ABCA7_DICDI
ID ABCA7_DICDI Reviewed; 839 AA.
AC Q8T6J0; Q55BB9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=ABC transporter A family member 7;
DE AltName: Full=ABC transporter ABCA.7;
GN Name=abcA7; ORFNames=DDB_G0271140;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AF465309; AAL85300.1; -; Genomic_DNA.
DR EMBL; AAFI02000006; EAL71700.1; -; Genomic_DNA.
DR RefSeq; XP_645693.1; XM_640601.1.
DR AlphaFoldDB; Q8T6J0; -.
DR SMR; Q8T6J0; -.
DR PaxDb; Q8T6J0; -.
DR EnsemblProtists; EAL71700; EAL71700; DDB_G0271140.
DR GeneID; 8617886; -.
DR KEGG; ddi:DDB_G0271140; -.
DR dictyBase; DDB_G0271140; abcA7.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q8T6J0; -.
DR OMA; TNANGKC; -.
DR PhylomeDB; Q8T6J0; -.
DR PRO; PR:Q8T6J0; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; IEP:dictyBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..839
FT /note="ABC transporter A family member 7"
FT /id="PRO_0000363839"
FT TRANSMEM 30..50
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 321..341
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 378..398
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 525..756
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 559..566
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 839 AA; 95309 MW; 8CF4B6F2AD1EBF23 CRC64;
MKYNANTSNQ FRAMFFKNAT FLKRQKCSLG VQIAIPMALV IVLVILKLWI ESQIENNSGP
VGDSSGDDIM GSYISYKFDY MQGWFYTINP NNITNIGYKD GYGNGTGLLG GINQYEIYWN
GSDLWVPYTV AVESGQKMND MVLAQKQQLG QSSMGPLTFP IAGIQFNEFN PQNNLIDLTI
TCEQQIRYAY NNFENNLIYV LSQIQTSFIN YLLNGNGVVV KTQISTLPYI YKSQQFDIAS
LLGGSFFPFA LSFVLPLFMY SIVYEKQEKL RDLSLMMGLK MRNYWIMTFI FNFLTYVVIV
SVISLICSAA KVSLFVKGSP FALFLLLFLW GLSMVSFAFF LSTFFKRTRA ASIFGYFFVM
VMVNLNSTLS LFNTSVPVFY YWVPILAFSR GISTLCGLCG NGLCPPLSQY TWDFELSRIL
FWLFIDTIVY LTLAVYLDKV LPREFGVPSH PLFFIKDLKE LFSKKGKYRK LRDGDGINEK
TKLINEYTID GINNDDDDDG LMDEDVKKER DMIVKGEYNP EEMTLIVQGL RKQFPGRPKP
ALSNLYLSVK KGEVLGYLGP NGAGKTTSIS ILTGLYTPTS GTAHIAGLDI RYDMDKIHQV
IGVVMQFDVL WEDLTCEETI LYYTRLKGTP KSIEFESTHN ILKEVNLLDV KDRFVKELSG
GMKRRLSFAI AMTGESSIIF LDEPTTGLSI ETRKDLWGTI NELKKNRSII LTTHSMQEAD
ILSDRIAIVS QGKLQCIGTQ THLKQKFGDG YSVRIDIQED YQNTHNPTDL IKSFSPSATL
SETFNGSYVY RLPKDSIISD LYEYLVLNKE QYHLQEWSLS QTSLEDVFLK ISANDDTVN
