ID   143G1_DANRE             Reviewed;         247 AA.
AC   Q6PC29;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=14-3-3 protein gamma-1;
GN   Name=ywhag1; Synonyms=ywhag; ORFNames=zgc:73131;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Retina;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Adapter protein implicated in the regulation of a large
CC       spectrum of both general and specialized signaling pathways. Binds to a
CC       large number of partners, usually by recognition of a phosphoserine or
CC       phosphothreonine motif. Binding generally results in the modulation of
CC       the activity of the binding partner (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer, and heterodimer with other family members.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}.
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DR   EMBL; BC059494; AAH59494.1; -; mRNA.
DR   RefSeq; NP_998187.1; NM_213022.2.
DR   AlphaFoldDB; Q6PC29; -.
DR   SMR; Q6PC29; -.
DR   STRING; 7955.ENSDARP00000074935; -.
DR   PaxDb; Q6PC29; -.
DR   Ensembl; ENSDART00000080486; ENSDARP00000074935; ENSDARG00000067626.
DR   GeneID; 117604; -.
DR   KEGG; dre:117604; -.
DR   CTD; 117604; -.
DR   ZFIN; ZDB-GENE-011115-1; ywhag1.
DR   eggNOG; KOG0841; Eukaryota.
DR   GeneTree; ENSGT01050000244817; -.
DR   HOGENOM; CLU_058290_0_0_1; -.
DR   InParanoid; Q6PC29; -.
DR   OMA; PLCNEER; -.
DR   OrthoDB; 1176818at2759; -.
DR   PhylomeDB; Q6PC29; -.
DR   TreeFam; TF102003; -.
DR   ChiTaRS; ywhag1; zebrafish.
DR   PRO; PR:Q6PC29; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000067626; Expressed in brain and 50 other tissues.
DR   ExpressionAtlas; Q6PC29; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005080; F:protein kinase C binding; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IMP:ZFIN.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR   Gene3D; 1.20.190.20; -; 1.
DR   InterPro; IPR000308; 14-3-3.
DR   InterPro; IPR023409; 14-3-3_CS.
DR   InterPro; IPR036815; 14-3-3_dom_sf.
DR   InterPro; IPR023410; 14-3-3_domain.
DR   PANTHER; PTHR18860; PTHR18860; 1.
DR   Pfam; PF00244; 14-3-3; 1.
DR   PIRSF; PIRSF000868; 14-3-3; 1.
DR   PRINTS; PR00305; 1433ZETA.
DR   SMART; SM00101; 14_3_3; 1.
DR   SUPFAM; SSF48445; SSF48445; 1.
DR   PROSITE; PS00796; 1433_1; 1.
DR   PROSITE; PS00797; 1433_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome.
FT   CHAIN           1..247
FT                   /note="14-3-3 protein gamma-1"
FT                   /id="PRO_0000058614"
FT   SITE            57
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000250"
FT   SITE            132
FT                   /note="Interaction with phosphoserine on interacting
FT                   protein"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   247 AA;  28235 MW;  E572D924CA8DA6A6 CRC64;
     MVDREQLVQK ARLAEQAERY DDMAAAMKSV TELNEALSNE ERNLLSVAYK NVVGARRSSW
     RVISSIEQKT SADGNEKKIE MVRAYREKIE KELETVCQDV LNLLDNFLIK NCGETQHESK
     VFYLKMKGDY YRYLAEVATG EKRAAVVESS EKSYSEAHEI SKEHMQPTHP IRLGLALNYS
     VFYYEIQNAP EQACHLAKTA FDDAIAELDT LNEDSYKDST LIMQLLRDNL TLWTSDQQDD
     EGGEGNN