BAFB_XENLA
ID BAFB_XENLA Reviewed; 90 AA.
AC Q66KV4;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 64.
DE RecName: Full=Barrier-to-autointegration factor B;
GN Name=banf1-b; Synonyms=baf-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP SUBCELLULAR LOCATION, INTERACTION WITH NEMP1A AND NEMP1B, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=19167377; DOI=10.1016/j.ydbio.2008.12.038;
RA Mamada H., Takahashi N., Taira M.;
RT "Involvement of an inner nuclear membrane protein, Nemp1, in Xenopus neural
RT development through an interaction with the chromatin protein BAF.";
RL Dev. Biol. 327:497-507(2009).
CC -!- FUNCTION: Plays fundamental roles in nuclear assembly, chromatin
CC organization, gene expression and gonad development. May potently
CC compress chromatin structure and be involved in membrane recruitment
CC and chromatin decondensation during nuclear assembly. Contains 2 non-
CC specific dsDNA-binding sites which may promote DNA cross-bridging (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Binds non-specifically to double-stranded DNA, and
CC is found as hexamer or dodecamer upon DNA binding. Binds to LEM domain-
CC containing nuclear proteins (By similarity). Interacts with nemp1a and
CC nemp1b. {ECO:0000250, ECO:0000269|PubMed:19167377}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19167377}. Nucleus
CC envelope {ECO:0000269|PubMed:19167377}. Chromosome {ECO:0000250}.
CC Note=Colocalizes with nemp1a and nemp1b at the nuclear envelope.
CC {ECO:0000269|PubMed:19167377}.
CC -!- DEVELOPMENTAL STAGE: At the early gastrula stage, expressed mainly in
CC the entire animal hemisphere. During neurulation, its expression
CC becomes restricted to the anterior neuroectoderm. At the tailbud stage,
CC expressed in various anterior regions including the anterior central
CC nervous system (CNS), otic vesicles, and branchial arches.
CC {ECO:0000269|PubMed:19167377}.
CC -!- PTM: Phosphorylated during S and M phases. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the BAF family. {ECO:0000305}.
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DR EMBL; BC078546; AAH78546.1; -; mRNA.
DR RefSeq; NP_001087314.1; NM_001093845.1.
DR AlphaFoldDB; Q66KV4; -.
DR SMR; Q66KV4; -.
DR BioGRID; 103997; 1.
DR IntAct; Q66KV4; 2.
DR DNASU; 447137; -.
DR GeneID; 447137; -.
DR KEGG; xla:447137; -.
DR CTD; 447137; -.
DR Xenbase; XB-GENE-6254337; banf1.S.
DR OMA; SKQQGDC; -.
DR OrthoDB; 1617480at2759; -.
DR Proteomes; UP000186698; Chromosome 4S.
DR Bgee; 447137; Expressed in oocyte and 19 other tissues.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005635; C:nuclear envelope; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.40; -; 1.
DR InterPro; IPR004122; BAF_prot.
DR InterPro; IPR036617; BAF_sf.
DR Pfam; PF02961; BAF; 1.
DR SMART; SM01023; BAF; 1.
DR SUPFAM; SSF47798; SSF47798; 1.
PE 1: Evidence at protein level;
KW Chromosome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..90
FT /note="Barrier-to-autointegration factor B"
FT /id="PRO_0000223615"
SQ SEQUENCE 90 AA; 10199 MW; 7F630D18484A0710 CRC64;
MSSTSQKHRD FVAEPMGEKS VQCLAGIGDT LGRRLEEKGF DKAYVVLGQF LVLKKDEELF
KEWLKDACSA NAKQSRDCYG CLKEWCDAFL
