BAG2_ARATH
ID BAG2_ARATH Reviewed; 285 AA.
AC Q0WPX7; F4K550; Q8LEP8; Q9FIS8;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 78.
DE RecName: Full=BAG family molecular chaperone regulator 2;
DE AltName: Full=Bcl-2-associated athanogene 2;
GN Name=BAG2; OrderedLocusNames=At5g62100; ORFNames=MTG10.13;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX DOI=10.1016/S0168-9452(03)00121-3;
RA Juqiang Y., Cixin H., Hong Z.;
RT "The BAG-family proteins in Arabidopsis thaliana.";
RL Plant Sci. 165:1-7(2003).
RN [6]
RP GENE FAMILY.
RX PubMed=16636050; DOI=10.1074/jbc.m511794200;
RA Doukhanina E.V., Chen S., van der Zalm E., Godzik A., Reed J.,
RA Dickman M.B.;
RT "Identification and functional characterization of the BAG protein family
RT in Arabidopsis thaliana.";
RL J. Biol. Chem. 281:18793-18801(2006).
CC -!- FUNCTION: Co-chaperone that regulates diverse cellular pathways, such
CC as programmed cell death and stress responses. {ECO:0000250}.
CC -!- SUBUNIT: Binds to the ATPase domain of HSP70/HSC70 chaperones.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q0WPX7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q0WPX7-2; Sequence=VSP_042273;
CC -!- MISCELLANEOUS: [Isoform 2]: May be due to a competing acceptor splice
CC site. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM62536.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB10172.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB016880; BAB10172.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002688; AED97562.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97563.1; -; Genomic_DNA.
DR EMBL; AK228933; BAF00822.1; -; mRNA.
DR EMBL; AY085305; AAM62536.1; ALT_INIT; mRNA.
DR RefSeq; NP_568950.2; NM_125603.3. [Q0WPX7-1]
DR RefSeq; NP_851246.1; NM_180915.1. [Q0WPX7-2]
DR PDB; 4HWD; X-ray; 2.31 A; A/B/D=129-214.
DR PDBsum; 4HWD; -.
DR AlphaFoldDB; Q0WPX7; -.
DR SMR; Q0WPX7; -.
DR PaxDb; Q0WPX7; -.
DR PRIDE; Q0WPX7; -.
DR ProteomicsDB; 240810; -. [Q0WPX7-1]
DR EnsemblPlants; AT5G62100.1; AT5G62100.1; AT5G62100. [Q0WPX7-2]
DR EnsemblPlants; AT5G62100.2; AT5G62100.2; AT5G62100. [Q0WPX7-1]
DR GeneID; 836330; -.
DR Gramene; AT5G62100.1; AT5G62100.1; AT5G62100. [Q0WPX7-2]
DR Gramene; AT5G62100.2; AT5G62100.2; AT5G62100. [Q0WPX7-1]
DR KEGG; ath:AT5G62100; -.
DR Araport; AT5G62100; -.
DR TAIR; locus:2174038; AT5G62100.
DR eggNOG; KOG4361; Eukaryota.
DR InParanoid; Q0WPX7; -.
DR OMA; PQHKERD; -.
DR OrthoDB; 1266506at2759; -.
DR PhylomeDB; Q0WPX7; -.
DR PRO; PR:Q0WPX7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q0WPX7; baseline and differential.
DR Genevisible; Q0WPX7; AT.
DR GO; GO:0000774; F:adenyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0051087; F:chaperone binding; IBA:GO_Central.
DR GO; GO:0050821; P:protein stabilization; IBA:GO_Central.
DR Gene3D; 1.20.58.120; -; 1.
DR InterPro; IPR039773; BAG_chaperone_regulator.
DR InterPro; IPR036533; BAG_dom_sf.
DR InterPro; IPR003103; BAG_domain.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12329; PTHR12329; 1.
DR Pfam; PF02179; BAG; 1.
DR SMART; SM00264; BAG; 1.
DR SUPFAM; SSF54236; SSF54236; 1.
DR SUPFAM; SSF63491; SSF63491; 1.
DR PROSITE; PS51035; BAG; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Chaperone; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..285
FT /note="BAG family molecular chaperone regulator 2"
FT /id="PRO_0000415522"
FT DOMAIN 37..113
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT DOMAIN 132..210
FT /note="BAG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00369"
FT MOD_RES 244
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0WUQ1"
FT VAR_SEQ 195
FT /note="Q -> QNLMIRFTNCWK (in isoform 2)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_042273"
FT HELIX 129..155
FT /evidence="ECO:0007829|PDB:4HWD"
FT HELIX 162..181
FT /evidence="ECO:0007829|PDB:4HWD"
FT HELIX 187..213
FT /evidence="ECO:0007829|PDB:4HWD"
SQ SEQUENCE 285 AA; 32263 MW; 11B860BABB9D3472 CRC64;
MMKMSIGTTT SGDGEMELRP GGMVVQKRTD HSSSVPRGIR VRVKYGSVHH EISINSQSTF
GELKKILSGA TGVHHQDMQI IYKDKERDSK MFLDLSGVKD RSKLILIEDP ISQEKRLLEL
RKIATKEKSS KAISDISFQV ERLAGQLSAF DTVIGKGGKV EEKNLENLME MLMNQLVKLD
AISGDGDVKL KKKMQEERLH KYVEALDLLK IKNSRQPQTK PKPQYKEREM LTFYEEASRK
PTASSSSPPV IITTRWETFD SSSASTATLQ PVRPVHPKFK WELFN
