRLDSDDTAD TSETGKVDGG
DSSIYLNDNF ASIQVAMDQA IFGYFGLDMV LNISGRHYPD PYTELWQEWI TGRDAIIKSA
GSVFITAALM MFSFRLVTDV VIEKETKIVE AMRMMSLNSL AYFSSWIITS LITSLPVTLL
IVVIFKGSQL IYSTSWGIVI ITFVLYLITL LLLSFIFSIF FNNSKFCGLL SFVIVIAINI
CGIFVSKNEF SVSVKLLLSI FSPIAFSNSI YIMSVKDLTM ILNLNWDYIV TENQSILMLG
IDIIIYIILI WYFEKVIPGE YGTKEKFYFL FTKNYWFGKK RSIGEIDDIE STFDSEDVET
IPLKVLKNST ISIRNLRKEF ETGDGLRVAV NDLYLDMFED QIHALLGPNG CGKSTTIGML
TGLISPTSGS AFIRGYDITS QMSKIRPYIG CCLQTDIIWS QLTVLEHLVI YASLKGVEGR
NIQREAERMA TEVGLAEKMN APAGSLSGGQ KRKLCLGIAF IGRSKIIFLD EVTSGMDPVS
RRQVWDFLLK YKKGKTIILT THYLEEADYL GDRIAIISQG KLRCDGTSLF LKNRFGQGYL
LTCNKKLENA SNGFNTNQVS EFIKNFIPGA SILTDSGAEL SYRLPTESLS NFPQFFTEFD
LNLSKFSIQT YGISVTSLEE VFISLGQEDS KKLNNNANGN NEFNKQNEME SLKLAIATPS
DGINQIQQFK GLLIKRIQQS KKDARSFFLS IILPMALIIG SIILYKSMND QKQVLFYNNS
TQPLTMSLSI YTDSDNTINV PMQLLNNELE WSNLFNNSPY FNKFKYINES INFNDYLIDN
YKLSIGAINF TNQPISIDDN NNGQSTNCSY IAYYNSDYIH SFPIHVNLIN DALLRKFKNI
SISVTSMPFD HILTAFEISS SDINASAIIY FVFILMAGFS LMAGSFAGSI AQERTNRVKR
LLYVSGCKKH IYWLSNLVWD FFFAFIISIL SCSILAGVIK GAFKEQFGSF LLCLILLSCA
IIPLGYLMSY KFQTYGKAVG AITAILFVFG LVFTIASLNV RIQAVVNQNS TTQKVADIID
LIFSIISPIF ALNRIVFILS GFPGSTRLGT FKVDNYWSFD YLGTPLIVLA GHAVLWNVWI
LLLDYVPQIK GFFKNPKNLP APSPPQDEDY DVSQERRRLL NMRPSEEPIQ FKNLHKLFPG
SGKNPSKTAV YNSTLGIPRG QTFGLLGLNG GGKSTTLSML SGEIVPSSGE ISINGYDVIT
NREKALGNIS MVFQFDALIS LLSAREHLWL FSRIKGIKES QIENCVEAFI KMVDLTRIAN
SGCGGYSGGN KRKVSLSMAM LGNPSVCFLD EISCGCDAVV RRQLWDVISE LGKDKSIILT
SHSMSEVEAL CSRITIMKEG KYTCLNTIQG VKNRFGAGYS IDVKFKKEYL ETGIQTILQS
IPNCTVLDQH DVMASFEVPN PPGNPIKLSN IFSILSNLPI LDDYNVGQTS LESVFLKLTG
ANHDQRINLY D
