位置:首页 > 蛋白库 > ABCA8_DICDI
ABCA8_DICDI
ID   ABCA8_DICDI             Reviewed;         837 AA.
AC   Q55BC0; Q8T6I9;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=ABC transporter A family member 8;
DE   AltName: Full=ABC transporter ABCA.8;
GN   Name=abcA8; ORFNames=DDB_G0271138;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC   STRAIN=AX4;
RX   PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA   Anjard C., Loomis W.F.;
RT   "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL   Eukaryot. Cell 1:643-652(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL85301.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF465310; AAL85301.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AAFI02000006; EAL71699.1; -; Genomic_DNA.
DR   RefSeq; XP_645692.1; XM_640600.1.
DR   AlphaFoldDB; Q55BC0; -.
DR   SMR; Q55BC0; -.
DR   STRING; 44689.DDB0216250; -.
DR   PaxDb; Q55BC0; -.
DR   EnsemblProtists; EAL71699; EAL71699; DDB_G0271138.
DR   GeneID; 8617885; -.
DR   KEGG; ddi:DDB_G0271138; -.
DR   dictyBase; DDB_G0271138; abcA8.
DR   eggNOG; KOG0059; Eukaryota.
DR   HOGENOM; CLU_000604_19_5_1; -.
DR   InParanoid; Q55BC0; -.
DR   OMA; LWRNNSA; -.
DR   PhylomeDB; Q55BC0; -.
DR   Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR   Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR   Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR   Reactome; R-DDI-6798695; Neutrophil degranulation.
DR   Reactome; R-DDI-8963896; HDL assembly.
DR   PRO; PR:Q55BC0; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR   GO; GO:0030587; P:sorocarp development; IEA:UniProt.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; PTHR19229; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..837
FT                   /note="ABC transporter A family member 8"
FT                   /id="PRO_0000363840"
FT   TRANSMEM        29..49
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        244..264
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        303..323
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        356..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        393..413
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        455..475
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          516..750
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         553..560
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   837 AA;  93818 MW;  F99D6D0FEBA8523D CRC64;
     MSIGETIHRE FIHLKLLLKK NFLVSIRSYF STIIELLSPI VFVLIFYIIY SYGSAVDYSN
     VSYEQNLPNC IVSVENRCIN LMFSPMNSTC TVEIMKILAK NNNMEIYNYP TDTGPLPNLE
     NTIGFHGGII AMDSLNSTEQ FILAHPNVTL AVVDFENFPL NFTINGVKPN DSLIGFNDFY
     DLSFNVLLNL STSGGFIEPV DYSIPVTTSI QKAIYDFYAI NNQKQIPTIN FDSTQFIEYS
     SVNVVSLFGG LFYYCAIMIS FIFLLYKVAF EKEKNLKQGM VMMGLSRSMY WLSWVITSFT
     IDLIICLLLI AIGAICKLPF FLGTNFLVLL LNFFLFAISS SSMAFFMLTF IGKTKVAIGI
     GMAFFIVGSG LQLTFNSLGS LIFQIIYQTD SNGAAFVRVI LFILPMFHFS KVLTDINDKV
     QSYPTSQFKI SDLNDNLDGS QYGMDYLVPT TGQSLAYMFI LVIVYLSLSA IIEYALSGGF
     SFKTVKHINV PHFDDQDVAN ATNRSLDPSN KSPFIIRGLS KTFNKFLRPS KSVHALKYLS
     LDIQEGTVLG LLGSNGAGKS TTIGILTGIH SPTSGDAIIY GHSVVKDIHS VRKITSVVPQ
     DDILWLELTA MEHLHLFAEL KGIPVRERDF QIAKVLEQVK LTKVANDQCS TFSGGMKRRL
     SVAIGCIGDP KIIFMDEPTT GLDPRSKRRI YTLVKEIKKD KVIILTSHDM HEIEILAQNL
     VILNDGIMVC NGNALQLKTK YGEGYSVQVI AKSLEVIPEI INFVTSSLPY CRFLKQSALQ
     LNFGFPINTD PKIIVNFFKR LESITKDENN NLMRDWSISH SNMDDVFIKV SNKPKLQ
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024