BAG_STRAG
ID BAG_STRAG Reviewed; 1164 AA.
AC P27951;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 25-MAY-2022, entry version 111.
DE RecName: Full=IgA FC receptor;
DE AltName: Full=Beta antigen;
DE Short=B antigen;
DE Flags: Precursor;
GN Name=bag;
OS Streptococcus agalactiae.
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=1311;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 38-48.
RC STRAIN=LA239;
RX PubMed=1857207; DOI=10.1111/j.1365-2958.1991.tb00757.x;
RA Jerlstroem P.G., Chhatwal G.S., Timmis K.N.;
RT "The IgA-binding beta antigen of the c protein complex of Group B
RT streptococci: sequence determination of its gene and detection of two
RT binding regions.";
RL Mol. Microbiol. 5:843-849(1991).
RN [2]
RP IDENTIFICATION OF IG-LIKE DOMAIN.
RX PubMed=8880921; DOI=10.1002/pro.5560050923;
RA Bateman A., Eddy S.R., Chothia C.;
RT "Members of the immunoglobulin superfamily in bacteria.";
RL Protein Sci. 5:1939-1942(1996).
CC -!- SUBCELLULAR LOCATION: Secreted, cell wall {ECO:0000255|PROSITE-
CC ProRule:PRU00477}; Peptidoglycan-anchor {ECO:0000255|PROSITE-
CC ProRule:PRU00477}.
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DR EMBL; X59771; CAA42442.1; -; Genomic_DNA.
DR PIR; S15330; FCSOAG.
DR PDB; 5WAH; NMR; -; A=92-189.
DR PDB; 6V3P; X-ray; 3.25 A; C/D=428-540.
DR PDBsum; 5WAH; -.
DR PDBsum; 6V3P; -.
DR AlphaFoldDB; P27951; -.
DR BMRB; P27951; -.
DR SMR; P27951; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR Gene3D; 1.20.140.130; -; 1.
DR Gene3D; 1.20.81.20; -; 2.
DR Gene3D; 2.60.40.10; -; 1.
DR InterPro; IPR031792; GAG_BD.
DR InterPro; IPR038349; GAG_BD_sf.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR019931; LPXTG_anchor.
DR InterPro; IPR007756; RICH.
DR InterPro; IPR038183; RICH_sf.
DR InterPro; IPR005877; YSIRK_signal_dom.
DR Pfam; PF16828; GAGBD; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR Pfam; PF05062; RICH; 1.
DR Pfam; PF04650; YSIRK_signal; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR TIGRFAMs; TIGR01168; YSIRK_signal; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell wall; Direct protein sequencing; Immunoglobulin domain;
KW Peptidoglycan-anchor; Receptor; Secreted; Signal.
FT SIGNAL 1..37
FT /evidence="ECO:0000269|PubMed:1857207"
FT CHAIN 38..1135
FT /note="IgA FC receptor"
FT /id="PRO_0000005595"
FT PROPEP 1136..1164
FT /note="Removed by sortase"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT /id="PRO_0000005596"
FT DOMAIN 434..534
FT /note="Ig-like"
FT REGION 54..75
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 199..438
FT /note="IgA-binding"
FT /evidence="ECO:0000255"
FT REGION 439..826
FT /note="IgA-binding"
FT /evidence="ECO:0000255"
FT REGION 536..567
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1132..1136
FT /note="LPXTG sorting signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT COMPBIAS 59..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 536..561
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..939
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1135
FT /note="Pentaglycyl murein peptidoglycan amidated threonine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00477"
FT HELIX 105..124
FT /evidence="ECO:0007829|PDB:5WAH"
FT HELIX 129..141
FT /evidence="ECO:0007829|PDB:5WAH"
FT HELIX 145..174
FT /evidence="ECO:0007829|PDB:5WAH"
FT STRAND 437..440
FT /evidence="ECO:0007829|PDB:6V3P"
FT STRAND 453..460
FT /evidence="ECO:0007829|PDB:6V3P"
FT STRAND 466..468
FT /evidence="ECO:0007829|PDB:6V3P"
FT HELIX 470..476
FT /evidence="ECO:0007829|PDB:6V3P"
FT STRAND 484..486
FT /evidence="ECO:0007829|PDB:6V3P"
FT STRAND 493..502
FT /evidence="ECO:0007829|PDB:6V3P"
FT STRAND 511..518
FT /evidence="ECO:0007829|PDB:6V3P"
FT STRAND 523..531
FT /evidence="ECO:0007829|PDB:6V3P"
SQ SEQUENCE 1164 AA; 131052 MW; 65DE94AF720A5474 CRC64;
MFKSNYERKM RYSIRKFSVG VASVAVASLF MGSVAHASEL VKDDSVKTTE VAAKPYPSMA
QTDQGNNSSS SELETTKMEI PTTDIKKAVE PVEKTAGETS ATDTGKREKQ LQQWKNNLKN
DVDNTILSHE QKNEFKTKID ETNDSDALLE LENQFNETNR LLHIKQHEEV EKDKKAKQQK
TLKQSDTKVD LSNIDKELNH QKSQVEKMAE QKGITNEDKD SMLKKIEDIR KQAQQADKKE
DAEVKVREEL GKLFSSTKAG LDQEIQEHVK KETSSEENTQ KVDEHYANSL QNLAQKSLEE
LDKATTNEQA TQVKNQFLEN AQKLKEIQPL IKETNVKLYK AMSESLEQVE KELKHNSEAN
LEDLVAKSKE IVREYEGKLN QSKNLPELKQ LEEEAHSKLK QVVEDFRKKF KTSEQVTPKK
RVKRDLAANE NNQQKIELTV SPENITVYEG EDVKFTVTAK SDSKTTLDFS DLLTKYNPSV
SDRISTNYKT NTDNHKIAEI TIKNLKLNES QTVTLKAKDD SGNVVEKTFT ITVQKKEEKQ
VPKTPEQKDS KTEEKVPQEP KSNDKNQLQE LIKSAQQELE KLEKAIKELM EQPEIPSNPE
YGIQKSIWES QKEPIQEAIT SFKKIIGDSS SKYYTEHYFN KYKSDFMNYQ LHAQMEMLTR
KVVQYMNKYP DNAEIKKIFE SDMKRTKEDN YGSLENDALK GYFEKYFLTP FNKIKQIVDD
LDKKVEQDQP APIPENSEMD QAKEKAKIAV SKYMSKVLDG VHQHLQKKNN SKIVDLFKEL
EAIKQQTIFD IDNAKTEVEI DNLVHDAFSK MNATVAKFQK GLETNTPETP DTPKIPELPQ
APDTPQAPDT PHVPESPKAP EAPRVPESPK TPEAPHVPES PKAPEAPRVP ESPKTPEAPH
VPESPKTPEA PKIPEPPKTP DVPKLPDVPK LPDVPKLPDA PKLPDGLNKV GQAVFTSTDG
NTKVTVVFDK PTDADKLHLK EVTTKELADK IAHKTGGGTV RVFDLSLSKG GKETHVNGER
TVRLALGQTG SDVHVYHVKE NGDLERIPSK VENGQVVFKT NHFSLFAIKT LSKDQNVTPP
KQTKPSTQGS QVEIAESQTG KFQSKAANHK ALATGNETVA KGNPTSTTEK KLPYTGVASN
LVLEIMGLLG LIGTSFIAMK RRKS
