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ABCA6_MOUSE
ID   ABCA6_MOUSE             Reviewed;        1624 AA.
AC   Q8K441; A2A6R3; Q8BGH0; Q8BPT1;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=ATP-binding cassette sub-family A member 6 {ECO:0000305};
DE            EC=7.6.2.- {ECO:0000250|UniProtKB:Q8N139};
GN   Name=Abca6;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=BALB/cJ; TISSUE=Liver;
RX   PubMed=12532264; DOI=10.1007/s00335-002-2229-9;
RA   Annilo T., Chen Z.-Q., Shulenin S., Dean M.;
RT   "Evolutionary analysis of a cluster of ATP-binding cassette (ABC) genes.";
RL   Mamm. Genome 14:7-20(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=C57BL/6J; TISSUE=Aorta, Cerebellum, Eye, and Vein;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver, and Lung;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Probable transporter which may play a role in macrophage
CC       lipid transport and homeostasis. {ECO:0000250|UniProtKB:Q8N139}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q8N139}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q8N139}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8K441-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8K441-2; Sequence=VSP_020699, VSP_020700;
CC   -!- TISSUE SPECIFICITY: Widely expressed with higher expression in heart,
CC       lung, brain, spleen and testis. {ECO:0000269|PubMed:12532264}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis.
CC       {ECO:0000269|PubMed:12532264}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC       {ECO:0000305}.
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DR   EMBL; AF498361; AAM90907.1; -; mRNA.
DR   EMBL; AK040652; BAC30657.1; -; mRNA.
DR   EMBL; AK042934; BAC31409.1; -; mRNA.
DR   EMBL; AK053384; BAC35372.1; -; mRNA.
DR   EMBL; AL603792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC132417; AAI32418.1; -; mRNA.
DR   EMBL; BC132419; AAI32420.1; -; mRNA.
DR   CCDS; CCDS25590.1; -. [Q8K441-1]
DR   RefSeq; NP_001160028.1; NM_001166556.1. [Q8K441-2]
DR   RefSeq; NP_001160029.1; NM_001166557.1.
DR   RefSeq; NP_671751.2; NM_147218.2. [Q8K441-1]
DR   RefSeq; XP_006534476.1; XM_006534413.1. [Q8K441-1]
DR   RefSeq; XP_006534477.1; XM_006534414.2. [Q8K441-1]
DR   AlphaFoldDB; Q8K441; -.
DR   SMR; Q8K441; -.
DR   BioGRID; 218010; 13.
DR   STRING; 10090.ENSMUSP00000035458; -.
DR   GlyGen; Q8K441; 3 sites.
DR   iPTMnet; Q8K441; -.
DR   PhosphoSitePlus; Q8K441; -.
DR   SwissPalm; Q8K441; -.
DR   CPTAC; non-CPTAC-3441; -.
DR   jPOST; Q8K441; -.
DR   MaxQB; Q8K441; -.
DR   PaxDb; Q8K441; -.
DR   PeptideAtlas; Q8K441; -.
DR   PRIDE; Q8K441; -.
DR   ProteomicsDB; 285744; -. [Q8K441-1]
DR   ProteomicsDB; 285745; -. [Q8K441-2]
DR   Antibodypedia; 31832; 166 antibodies from 27 providers.
DR   DNASU; 76184; -.
DR   Ensembl; ENSMUST00000044003; ENSMUSP00000035458; ENSMUSG00000044749. [Q8K441-1]
DR   GeneID; 76184; -.
DR   KEGG; mmu:76184; -.
DR   UCSC; uc007mdj.3; mouse. [Q8K441-1]
DR   UCSC; uc007mdk.2; mouse. [Q8K441-2]
DR   CTD; 23460; -.
DR   MGI; MGI:1923434; Abca6.
DR   VEuPathDB; HostDB:ENSMUSG00000044749; -.
DR   eggNOG; KOG0059; Eukaryota.
DR   GeneTree; ENSGT00940000162244; -.
DR   HOGENOM; CLU_000604_19_1_1; -.
DR   InParanoid; Q8K441; -.
DR   OMA; ERRADHV; -.
DR   OrthoDB; 131191at2759; -.
DR   PhylomeDB; Q8K441; -.
DR   TreeFam; TF105192; -.
DR   Reactome; R-MMU-1369062; ABC transporters in lipid homeostasis.
DR   BioGRID-ORCS; 76184; 4 hits in 71 CRISPR screens.
DR   ChiTaRS; Abca6; mouse.
DR   PRO; PR:Q8K441; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8K441; protein.
DR   Bgee; ENSMUSG00000044749; Expressed in lumbar dorsal root ganglion and 49 other tissues.
DR   Genevisible; Q8K441; MM.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR030368; ABCA6.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; PTHR19229; 1.
DR   PANTHER; PTHR19229:SF13; PTHR19229:SF13; 1.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   1: Evidence at protein level;
KW   Alternative splicing; ATP-binding; Glycoprotein; Golgi apparatus; Membrane;
KW   Nucleotide-binding; Reference proteome; Repeat; Translocase; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..1624
FT                   /note="ATP-binding cassette sub-family A member 6"
FT                   /id="PRO_0000250673"
FT   TRANSMEM        31..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        222..242
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        267..287
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        395..415
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        854..874
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        971..991
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1005..1025
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1058..1078
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1094..1114
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1130..1150
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1154..1174
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1194..1214
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          478..713
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          1282..1520
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         514..521
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         1320..1327
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   CARBOHYD        84
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        576
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         375..388
FT                   /note="IFQDYNLNGVVFPD -> NTEVITDASNGINP (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_020699"
FT   VAR_SEQ         389..1624
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_020700"
FT   CONFLICT        331
FT                   /note="I -> V (in Ref. 3; BAC35372)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        1020
FT                   /note="I -> T (in Ref. 1; AAM90907)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1624 AA;  183283 MW;  90C077C465B5F79C CRC64;
     MKELSVHVRQ QTRALLHKIL LKKWRRKRES LLEWSIPIII GLHMGLFSYL ARNIQVLEVP
     PQDLGSLNEF NGSSLVVVYT PISNITQQIM NKTTFAPTMK GTRIIGVPSI EDLDEVLLHN
     IPDALGVIFN DSFSYQLKVL RMYGNPFLKE DLLAHCWDTH SQAFCSLSKY WERGFVALQT
     AINAGIIEVT TNHSVMEELM SIDGINMKTL PFIPRDLSDY EIFILFCLLY FSSFIYFASS
     NVTKERKQCK EVMKVMGLQD SAFWLSWGLI YVGFIFIISI FIAIIITSTQ IIMMTGFLVI
     FTLFFLYGLS LIAVTFLMAV LLQKAVLTNL IVLFFTLFWG CVGFTVLHKE LPPSLEWVLS
     IFSPFAFTSG MAKVIFQDYN LNGVVFPDPS GESYVMIAVF FILAFDSLLY LVLALYFDKI
     LLYGAEHRSA PLFFLNPTSC FRKTANRNKV IERDLDPELP SDEYFEPVDP EYQGKEAIRI
     RNIKKEYKGK SGKVKALKGL FLDIYESQIT AILGHSGAGK SSLLNILSGL YVPTAGSVTV
     YNKNLSDMQD LKEIRKAIGV CPQHNVQFDA LTVKENLTLF AKIKGILPQD VEQEVQQILS
     ELDMQNIRDD LAEHLSEGQK RKLTFGIATV GDPQILLLDE PTVGLDPFSR QRIWGFLKER
     RADHVILFST QFMDEADILA DRKVLIANGA LKCTGSSVFL KRKWGLGYHL SLFMDETCDS
     ERLTSFINHH IPYAKLKAKT KEKLVYILPL ERTSEFPEFF SDLDKYSGQG LMSYEVSMST
     LNDVFLNLEG EPSTKQDFEK RETATDSESL NDMEVAYPSL SQVQETVSTM SLWRMQVCAI
     ARLRILKLKR ERKAFLIILL LLGIALLPLV IEYVANALLE VKNNWEFKTD LYFLSPGQLP
     QGLRTSLLVI NNTESNIEDF LQSLKHQNIV LEVDDFENRN ATNSLSYNGA IIVSGRQKDY
     RFSAVCNTKR LHCFPILMNV ISNGILHMLN HTQYIRIKED IFSPFIVLVW TGIQETCLFI
     LCVICSLSPH IAMSSVSDYK KKADSQLWIS GLYPSAYWCG QAVVDISLFS GMLLTSYFTS
     YTSKLLNIDM TSEIVFSVIV LALGCAASLV FLTYVISFVF GKRKKNSTLW SICFLLVIAI
     TFEKVANGPF NEALVISATM LVPSFALNGL LVVLEMRAYQ YYIEFEEIKH GLSAVDLLLC
     LIPYIHTLLF IFVLRCLELK YGKNVVRRDP IFRIAPQSLK AQPNPEEPID EDENVQAERL
     RTSDALSTPN LDEKPVIIAS CLHKEYAGQK KHCCSRRTRN MAVRNVSFCV NKGEILGLLG
     PDGAGKSSSI RMIAGITKPT AGQVELKRLS SAVGHQGDSR AEFGYCPQEN GLWPNLTVKE
     HLELYAAVKG LRKEDAVVAI SRLVNALKLH DQLNVQVQNL VAGATRKLCF VLSILGNSPV
     LILDEPSTGL DVSGKHQVWQ AIQAVVKDNE KGVLLSTHDL AEAEALCDRA AIMVSGRLRC
     IGPIQHLKRK FGQDYVLELR VKDVSQEPLV HREILKLFPQ AARQDRCFSL LTYKLPVTDV
     HPLSQAFHKL EAVKHGFDLE DYSLSQCTLD RVILELSKEQ ELGTVYEEAD MTLGRKLLPP
     SDEL
 
 
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