ID   BAER_ECOL6              Reviewed;         240 AA.
AC   P69229; P30846;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Transcriptional regulatory protein BaeR;
GN   Name=baeR; OrderedLocusNames=c2605;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Member of the two-component regulatory system BaeS/BaeR.
CC       Activates the mdtABCD operon (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- PTM: Phosphorylated by BaeS. {ECO:0000250}.
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DR   EMBL; AE014075; AAN81061.1; -; Genomic_DNA.
DR   RefSeq; WP_000137877.1; NC_004431.1.
DR   PDB; 4B09; X-ray; 3.30 A; A/B/C/D/E/F/G/H/I/J/K/L=1-240.
DR   PDBsum; 4B09; -.
DR   AlphaFoldDB; P69229; -.
DR   SMR; P69229; -.
DR   STRING; 199310.c2605; -.
DR   EnsemblBacteria; AAN81061; AAN81061; c2605.
DR   KEGG; ecc:c2605; -.
DR   eggNOG; COG0745; Bacteria.
DR   HOGENOM; CLU_000445_30_4_6; -.
DR   OMA; EFNILHF; -.
DR   BioCyc; ECOL199310:C2605-MON; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; DNA-binding; Phosphoprotein; Transcription;
KW   Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..240
FT                   /note="Transcriptional regulatory protein BaeR"
FT                   /id="PRO_0000081022"
FT   DOMAIN          12..125
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        131..234
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         61
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   STRAND          12..16
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   HELIX           20..32
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          36..40
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   HELIX           46..52
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          56..61
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   HELIX           68..79
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          84..87
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          104..108
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   HELIX           114..124
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          143..146
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   TURN            147..150
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          151..154
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   HELIX           163..174
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   HELIX           182..191
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   HELIX           201..215
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          217..219
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          222..225
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   TURN            226..228
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          229..232
FT                   /evidence="ECO:0007829|PDB:4B09"
FT   STRAND          238..240
FT                   /evidence="ECO:0007829|PDB:4B09"
SQ   SEQUENCE   240 AA;  27656 MW;  8E2F6C9EB911C9CC CRC64;
     MTELPIDENT PRILIVEDEP KLGQLLIDYL RAASYAPTLI SHGDQVLPYV RQTPPDLILL
     DLMLPGTDGL TLCREIRRFS DIPIVMVTAK IEEIDRLLGL EIGADDYICK PYSPREVVAR
     VKTILRRCKP QRELQQQDAE SPLIIDEGRF QASWRGKMLD LTPAEFRLLK TLSHEPGKVF
     SREQLLNHLY DDYRVVTDRT IDSHIKNLRR KLESLDAEQS FIRAVYGVGY RWEADACRIV