BAGP1_ARATH
ID BAGP1_ARATH Reviewed; 594 AA.
AC Q8W4D4; Q9M1A2;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=BAG-associated GRAM protein 1 {ECO:0000303|PubMed:26739014};
GN Name=BAGP1 {ECO:0000303|PubMed:26739014};
GN OrderedLocusNames=At3g59660 {ECO:0000312|Araport:AT3G59660};
GN ORFNames=T16L24.21 {ECO:0000312|EMBL:CAB75463.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000312|EMBL:AAL32719.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP INDUCTION.
RX PubMed=18201690; DOI=10.1016/j.ydbio.2007.11.031;
RA Jiang S.Y., Ramamoorthy R., Ramachandran S.;
RT "Comparative transcriptional profiling and evolutionary analysis of the
RT GRAM domain family in eukaryotes.";
RL Dev. Biol. 314:418-432(2008).
RN [5]
RP FUNCTION, DISRUPTION PHENOTYPE, AND INTERACTION WITH BAG6 AND APCB1.
RX PubMed=26739014; DOI=10.1105/tpc.15.00626;
RA Li Y., Kabbage M., Liu W., Dickman M.B.;
RT "Aspartyl protease-mediated cleavage of BAG6 is necessary for autophagy and
RT fungal resistance in plants.";
RL Plant Cell 28:233-247(2016).
CC -!- FUNCTION: Involved in proteolytic processing of BAG6.
CC {ECO:0000269|PubMed:26739014}.
CC -!- SUBUNIT: Interacts with BAG6 and APCB1. {ECO:0000269|PubMed:26739014}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane
CC protein {ECO:0000255}.
CC -!- INDUCTION: Up-regulated by cold, drought, salinity, abscisic acid and
CC fungal infection. {ECO:0000269|PubMed:18201690}.
CC -!- DISRUPTION PHENOTYPE: Enhanced susceptibility to B.cinerea and
CC permissive fungal growth. {ECO:0000269|PubMed:26739014}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB75463.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL138659; CAB75463.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79952.1; -; Genomic_DNA.
DR EMBL; AY062641; AAL32719.1; -; mRNA.
DR EMBL; BT008357; AAP37716.1; -; mRNA.
DR PIR; T49307; T49307.
DR RefSeq; NP_191525.2; NM_115828.5.
DR AlphaFoldDB; Q8W4D4; -.
DR SMR; Q8W4D4; -.
DR STRING; 3702.AT3G59660.1; -.
DR iPTMnet; Q8W4D4; -.
DR PaxDb; Q8W4D4; -.
DR PRIDE; Q8W4D4; -.
DR ProteomicsDB; 240808; -.
DR EnsemblPlants; AT3G59660.1; AT3G59660.1; AT3G59660.
DR GeneID; 825135; -.
DR Gramene; AT3G59660.1; AT3G59660.1; AT3G59660.
DR KEGG; ath:AT3G59660; -.
DR Araport; AT3G59660; -.
DR TAIR; locus:2097578; AT3G59660.
DR eggNOG; KOG1032; Eukaryota.
DR HOGENOM; CLU_028706_1_0_1; -.
DR InParanoid; Q8W4D4; -.
DR OMA; LIPSWWE; -.
DR OrthoDB; 511910at2759; -.
DR PhylomeDB; Q8W4D4; -.
DR PRO; PR:Q8W4D4; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q8W4D4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR Gene3D; 2.30.29.30; -; 1.
DR Gene3D; 2.60.40.150; -; 1.
DR InterPro; IPR044655; BAGP1-like.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR031968; VASt.
DR PANTHER; PTHR47038; PTHR47038; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF16016; VASt; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00568; GRAM; 1.
DR SUPFAM; SSF49562; SSF49562; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS51778; VAST; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..594
FT /note="BAG-associated GRAM protein 1"
FT /id="PRO_0000436004"
FT TRANSMEM 8..28
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 67..179
FT /note="C2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00041"
FT DOMAIN 231..295
FT /note="GRAM"
FT /evidence="ECO:0000255"
FT DOMAIN 399..572
FT /note="VASt"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01114"
FT REGION 571..594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 594 AA; 66068 MW; A39B90890933AEE5 CRC64;
MVQSAVEVLL PSAWEIEVAV VASVFLIASY WLFAYRGGGD DDVVGVGFDR SRLMQNLDSG
DAFDKDKIGH LRGDTQTNAA YIVKVELLAA KNLIGANLNG TSDPYAIVNC GSEKRFSSMV
PGSRNPMWGE EFNFPTDELP AKINVTIHDW DIIWKSTVLG SVTINVEREG QTGPVWHSLD
SPSGQVCLNI NAIKLPVNAP RAVTGYAGAG RRRVTLDQQG PTIVHQKPGP LQTIFDLLPD
EVVEHSYSCA LERSFLYHGR MYVSAWHICF HSNVFSKQMK VVVPLGDIDE IRRSQHALIN
PAITIILRMG AGGHGVPPLG TPDGRVRYKF ASFWNRNHTL KALQRAVNNY HAMLEVEKKE
RAQSALRAHS SSVKGGGKVQ VKAPEDTAAV PVKFQAFIKE EVLVNIYNDV FASTPEQVLN
VLLADDSTYT NEYRSARKDK NLNIEPWHTA EEYDGQVREI KFRSICNSPM CPPDTAVTEW
QHVVLSPDKK VLVFETVQQP HDVPFGSYFE VHCRWRLEAK DETSSVIDIR VGVHFKKWCL
MQSKIKAGAI DEYKKEVEVM LEVALSYLKS HSSSSSHGDI DKSALSSPTP ENIS
