RS32_XENLA
ID RS32_XENLA Reviewed; 246 AA.
AC P47835;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=40S ribosomal protein S3-B;
DE EC=4.2.99.18 {ECO:0000250|UniProtKB:P23396};
DE AltName: Full=S1B;
GN Name=rps3-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC TISSUE=Liver;
RX PubMed=7890156; DOI=10.1016/0378-1119(94)00834-f;
RA Pellizzoni L., Crosio C., Pierandrei-Amaldi P.;
RT "Sequence of the cDNA and gene coding for ribosomal protein S1 of Xenopus
RT laevis.";
RL Gene 154:145-151(1995).
CC -!- FUNCTION: Involved in translation as a component of the 40S small
CC ribosomal subunit. Has endonuclease activity and plays a role in repair
CC of damaged DNA. Also involved in other processes including regulation
CC of transcription, translation of its cognate mRNA, spindle formation
CC and chromosome movement during mitosis, and apoptosis.
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-
CC deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-
CC dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-
CC 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-
CC COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695,
CC ChEBI:CHEBI:167181; EC=4.2.99.18;
CC Evidence={ECO:0000250|UniProtKB:P23396};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23396}. Nucleus
CC {ECO:0000250|UniProtKB:P23396}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P23396}. Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P23396}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P23396}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS3 family.
CC {ECO:0000305}.
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DR EMBL; Z34530; CAA84291.1; -; Genomic_DNA.
DR EMBL; Z34529; CAA84290.1; -; mRNA.
DR PIR; I51636; I51635.
DR RefSeq; NP_001085315.1; NM_001091846.2.
DR AlphaFoldDB; P47835; -.
DR BMRB; P47835; -.
DR SMR; P47835; -.
DR BioGRID; 101904; 1.
DR DNASU; 443740; -.
DR GeneID; 443740; -.
DR KEGG; xla:443740; -.
DR CTD; 443740; -.
DR Xenbase; XB-GENE-6251888; rps3.S.
DR OrthoDB; 1135751at2759; -.
DR Proteomes; UP000186698; Chromosome 2S.
DR Bgee; 443740; Expressed in internal ear and 19 other tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.1140.32; -; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR004044; KH_dom_type_2.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR001351; Ribosomal_S3_C.
DR InterPro; IPR036419; Ribosomal_S3_C_sf.
DR InterPro; IPR018280; Ribosomal_S3_CS.
DR InterPro; IPR005703; Ribosomal_S3_euk/arc.
DR Pfam; PF07650; KH_2; 1.
DR Pfam; PF00189; Ribosomal_S3_C; 1.
DR SUPFAM; SSF54814; SSF54814; 1.
DR SUPFAM; SSF54821; SSF54821; 1.
DR TIGRFAMs; TIGR01008; uS3_euk_arch; 1.
DR PROSITE; PS50823; KH_TYPE_2; 1.
DR PROSITE; PS00548; RIBOSOMAL_S3; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; DNA damage;
KW DNA repair; DNA-binding; Lyase; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Mitosis; Nucleus; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; Transcription;
KW Transcription regulation; Translation regulation.
FT CHAIN 1..246
FT /note="40S ribosomal protein S3-B"
FT /id="PRO_0000130326"
FT DOMAIN 21..92
FT /note="KH type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00118"
FT REGION 212..246
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 246 AA; 26978 MW; 2211866095A311E9 CRC64;
MAAQMSKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTQTEIII LATRTQNVLG
EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY
GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG
VLGIKVKIML PWDPSGKIGP KKPLPDHVSI VEPKDEIVPT TPISEQKGAK PDQPQPPVMP
QPVATA
