BAG5_ARATH
ID BAG5_ARATH Reviewed; 215 AA.
AC O65373;
DT 22-FEB-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=BAG family molecular chaperone regulator 5, mitochondrial;
DE AltName: Full=Bcl-2-associated athanogene 5;
DE Flags: Precursor;
GN Name=BAG5; OrderedLocusNames=At1g12060; ORFNames=F12F1.7;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-192.
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX DOI=10.1016/S0168-9452(03)00121-3;
RA Juqiang Y., Cixin H., Hong Z.;
RT "The BAG-family proteins in Arabidopsis thaliana.";
RL Plant Sci. 165:1-7(2003).
RN [5]
RP INTERACTION WITH HSP70-1.
RX PubMed=16003391; DOI=10.1038/sj.cdd.4401712;
RA Kang C.H., Jung W.Y., Kang Y.H., Kim J.Y., Kim D.G., Jeong J.C., Baek D.W.,
RA Jin J.B., Lee J.Y., Kim M.O., Chung W.S., Mengiste T., Koiwa H., Kwak S.S.,
RA Bahk J.D., Lee S.Y., Nam J.S., Yun D.J., Cho M.J.;
RT "AtBAG6, a novel calmodulin-binding protein, induces programmed cell death
RT in yeast and plants.";
RL Cell Death Differ. 13:84-95(2006).
RN [6]
RP GENE FAMILY, AND INDUCTION.
RX PubMed=16636050; DOI=10.1074/jbc.m511794200;
RA Doukhanina E.V., Chen S., van der Zalm E., Godzik A., Reed J.,
RA Dickman M.B.;
RT "Identification and functional characterization of the BAG protein family
RT in Arabidopsis thaliana.";
RL J. Biol. Chem. 281:18793-18801(2006).
CC -!- FUNCTION: Co-chaperone that regulates diverse cellular pathways, such
CC as programmed cell death and stress responses. {ECO:0000250}.
CC -!- SUBUNIT: Binds to the ATPase domain of HSP70/HSC70 chaperones (By
CC similarity). Interacts with HSP70-1. {ECO:0000250,
CC ECO:0000269|PubMed:16003391}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC -!- INDUCTION: By calcium. {ECO:0000269|PubMed:16636050}.
CC -!- DOMAIN: IQ domain mediates interaction with calmodulin. {ECO:0000250}.
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DR EMBL; AC002131; AAC17606.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28831.1; -; Genomic_DNA.
DR EMBL; BX821823; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; G86255; G86255.
DR RefSeq; NP_172670.2; NM_101078.3.
DR AlphaFoldDB; O65373; -.
DR SMR; O65373; -.
DR BioGRID; 22998; 1.
DR IntAct; O65373; 1.
DR STRING; 3702.AT1G12060.1; -.
DR PaxDb; O65373; -.
DR PRIDE; O65373; -.
DR ProteomicsDB; 240811; -.
DR EnsemblPlants; AT1G12060.1; AT1G12060.1; AT1G12060.
DR GeneID; 837758; -.
DR Gramene; AT1G12060.1; AT1G12060.1; AT1G12060.
DR KEGG; ath:AT1G12060; -.
DR Araport; AT1G12060; -.
DR TAIR; locus:2008840; AT1G12060.
DR eggNOG; ENOG502RYR9; Eukaryota.
DR HOGENOM; CLU_1302474_0_0_1; -.
DR InParanoid; O65373; -.
DR OMA; CLQRFLH; -.
DR OrthoDB; 1527027at2759; -.
DR PhylomeDB; O65373; -.
DR PRO; PR:O65373; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; O65373; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0051087; F:chaperone binding; IEA:InterPro.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR Gene3D; 1.20.58.120; -; 1.
DR InterPro; IPR040400; BAG5/6/7/8.
DR InterPro; IPR036533; BAG_dom_sf.
DR InterPro; IPR003103; BAG_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR33322; PTHR33322; 1.
DR Pfam; PF02179; BAG; 1.
DR SMART; SM00264; BAG; 1.
DR SUPFAM; SSF63491; SSF63491; 1.
DR PROSITE; PS51035; BAG; 1.
DR PROSITE; PS50096; IQ; 1.
PE 1: Evidence at protein level;
KW Calmodulin-binding; Chaperone; Mitochondrion; Reference proteome;
KW Transit peptide.
FT TRANSIT 1..14
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 15..215
FT /note="BAG family molecular chaperone regulator 5,
FT mitochondrial"
FT /id="PRO_0000415525"
FT DOMAIN 50..79
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 72..149
FT /note="BAG"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00369"
SQ SEQUENCE 215 AA; 24787 MW; 1F1332D8104A0EF3 CRC64;
MKRSRKFSSS TTTTTVIHTF YNDHTTPPAT KEIPIETPLP ATKANVKTNA TAAAARIQSG
YRSYRIRNLY KKISSINREA NRVQSIIQRQ ETVDAIRSDE KERLRMNETL MALLLKLDSV
PGLDPTIREA RRKVSRKIVG MQEILDSISE TKDEIQWWNY NDLGGVDSGQ GGGAWPLYWE
EAVEEEMCRE RGGEEMERFC AQYLGFRCFQ RFLRE
