RS31_XENLA
ID RS31_XENLA Reviewed; 246 AA.
AC P02350; Q642U2;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=40S ribosomal protein S3-A;
DE EC=4.2.99.18 {ECO:0000250|UniProtKB:P23396};
DE AltName: Full=S1A;
GN Name=rps3-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2030971; DOI=10.1093/nar/19.8.1943;
RA di Cristina M., Menard R., Pierandrei-Amaldi P.;
RT "Xenopus laevis ribosomal protein S1a cDNA sequence.";
RL Nucleic Acids Res. 19:1943-1943(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE.
RX PubMed=7049839; DOI=10.1016/0378-1119(82)90147-0;
RA Amaldi F., Beccari E., Bozzoni I., Luo Z.-X., Pierandrei-Amaldi P.;
RT "Nucleotide sequences of cloned cDNA fragments specific for six Xenopus
RT laevis ribosomal proteins.";
RL Gene 17:311-316(1982).
CC -!- FUNCTION: Involved in translation as a component of the 40S small
CC ribosomal subunit. Has endonuclease activity and plays a role in repair
CC of damaged DNA. Also involved in other processes including regulation
CC of transcription, translation of its cognate mRNA, spindle formation
CC and chromosome movement during mitosis, and apoptosis.
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-
CC deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-
CC dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-
CC 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-
CC COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695,
CC ChEBI:CHEBI:167181; EC=4.2.99.18;
CC Evidence={ECO:0000250|UniProtKB:P23396};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23396}. Nucleus
CC {ECO:0000250|UniProtKB:P23396}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P23396}. Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P23396}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P23396}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS3 family.
CC {ECO:0000305}.
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DR EMBL; X57322; CAA40592.1; -; mRNA.
DR EMBL; BC042230; AAH42230.1; -; mRNA.
DR EMBL; V01441; CAA24702.1; ALT_SEQ; mRNA.
DR PIR; S15665; R3XL3A.
DR PIR; T01065; T01065.
DR RefSeq; NP_001094409.1; NM_001100939.1.
DR AlphaFoldDB; P02350; -.
DR BMRB; P02350; -.
DR SMR; P02350; -.
DR BioGRID; 103004; 2.
DR IntAct; P02350; 1.
DR DNASU; 444841; -.
DR GeneID; 444841; -.
DR KEGG; xla:444841; -.
DR CTD; 444841; -.
DR Xenbase; XB-GENE-978304; rps3.L.
DR OMA; RAGWAQW; -.
DR OrthoDB; 1135751at2759; -.
DR Proteomes; UP000186698; Chromosome 2L.
DR Bgee; 444841; Expressed in internal ear and 19 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.1140.32; -; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR004044; KH_dom_type_2.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR001351; Ribosomal_S3_C.
DR InterPro; IPR036419; Ribosomal_S3_C_sf.
DR InterPro; IPR018280; Ribosomal_S3_CS.
DR InterPro; IPR005703; Ribosomal_S3_euk/arc.
DR Pfam; PF07650; KH_2; 1.
DR Pfam; PF00189; Ribosomal_S3_C; 1.
DR SUPFAM; SSF54814; SSF54814; 1.
DR SUPFAM; SSF54821; SSF54821; 1.
DR TIGRFAMs; TIGR01008; uS3_euk_arch; 1.
DR PROSITE; PS50823; KH_TYPE_2; 1.
DR PROSITE; PS00548; RIBOSOMAL_S3; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; DNA damage;
KW DNA repair; DNA-binding; Lyase; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Mitosis; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; Transcription;
KW Transcription regulation; Translation regulation.
FT CHAIN 1..246
FT /note="40S ribosomal protein S3-A"
FT /id="PRO_0000130325"
FT DOMAIN 21..92
FT /note="KH type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00118"
FT REGION 215..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 27002 MW; 62F76F92E6D2042A CRC64;
MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG
EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY
GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG
VLGIKVKIML PWDPSGKIGP KKPLPDHVSI VEPKDEIVPT TPISEQKAAK PDQPQPPAMP
QPVATA
