BAG1_ARATH
ID BAG1_ARATH Reviewed; 342 AA.
AC Q0WUQ1; Q9FJ86;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=BAG family molecular chaperone regulator 1;
DE AltName: Full=Bcl-2-associated athanogene 1;
GN Name=BAG1; OrderedLocusNames=At5g52060; ORFNames=MSG15.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 17-342.
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX DOI=10.1016/S0168-9452(03)00121-3;
RA Juqiang Y., Cixin H., Hong Z.;
RT "The BAG-family proteins in Arabidopsis thaliana.";
RL Plant Sci. 165:1-7(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=16636050; DOI=10.1074/jbc.m511794200;
RA Doukhanina E.V., Chen S., van der Zalm E., Godzik A., Reed J.,
RA Dickman M.B.;
RT "Identification and functional characterization of the BAG protein family
RT in Arabidopsis thaliana.";
RL J. Biol. Chem. 281:18793-18801(2006).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-298, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19376835; DOI=10.1104/pp.109.138677;
RA Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,
RA Grossmann J., Gruissem W., Baginsky S.;
RT "Large-scale Arabidopsis phosphoproteome profiling reveals novel
RT chloroplast kinase substrates and phosphorylation networks.";
RL Plant Physiol. 150:889-903(2009).
CC -!- FUNCTION: Co-chaperone that regulates diverse cellular pathways, such
CC as programmed cell death and stress responses. {ECO:0000250}.
CC -!- SUBUNIT: Binds to the ATPase domain of HSP70/HSC70 chaperones.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB11054.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB015478; BAB11054.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002688; AED96167.1; -; Genomic_DNA.
DR EMBL; AK227095; BAE99147.1; -; mRNA.
DR EMBL; BT030041; ABN04779.1; -; mRNA.
DR RefSeq; NP_200019.2; NM_124585.4.
DR PDB; 4HWC; X-ray; 1.80 A; A/B/C/D/E/F=157-241.
DR PDB; 4HWI; X-ray; 2.27 A; B=66-242.
DR PDBsum; 4HWC; -.
DR PDBsum; 4HWI; -.
DR AlphaFoldDB; Q0WUQ1; -.
DR SMR; Q0WUQ1; -.
DR BioGRID; 20526; 1.
DR STRING; 3702.AT5G52060.1; -.
DR iPTMnet; Q0WUQ1; -.
DR PaxDb; Q0WUQ1; -.
DR PRIDE; Q0WUQ1; -.
DR ProteomicsDB; 240809; -.
DR EnsemblPlants; AT5G52060.1; AT5G52060.1; AT5G52060.
DR GeneID; 835281; -.
DR Gramene; AT5G52060.1; AT5G52060.1; AT5G52060.
DR KEGG; ath:AT5G52060; -.
DR Araport; AT5G52060; -.
DR TAIR; locus:2173108; AT5G52060.
DR eggNOG; KOG4361; Eukaryota.
DR HOGENOM; CLU_043370_1_0_1; -.
DR OMA; AMPNTNG; -.
DR OrthoDB; 1266506at2759; -.
DR PhylomeDB; Q0WUQ1; -.
DR PRO; PR:Q0WUQ1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q0WUQ1; baseline and differential.
DR Genevisible; Q0WUQ1; AT.
DR GO; GO:0005829; C:cytosol; IDA:TAIR.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR GO; GO:0071629; P:cytoplasm protein quality control by the ubiquitin-proteasome system; IMP:TAIR.
DR GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR Gene3D; 1.20.58.120; -; 1.
DR IDEAL; IID50190; -.
DR InterPro; IPR039773; BAG_chaperone_regulator.
DR InterPro; IPR036533; BAG_dom_sf.
DR InterPro; IPR003103; BAG_domain.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12329; PTHR12329; 1.
DR Pfam; PF02179; BAG; 1.
DR SMART; SM00264; BAG; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR SUPFAM; SSF63491; SSF63491; 1.
DR PROSITE; PS51035; BAG; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chaperone; Phosphoprotein; Reference proteome.
FT CHAIN 1..342
FT /note="BAG family molecular chaperone regulator 1"
FT /id="PRO_0000415521"
FT DOMAIN 65..141
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 160..238
FT /note="BAG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00369"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 298
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19376835"
FT STRAND 67..73
FT /evidence="ECO:0007829|PDB:4HWI"
FT STRAND 76..82
FT /evidence="ECO:0007829|PDB:4HWI"
FT HELIX 88..99
FT /evidence="ECO:0007829|PDB:4HWI"
FT HELIX 103..105
FT /evidence="ECO:0007829|PDB:4HWI"
FT STRAND 106..110
FT /evidence="ECO:0007829|PDB:4HWI"
FT TURN 121..125
FT /evidence="ECO:0007829|PDB:4HWI"
FT STRAND 130..136
FT /evidence="ECO:0007829|PDB:4HWI"
FT HELIX 157..183
FT /evidence="ECO:0007829|PDB:4HWC"
FT HELIX 190..207
FT /evidence="ECO:0007829|PDB:4HWC"
FT HELIX 214..240
FT /evidence="ECO:0007829|PDB:4HWC"
SQ SEQUENCE 342 AA; 38191 MW; E1F103F7230D55E5 CRC64;
MMKMMRNKPT NLPTAGMTNG GRGSGGGGGG GGRESGGRDL EIRPGGMLVQ KRNPDLDPVG
PPPPPMIRVR IKYGAVYHEI NISPQASFGE LKKMLTGPTG IHHQDQKLMY KDKERDSKAF
LDVSGVKDKS KMVLIEDPLS QEKRFLEMRK IAKTEKASKA ISDISLEVDR LGGRVSAFEM
VTKKGGKIAE KDLVTVIELL MNELIKLDAI VAEGDVKLQR KMQVKRVQNY VETLDALKVK
NSMANGQQKQ SSTAQRLAPI QEHNNEERQE QKPIQSLMDM PIQYKEKKQE IEEEPRNSGE
GPFVLDSSAK WETFDHHPVT PLSSTTAKNN AIPPRFNWEF FD
