RS3_AMBME
ID RS3_AMBME Reviewed; 253 AA.
AC P79891;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=40S ribosomal protein S3;
DE EC=4.2.99.18 {ECO:0000250|UniProtKB:P23396};
GN Name=RPS3;
OS Ambystoma mexicanum (Axolotl).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX NCBI_TaxID=8296;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8739028;
RA Bhatia R., Dube D.K., Lemanski L.F.;
RT "Nucleotide sequence and expression of ribosomal protein S3 mRNA during
RT embryogenesis in the Mexican axolotl (Ambystoma mexicanum).";
RL Biochem. Mol. Biol. Int. 38:1079-1085(1996).
CC -!- FUNCTION: Involved in translation as a component of the 40S small
CC ribosomal subunit. Has endonuclease activity and plays a role in repair
CC of damaged DNA. Also involved in other processes including regulation
CC of transcription, translation of its cognate mRNA, spindle formation
CC and chromosome movement during mitosis, and apoptosis.
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-
CC deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-
CC dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-
CC 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-
CC COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695,
CC ChEBI:CHEBI:167181; EC=4.2.99.18;
CC Evidence={ECO:0000250|UniProtKB:P23396};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23396}. Nucleus
CC {ECO:0000250|UniProtKB:P23396}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P23396}. Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P23396}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P23396}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS3 family.
CC {ECO:0000305}.
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DR EMBL; S83098; AAB46849.1; -; mRNA.
DR AlphaFoldDB; P79891; -.
DR SMR; P79891; -.
DR PRIDE; P79891; -.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.1140.32; -; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR004044; KH_dom_type_2.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR001351; Ribosomal_S3_C.
DR InterPro; IPR036419; Ribosomal_S3_C_sf.
DR InterPro; IPR018280; Ribosomal_S3_CS.
DR InterPro; IPR005703; Ribosomal_S3_euk/arc.
DR Pfam; PF07650; KH_2; 1.
DR Pfam; PF00189; Ribosomal_S3_C; 1.
DR SUPFAM; SSF54814; SSF54814; 1.
DR SUPFAM; SSF54821; SSF54821; 1.
DR TIGRFAMs; TIGR01008; uS3_euk_arch; 1.
DR PROSITE; PS50823; KH_TYPE_2; 1.
DR PROSITE; PS00548; RIBOSOMAL_S3; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; DNA damage;
KW DNA repair; DNA-binding; Lyase; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Mitosis; Nucleus; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..253
FT /note="40S ribosomal protein S3"
FT /id="PRO_0000130324"
FT DOMAIN 21..92
FT /note="KH type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00118"
FT REGION 211..253
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 233..253
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 253 AA; 27747 MW; E45126A9B9F114A5 CRC64;
MAVQISKKRK FVADGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG
EKGRRIRELT AVVQKRFGFP EGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY
GVLRFIMESG SKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG
VLGIKVKIML AWDPSGKIGP KKPLPDHVSI VEPKDEILPT TPISEQKGGK PDPQVPQQPP
QQPPAMPPPV PTA
