ID   BAGE5_HUMAN             Reviewed;          43 AA.
AC   Q86Y27;
DT   03-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=B melanoma antigen 5;
DE   AltName: Full=Cancer/testis antigen 2.5;
DE            Short=CT2.5;
DE   Flags: Precursor;
GN   Name=BAGE5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=12461691; DOI=10.1038/sj.ejhg.5200891;
RA   Ruault M., van der Bruggen P., Brun M.-E., Boyle S., Roizes G.,
RA   De Sario A.;
RT   "New BAGE (B melanoma antigen) genes mapping to the juxtacentromeric
RT   regions of human chromosomes 13 and 21 have a cancer/testis expression
RT   profile.";
RL   Eur. J. Hum. Genet. 10:833-840(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RX   PubMed=12676563; DOI=10.1016/s0888-7543(03)00025-9;
RA   Ruault M., Ventura M., Galtier N., Brun M.-E., Archidiacono N., Roizes G.,
RA   De Sario A.;
RT   "BAGE genes generated by juxtacentromeric reshuffling in the hominidae
RT   lineage are under selective pressure.";
RL   Genomics 81:391-399(2003).
CC   -!- FUNCTION: Unknown. Candidate gene encoding tumor antigens.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Not expressed in normal tissues except in testis.
CC       Expressed in melanoma, bladder and lung carcinomas.
CC   -!- MISCELLANEOUS: The ancestral BAGE gene was generated by
CC       juxtacentromeric reshuffling of the KMT2C/MLL3 gene. The BAGE family
CC       was expanded by juxtacentromeric movement and/or acrocentric exchanges.
CC       BAGE family is composed of expressed genes that map to the
CC       juxtacentromeric regions of chromosomes 13 and 21 and of unexpressed
CC       gene fragments that scattered in the juxtacentromeric regions of
CC       several chromosomes, including chromosomes 9, 13, 18 and 21.
CC   -!- SIMILARITY: Belongs to the BAGE family. {ECO:0000305}.
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DR   EMBL; AF339516; AAO32636.1; -; mRNA.
DR   RefSeq; NP_872290.1; NM_182484.1.
DR   AlphaFoldDB; Q86Y27; -.
DR   STRING; 9606.ENSP00000485185; -.
DR   BioMuta; HGNC:15732; -.
DR   DMDM; 37537778; -.
DR   MassIVE; Q86Y27; -.
DR   PRIDE; Q86Y27; -.
DR   DNASU; 85316; -.
DR   GeneID; 85316; -.
DR   KEGG; hsa:85316; -.
DR   CTD; 85316; -.
DR   GeneCards; BAGE5; -.
DR   HGNC; HGNC:15732; BAGE5.
DR   neXtProt; NX_Q86Y27; -.
DR   PharmGKB; PA25246; -.
DR   PhylomeDB; Q86Y27; -.
DR   PathwayCommons; Q86Y27; -.
DR   SignaLink; Q86Y27; -.
DR   BioGRID-ORCS; 85316; 9 hits in 69 CRISPR screens.
DR   GenomeRNAi; 85316; -.
DR   Pharos; Q86Y27; Tdark.
DR   PRO; PR:Q86Y27; -.
DR   Proteomes; UP000005640; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR012530; BAGE-like.
DR   Pfam; PF08180; BAGE; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..43
FT                   /note="B melanoma antigen 5"
FT                   /id="PRO_0000020778"
SQ   SEQUENCE   43 AA;  4711 MW;  C6F3AACE4012F1A6 CRC64;
     MAAGAVFLAL SAQLLQARLM KEESPVVSWR LEPEDGTALC FIF