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BAHC1_HUMAN
ID   BAHC1_HUMAN             Reviewed;        2639 AA.
AC   Q9P281; A0A075B747; Q5U629;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 4.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=BAH and coiled-coil domain-containing protein 1 {ECO:0000305};
DE   AltName: Full=Bromo adjacent homology domain-containing protein 2;
DE            Short=BAH domain-containing protein 2;
GN   Name=BAHCC1 {ECO:0000312|HGNC:HGNC:29279};
GN   Synonyms=BAHD2, KIAA1447 {ECO:0000303|PubMed:10819331};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 745-2465, AND VARIANTS ALA-1168
RP   AND ALA-1678.
RC   TISSUE=Brain;
RX   PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA   Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT   "Prediction of the coding sequences of unidentified human genes. XVII. The
RT   complete sequences of 100 new cDNA clones from brain which code for large
RT   proteins in vitro.";
RL   DNA Res. 7:143-150(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2451-2639.
RC   TISSUE=Pancreas;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Embryonic kidney;
RX   PubMed=17525332; DOI=10.1126/science.1140321;
RA   Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA   Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA   Gygi S.P., Elledge S.J.;
RT   "ATM and ATR substrate analysis reveals extensive protein networks
RT   responsive to DNA damage.";
RL   Science 316:1160-1166(2007).
RN   [6]
RP   ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-222, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=19608861; DOI=10.1126/science.1175371;
RA   Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C.,
RA   Olsen J.V., Mann M.;
RT   "Lysine acetylation targets protein complexes and co-regulates major
RT   cellular functions.";
RL   Science 325:834-840(2009).
RN   [7]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-2274, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
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DR   EMBL; AC110285; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC139149; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC213194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AADB02019016; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AB040880; BAA95971.1; -; mRNA.
DR   EMBL; BC033222; AAH33222.1; -; mRNA.
DR   CCDS; CCDS74173.1; -.
DR   RefSeq; NP_001278253.1; NM_001291324.1.
DR   AlphaFoldDB; Q9P281; -.
DR   SMR; Q9P281; -.
DR   BioGRID; 121648; 21.
DR   IntAct; Q9P281; 16.
DR   STRING; 9606.ENSP00000462154; -.
DR   iPTMnet; Q9P281; -.
DR   PhosphoSitePlus; Q9P281; -.
DR   BioMuta; BAHCC1; -.
DR   DMDM; 205371795; -.
DR   EPD; Q9P281; -.
DR   jPOST; Q9P281; -.
DR   MassIVE; Q9P281; -.
DR   PaxDb; Q9P281; -.
DR   PeptideAtlas; Q9P281; -.
DR   PRIDE; Q9P281; -.
DR   ProteomicsDB; 83747; -.
DR   Antibodypedia; 75308; 11 antibodies from 6 providers.
DR   Ensembl; ENST00000584436.7; ENSP00000462154.4; ENSG00000266074.10.
DR   GeneID; 57597; -.
DR   KEGG; hsa:57597; -.
DR   CTD; 57597; -.
DR   DisGeNET; 57597; -.
DR   GeneCards; BAHCC1; -.
DR   HGNC; HGNC:29279; BAHCC1.
DR   HPA; ENSG00000266074; Low tissue specificity.
DR   MIM; 617646; gene.
DR   neXtProt; NX_Q9P281; -.
DR   OpenTargets; ENSG00000266074; -.
DR   PharmGKB; PA128394719; -.
DR   VEuPathDB; HostDB:ENSG00000266074; -.
DR   eggNOG; KOG1886; Eukaryota.
DR   GeneTree; ENSGT00940000160116; -.
DR   InParanoid; Q9P281; -.
DR   OrthoDB; 11077at2759; -.
DR   PhylomeDB; Q9P281; -.
DR   PathwayCommons; Q9P281; -.
DR   SignaLink; Q9P281; -.
DR   BioGRID-ORCS; 57597; 9 hits in 231 CRISPR screens.
DR   ChiTaRS; BAHCC1; human.
DR   GenomeRNAi; 57597; -.
DR   Pharos; Q9P281; Tdark.
DR   PRO; PR:Q9P281; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9P281; protein.
DR   Bgee; ENSG00000266074; Expressed in right hemisphere of cerebellum and 111 other tissues.
DR   ExpressionAtlas; Q9P281; baseline and differential.
DR   GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR   Gene3D; 2.30.30.490; -; 1.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   Pfam; PF01426; BAH; 1.
DR   SMART; SM00439; BAH; 1.
DR   PROSITE; PS51038; BAH; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..2639
FT                   /note="BAH and coiled-coil domain-containing protein 1"
FT                   /id="PRO_0000312118"
FT   DOMAIN          2513..2633
FT                   /note="BAH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT   REGION          23..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          84..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          188..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          669..702
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          716..746
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          939..1047
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1104..1331
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1457..1513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1582..1666
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1722..1776
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1868..1893
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2057..2119
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2317..2336
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2348..2383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2432..2472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1439..1473
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        195..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..696
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        945..964
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        976..1016
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1104..1126
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1223..1237
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1248..1275
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1307..1322
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1457..1480
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1868..1890
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2348..2375
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        2442..2468
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         222
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0007744|PubMed:19608861"
FT   MOD_RES         2274
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VARIANT         272
FT                   /note="A -> T (in dbSNP:rs12952981)"
FT                   /id="VAR_061559"
FT   VARIANT         1168
FT                   /note="T -> A (in dbSNP:rs7213444)"
FT                   /evidence="ECO:0000269|PubMed:10819331"
FT                   /id="VAR_059589"
FT   VARIANT         1434
FT                   /note="R -> Q (in dbSNP:rs35572189)"
FT                   /id="VAR_061560"
FT   VARIANT         1678
FT                   /note="T -> A (in dbSNP:rs12601317)"
FT                   /evidence="ECO:0000269|PubMed:10819331"
FT                   /id="VAR_061561"
FT   VARIANT         2029
FT                   /note="V -> I (in dbSNP:rs34680524)"
FT                   /id="VAR_061562"
FT   VARIANT         2510
FT                   /note="R -> C (in dbSNP:rs8746)"
FT                   /id="VAR_050685"
SQ   SEQUENCE   2639 AA;  280016 MW;  3A21114C7ACF1D9D CRC64;
     MDGRDFAPPP HLLSERGSLG HRSAAAAARL APAGPAAQPP AHFQPGKYFP SPLPMASHTA
     SSRLMGSSPA SSFMGSFLTS SLGSAASTHP SGPSSSPPEQ AYRGSHPTTS QIWFSHSHEA
     PGYPRFSGSL ASTFLPVSHL DHHGNSNVLY GQHRFYGTQK DNFYLRNLPP QPTLLPANHN
     FPSVARAAPA HPMGSCSRDR DRGEAGSLQK GPKDFDRFLV GKELGREKAG KAAEGKERPA
     AEEDGGKERH KLVLPVPADG HCREGGPAPR GACEGRPKHL TSCLLNTKVL NGEMGRAALA
     SCAGGMLGRP GTGVVTSGRC AKEAAGPPEP GPAFSECLER RQMLHHTASY AGPPPPLSTA
     AGSFPCLQLH GGPDGLCPLQ DKAPRDLKAS GPTFVPSVGH LADKGRPFQA AEACAVAGEG
     KDRHLEGTMA PDHAAPYGVS YAHLKAEGKG ERRPGGFEAA LNPRLKGLDY LSSAGPEASF
     PGLPKSGLDK SGYFELPTSS QDCARPGHQD PLGGKAPQAC CTLDKTVGKE APAGPPGAQK
     VARIRHQQHL MAAEVEQGGI GAEAKRKSLE LASLGYSGPH LPPWGVQAGQ GTAMAISEER
     KAGAYLDPFG SGLQQAALLP QELPAPPDEV SAMKNLLKYS SQALVVGQKA PLVGLGGLKA
     SCIQQEAKFL SSKGPGQSER PDCARSREHD TTHGDGEVRQ PPVGIAVALA RQKDTVSRSE
     AAYGTNTARQ GRAAPAFKGG GGPRSTHALD LEAEEERTRL CDDRLGLASR ELLLQDSKDR
     VEFARIHPPS SCPGDLAPHL MMQSGQLGGD PAPHTHPHPP WLPRTRSPSL WMGGHSYGLG
     HPALHQNLPP GFPASVAGPV PSVFPLPQDA PTQLVILPSE PTPHSAPHAL ADVMDQASLW
     PPMYGGRGPA SHMQHPGQLP VYSRPQLLRQ QELYALQQQR AAQFQRKPED QHLDLEEPAQ
     EKAPKSTHKP VALTPTAPGA PSPAAGPTKL PPCCHPPDPK PPASSPTPPP RPSAPCTLNV
     CPASSPGPGS RVRSAEEKNG EGQQSTADII TSEPVARAHS VAHAGLEFLA SNDPSTSASQ
     SFGITDLPPG YLRPMAGLGF SLPSDVHSSN LEDPETMQTT APGAQPEPTR TFLPGEPPPC
     SPRSLEEPGL LSGAREATQD LAATPYPTER GPQGKAADPS PLEGLQELQC AALLEAGGPE
     ATGQAHSTQG GAREERSREE GEQGPSSGAS SQVLEQRAGS PGALEDEGEQ PAPEEDELEE
     DELGQQSMED SEEDCGGAPD NSHPPRALPG LDALVAATIN LGDLPSDSPP DPQPPAASGP
     PSTVPLPHSS GIHGIALLSE LADLAIQRQR SERTVPEEEE DVLAFNLQHL ATLATAWSLV
     EAAGLDSSTA PAQPPTANPC SGPRLTPRMQ ILQRKDTWTP KTKPVCPLKA AIDRLDTQEV
     GMRVRLAELQ RRYKEKQREL ARLQRKHDHE RDESSRSPAR RGPGRPRKRK HSSSLPAPRP
     TGPLPRSDGK KVKAVRTSLG LLCAELRGGS GGEPAKKRSK LERSVYAGLQ TASVEKAQCK
     KSSCQGGLAP SVAHRVAQLK PKVKSKGLPT GLSSFQQKEA TPGGRIREKL SRAKSAKVSG
     ATRHPQPKGH GSRETPRCPA QPSVAASQEA GSGYDSEDCE GLLGTEAPPR EAGLLLHTGA
     SVAVLGPSPS SVVKMEANQK AKKKKERQGL LGACRLSSPE SEVKIKRRSV KAKVGTTLER
     APGQRPPGAL GKKKAKGKAK GSLRAEPGAT PSRDALFNPS RAFACREEGS QLASERLKRA
     TRKGTVLQPV LRRKNGALSI TLATRNAKAI LGKGRKLSKV KHKAGKQGKG RAVSRLLESF
     AVEEDFEFDD NSSFSEEEED EEEEEEDSGP LSAEQSAALA RSCAIHKEDL RDGLPVLIPK
     EDSLLYAGSV RTLQPPDIYS IVIEGERGNR QRIYSLEQLL QEAVLDVRPQ SSRYLPPGTR
     VCAYWSQKSR CLYPGNVVRG ASGDEDEDLD SVVVEFDDGD TGHIAVSNVR LLPPDFKIQC
     TEPSPALLVS SSCRRTKKVS SEAPPPSEAA TPSLSPKAQD GPEALKTPGK KSISKDKAGK
     AELLTSGAKS PTGASDHFLG RRGSPLLSWS AVAQTKRKAV AAASKGPGVL QNLFQLNGSS
     KKLRAREALF PVHSVATPIF GNGFRADSFS SLASSYAPFV GGTGPGLPRG AHKLLRAKKA
     ERVEAEKGGR RRAGGEFLVK LDHEGVTSPK NKTCKALLMG DKDFSPKLGR PLPSPSYVHP
     ALVGKDKKGR APIPPLPMGL ALRKYAGQAE FPLPYDSDCH SSFSDEDEDG PGLAAGVPSR
     FLARLSVSSS SSGSSTSSSS GSVSTSSLCS SDNEDSSYSS DDEDPALLLQ TCLTHPVPTL
     LAQPEALRSK GSGPHAHAQR CFLSRATVAG TGAGSGPSSS SKSKLKRKEA LSFSKAKELS
     RRQRPPSVEN RPKISAFLPA RQLWKWSGNP TQRRGMKGKA RKLFYKAIVR GEETLRVGDC
     AVFLSAGRPN LPYIGRIESM WESWGSNMVV KVKWFYHPEE TKLGKRQCDG KNALYQSCHE
     DENDVQTISH KCQVVAREQY EQMARSRKCQ DRQDLYYLAG TYDPTTGRLV TADGVPILC
 
 
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