ID   BAGE4_HUMAN             Reviewed;          39 AA.
AC   Q86Y28;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=B melanoma antigen 4;
DE   AltName: Full=Cancer/testis antigen 2.4;
DE            Short=CT2.4;
DE   Flags: Precursor;
GN   Name=BAGE4; Synonyms=MLL3P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Ruault M., Rocchi M., Boyle S., Roizes G., van der Bruggen P., De Sario A.;
RT   "BAGE a family of centromeric genes coding for tumor antigens.";
RL   Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Unknown. Candidate gene encoding tumor antigens.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Not expressed in normal tissues except in testis.
CC       Expressed in melanoma, bladder and lung carcinomas.
CC   -!- MISCELLANEOUS: The ancestral BAGE gene was generated by
CC       juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family
CC       was expanded by juxtacentromeric movement and/or acrocentric exchanges.
CC       BAGE family is composed of expressed genes that map to the
CC       juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed
CC       gene fragments that scattered in the juxtacentromeric regions of
CC       several chromosomes, including chromosomes 9, 13, 18 and 21.
CC   -!- SIMILARITY: Belongs to the BAGE family. {ECO:0000305}.
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DR   EMBL; AF339515; AAO32635.1; -; mRNA.
DR   RefSeq; NP_859055.1; NM_181704.1.
DR   AlphaFoldDB; Q86Y28; -.
DR   BioMuta; HGNC:15730; -.
DR   DMDM; 37537779; -.
DR   MassIVE; Q86Y28; -.
DR   PRIDE; Q86Y28; -.
DR   DNASU; 85317; -.
DR   GeneID; 85317; -.
DR   KEGG; hsa:85317; -.
DR   CTD; 85317; -.
DR   DisGeNET; 85317; -.
DR   GeneCards; BAGE4; -.
DR   HGNC; HGNC:15730; BAGE4.
DR   neXtProt; NX_Q86Y28; -.
DR   PharmGKB; PA25245; -.
DR   PhylomeDB; Q86Y28; -.
DR   PathwayCommons; Q86Y28; -.
DR   SignaLink; Q86Y28; -.
DR   BioGRID-ORCS; 85317; 7 hits in 52 CRISPR screens.
DR   GenomeRNAi; 85317; -.
DR   Pharos; Q86Y28; Tdark.
DR   PRO; PR:Q86Y28; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012530; BAGE-like.
DR   Pfam; PF08180; BAGE; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..39
FT                   /note="B melanoma antigen 4"
FT                   /id="PRO_0000020777"
SQ   SEQUENCE   39 AA;  4230 MW;  0016A0A6D0266FFF CRC64;
     MAAGAVFLAL SAQLLQARLM KEESPVVSWW LEPEDGTAL