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BAGP_DROME
ID   BAGP_DROME              Reviewed;         382 AA.
AC   P22809; Q24254; Q6UJA4; Q6UJA5; Q6UJA8; Q6UJA9; Q6UJB1; Q6UJB2; Q9VDA6;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 3.
DT   03-AUG-2022, entry version 165.
DE   RecName: Full=Homeobox protein bagpipe;
DE   AltName: Full=Homeobox protein NK-3;
GN   Name=bap; Synonyms=bgp, NK3; ORFNames=CG7902;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC   TISSUE=Embryo;
RX   PubMed=8101173; DOI=10.1101/gad.7.7b.1325;
RA   Azpiazu N., Frasch M.;
RT   "Tinman and bagpipe: two homeo box genes that determine cell fates in the
RT   dorsal mesoderm of Drosophila.";
RL   Genes Dev. 7:1325-1340(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=F-1461S, F-274F, F-357F, F-517F, F-517S, F-531F, F-611F, F-775F,
RC   F-96S, S-114S, S-1224F, S-174F, S-255S, S-2588S, S-26F, S-377F, S-438S,
RC   S-501F, S-501S, S-510S, S-521F, S-521S, S-549S, S-565F, S-581F, S-94F,
RC   S-968F, and US-255F;
RX   PubMed=15126403; DOI=10.1534/genetics.166.4.1845;
RA   Balakirev E.S., Ayala F.J.;
RT   "Nucleotide variation in the tinman and bagpipe homeobox genes of
RT   Drosophila melanogaster.";
RL   Genetics 166:1845-1856(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 95-288.
RC   STRAIN=Canton-S;
RX   PubMed=2573058; DOI=10.1073/pnas.86.20.7716;
RA   Kim Y., Nirenberg M.;
RT   "Drosophila NK-homeobox genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:7716-7720(1989).
CC   -!- FUNCTION: Involved in the determination of cell fates in the dorsal
CC       mesoderm. {ECO:0000269|PubMed:8101173}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Is expressed in a segmented pattern in visceral
CC       muscle and in a subset of cardiac muscles. Loss of activity results in
CC       segmental gaps in midgut visceral muscle. {ECO:0000269|PubMed:8101173}.
CC   -!- SIMILARITY: Belongs to the NK-3 homeobox family. {ECO:0000305}.
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DR   EMBL; L17133; AAC37165.1; -; mRNA.
DR   EMBL; AY369088; AAQ73793.1; -; Genomic_DNA.
DR   EMBL; AY369089; AAQ73794.1; -; Genomic_DNA.
DR   EMBL; AY369090; AAQ73795.1; -; Genomic_DNA.
DR   EMBL; AY369091; AAQ73796.1; -; Genomic_DNA.
DR   EMBL; AY369092; AAQ73797.1; -; Genomic_DNA.
DR   EMBL; AY369093; AAQ73798.1; -; Genomic_DNA.
DR   EMBL; AY369094; AAQ73799.1; -; Genomic_DNA.
DR   EMBL; AY369095; AAQ73800.1; -; Genomic_DNA.
DR   EMBL; AY369096; AAQ73801.1; -; Genomic_DNA.
DR   EMBL; AY369097; AAQ73802.1; -; Genomic_DNA.
DR   EMBL; AY369098; AAQ73803.1; -; Genomic_DNA.
DR   EMBL; AY369099; AAQ73804.1; -; Genomic_DNA.
DR   EMBL; AY369100; AAQ73805.1; -; Genomic_DNA.
DR   EMBL; AY369101; AAQ73806.1; -; Genomic_DNA.
DR   EMBL; AY369102; AAQ73807.1; -; Genomic_DNA.
DR   EMBL; AY369103; AAQ73808.1; -; Genomic_DNA.
DR   EMBL; AY369104; AAQ73809.1; -; Genomic_DNA.
DR   EMBL; AY369105; AAQ73810.1; -; Genomic_DNA.
DR   EMBL; AY369106; AAQ73811.1; -; Genomic_DNA.
DR   EMBL; AY369107; AAQ73812.1; -; Genomic_DNA.
DR   EMBL; AY369108; AAQ73813.1; -; Genomic_DNA.
DR   EMBL; AY369109; AAQ73814.1; -; Genomic_DNA.
DR   EMBL; AY369110; AAQ73815.1; -; Genomic_DNA.
DR   EMBL; AY369111; AAQ73816.1; -; Genomic_DNA.
DR   EMBL; AY369112; AAQ73817.1; -; Genomic_DNA.
DR   EMBL; AY369113; AAQ73818.1; -; Genomic_DNA.
DR   EMBL; AY369114; AAQ73819.1; -; Genomic_DNA.
DR   EMBL; AY369115; AAQ73820.1; -; Genomic_DNA.
DR   EMBL; AE014297; AAF55891.1; -; Genomic_DNA.
DR   EMBL; M27291; AAA28618.1; -; Genomic_DNA.
DR   PIR; C33976; C33976.
DR   RefSeq; NP_732637.1; NM_169958.2.
DR   AlphaFoldDB; P22809; -.
DR   SMR; P22809; -.
DR   BioGRID; 67503; 17.
DR   IntAct; P22809; 11.
DR   STRING; 7227.FBpp0083486; -.
DR   PaxDb; P22809; -.
DR   EnsemblMetazoa; FBtr0084087; FBpp0083486; FBgn0004862.
DR   GeneID; 42537; -.
DR   KEGG; dme:Dmel_CG7902; -.
DR   UCSC; CG7902-RA; d. melanogaster.
DR   CTD; 42537; -.
DR   FlyBase; FBgn0004862; bap.
DR   VEuPathDB; VectorBase:FBgn0004862; -.
DR   eggNOG; KOG0842; Eukaryota.
DR   HOGENOM; CLU_044250_0_0_1; -.
DR   InParanoid; P22809; -.
DR   OMA; LNMESAG; -.
DR   OrthoDB; 858478at2759; -.
DR   PhylomeDB; P22809; -.
DR   SignaLink; P22809; -.
DR   BioGRID-ORCS; 42537; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 42537; -.
DR   PRO; PR:P22809; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0004862; Expressed in crop (Drosophila) and 15 other tissues.
DR   ExpressionAtlas; P22809; baseline and differential.
DR   Genevisible; P22809; DM.
DR   GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR   GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IGI:FlyBase.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007498; P:mesoderm development; IEP:FlyBase.
DR   GO; GO:0001710; P:mesodermal cell fate commitment; TAS:FlyBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR   GO; GO:0007522; P:visceral muscle development; NAS:FlyBase.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..382
FT                   /note="Homeobox protein bagpipe"
FT                   /id="PRO_0000049016"
FT   DNA_BIND        175..234
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          27..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..178
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          314..382
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        39..60
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        147..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..336
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..364
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         62
FT                   /note="I -> A (in strain: F-96S, F-274F, S-26F, S-94F, S-
FT                   377F, S-510S, S-521F, S-521S, S-565F, S-968F and US-255F)"
FT   VARIANT         62
FT                   /note="I -> V (in strain: F-775F, S-549S and S-1224F)"
FT   VARIANT         74
FT                   /note="G -> S (in strain: F-775F, S-549S and S-1224F)"
FT   VARIANT         327
FT                   /note="T -> N (in strain: S-26F, S-94F, S-438S, S-510S and
FT                   S-521F)"
FT   VARIANT         342
FT                   /note="G -> S (in strain: S-26F, S-94F, S-438S, S-510S and
FT                   S-521F)"
FT   VARIANT         367
FT                   /note="S -> SGAES (in strain: S-521S, S-968F and US-255F)"
FT   VARIANT         369
FT                   /note="H -> Q (in strain: F-611F)"
FT   CONFLICT        251
FT                   /note="V -> I (in Ref. 1; AAC37165)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   382 AA;  41993 MW;  49A8DFE19A2022B9 CRC64;
     MLNMESAGVS AAMAGLSKSL TTPFSINDIL TRSNPETRRM SSVDSEPEPE KLKPSSDRER
     SISKSPPLCC RDLGLYKLTQ PKEIQPSARQ PSNYLQYYAA AMDNNNHHHQ ATGTSNSSAA
     DYMQRKLAYF GSTLAAPLDM RRCTSNDSDC DSPPPLSSSP SESPLSHDGS GLSRKKRSRA
     AFSHAQVFEL ERRFAQQRYL SGPERSEMAK SLRLTETQVK IWFQNRRYKT KRKQIQQHEA
     ALLGASKRVP VQVLVREDGS TTYAHMAAPG AGHGLDPALI NIYRHQLQLA YGGLPLPQMQ
     MPFPYFYPQH KVPQPIPPPT QSSSFVTASS ASSSPVPIPI PGAVRPQRTP CPSPNGQMMS
     VESGAESVHS AAEDVDENVE ID
 
 
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