RS3A_PLAF7
ID RS3A_PLAF7 Reviewed; 262 AA.
AC O97313;
DT 24-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 113.
DE RecName: Full=40S ribosomal protein S3a {ECO:0000255|HAMAP-Rule:MF_03122};
GN ORFNames=MAL3P7.35, PFC1020c;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=10448855; DOI=10.1038/22964;
RA Bowman S., Lawson D., Basham D., Brown D., Chillingworth T., Churcher C.M.,
RA Craig A., Davies R.M., Devlin K., Feltwell T., Gentles S., Gwilliam R.,
RA Hamlin N., Harris D., Holroyd S., Hornsby T., Horrocks P., Jagels K.,
RA Jassal B., Kyes S., McLean J., Moule S., Mungall K.L., Murphy L.,
RA Oliver K., Quail M.A., Rajandream M.A., Rutter S., Skelton J., Squares R.,
RA Squares S., Sulston J.E., Whitehead S., Woodward J.R., Newbold C.,
RA Barrell B.G.;
RT "The complete nucleotide sequence of chromosome 3 of Plasmodium
RT falciparum.";
RL Nature 400:532-538(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
CC -!- SUBUNIT: Component of the small ribosomal subunit. Mature ribosomes
CC consist of a small (40S) and a large (60S) subunit. The 40S subunit
CC contains about 33 different proteins and 1 molecule of RNA (18S). The
CC 60S subunit contains about 49 different proteins and 3 molecules of RNA
CC (25S, 5.8S and 5S). {ECO:0000255|HAMAP-Rule:MF_03122}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03122}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS1 family.
CC {ECO:0000255|HAMAP-Rule:MF_03122}.
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DR EMBL; AL844502; CAB39062.1; -; Genomic_DNA.
DR RefSeq; XP_001351300.1; XM_001351264.1.
DR PDB; 3J7A; EM; 3.20 A; B=1-262.
DR PDB; 3JBN; EM; 4.70 A; B=24-233.
DR PDB; 3JBO; EM; 5.80 A; B=24-233.
DR PDB; 3JBP; EM; 6.70 A; B=24-233.
DR PDB; 6OKK; EM; 3.30 A; B=1-262.
DR PDBsum; 3J7A; -.
DR PDBsum; 3JBN; -.
DR PDBsum; 3JBO; -.
DR PDBsum; 3JBP; -.
DR PDBsum; 6OKK; -.
DR AlphaFoldDB; O97313; -.
DR SMR; O97313; -.
DR IntAct; O97313; 1.
DR STRING; 5833.PFC1020c; -.
DR DrugBank; DB11638; Artenimol.
DR PRIDE; O97313; -.
DR EnsemblProtists; CAB39062; CAB39062; PF3D7_0322900.
DR GeneID; 814544; -.
DR KEGG; pfa:PF3D7_0322900; -.
DR VEuPathDB; PlasmoDB:PF3D7_0322900; -.
DR HOGENOM; CLU_062507_0_1_1; -.
DR InParanoid; O97313; -.
DR OMA; GQNAYTK; -.
DR PhylomeDB; O97313; -.
DR Reactome; R-PFA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-PFA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-PFA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-PFA-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-PFA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-PFA-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-PFA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-PFA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-PFA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR Proteomes; UP000001450; Chromosome 3.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISS:GeneDB.
DR GO; GO:0003735; F:structural constituent of ribosome; ISS:GeneDB.
DR GO; GO:0006412; P:translation; ISS:GeneDB.
DR HAMAP; MF_03122; Ribosomal_S3Ae_euk; 1.
DR InterPro; IPR027500; Ribosomal_S1/3_euk.
DR InterPro; IPR001593; Ribosomal_S3Ae.
DR Pfam; PF01015; Ribosomal_S3Ae; 1.
DR SMART; SM01397; Ribosomal_S3Ae; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_03122"
FT CHAIN 2..262
FT /note="40S ribosomal protein S3a"
FT /id="PRO_0000389336"
FT STRAND 28..33
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 42..48
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 58..61
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 65..67
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 71..74
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 77..79
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 85..87
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 99..103
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 107..113
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 116..118
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 126..128
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 134..136
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 147..149
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 158..178
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 181..188
FT /evidence="ECO:0007829|PDB:3J7A"
FT TURN 189..191
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 192..201
FT /evidence="ECO:0007829|PDB:3J7A"
FT TURN 202..204
FT /evidence="ECO:0007829|PDB:3J7A"
FT STRAND 215..219
FT /evidence="ECO:0007829|PDB:3J7A"
FT HELIX 225..232
FT /evidence="ECO:0007829|PDB:3J7A"
SQ SEQUENCE 262 AA; 30047 MW; A99CDEB43977CCDD CRC64;
MAVGKNKRTS KGKKGGKKKV TDVFTKKEWY DLKAPKMFLV RNFGKTLVTK TIGKKLATDS
LKGRIYEVNL ADLNNDEDQA HKKIKLSCDH IINRDCYTDF CGLSITRDKL CSLIRKGYTL
IEGHTDVKTL DNYHLRMFCI AFTKKRQNQT KSTCYAQTSQ IKKIRKKMVD IMTAEASKVL
LKDLVKKFIP ESIGKEIEKQ CKKIYPLQNV LIRKVKILKR PKLDISKLME LHTDPKEESG
KNVNALPESK EATNILTAEL KH
