ABCA9_DICDI
ID ABCA9_DICDI Reviewed; 845 AA.
AC Q54DT1; Q8T5Z8; Q8T6I8;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=ABC transporter A family member 9;
DE AltName: Full=ABC transporter ABCA.9;
GN Name=abcA9; Synonyms=abcA12; ORFNames=DDB_G0291980;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-845, AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AAFI02000187; EAL61346.1; -; Genomic_DNA.
DR EMBL; AF465311; AAL85302.1; -; Genomic_DNA.
DR EMBL; AF491005; AAL99042.1; -; Genomic_DNA.
DR RefSeq; XP_629791.1; XM_629789.1.
DR AlphaFoldDB; Q54DT1; -.
DR SMR; Q54DT1; -.
DR PaxDb; Q54DT1; -.
DR EnsemblProtists; EAL61346; EAL61346; DDB_G0291980.
DR GeneID; 8628468; -.
DR KEGG; ddi:DDB_G0291980; -.
DR dictyBase; DDB_G0291980; abcA9.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_000604_19_5_1; -.
DR InParanoid; Q54DT1; -.
DR OMA; YWIVTYL; -.
DR PhylomeDB; Q54DT1; -.
DR PRO; PR:Q54DT1; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..845
FT /note="ABC transporter A family member 9"
FT /id="PRO_0000363841"
FT TRANSMEM 33..53
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 192..212
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 292..312
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..338
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 347..367
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 417..437
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 531..762
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 565..572
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 845 AA; 96318 MW; CE27675E1D7F99D6 CRC64;
MWGASDKKYK SNQFRAMFFK NATFIKRQKC SLCVQISIPL ILVIILVIVN FWVKSQIGSL
QTNGGKLMNS TSTYQYNSLT FGYMLSVNEN NITEIGYKDS DGSGSGLLNY TPQLYIPAFK
AYTPFFVPFA SVENMDDKIL AMKENATFES LSSETLPLSA LIFNDFNVNN RSLDYTIQCE
EQSRYSFYPY EAFVAFSMNT MTTTILNYFL GGNGTIYKSN IATLPYYQQS TTIDIASLLG
GSFYPFALSF IMPLFIYSIV YEKQEKLRDL SLMMGLKIRN YWFMTYIFNF LIYFIIIVFV
VGVSSIFGFA VFVKGSQFAM FLFLFAWGNS MITFSFFLST FFKKTRAASI FGYFLVIIAV
NLNSILSYQV FKDSTPPVPY YWIPLLAFYR GMSQLSTQCG IDLCPEWSAY TWEFEMSKII
FWLYIDAIVY LLIALYLDQV LPREFGVPSH PLFFLKPILN LFKNKDNDKS NTINGGSGGG
RRFSETSSLI NSADFDVENN NGEQEIVEDE DVLEEKEMII NRRYDPNEMT VIIEGLTKHY
VGRPKPSVDN LYLSVRKGEV LGFLGANGAG KTTTISMLTG LYTPTSGTAH VAGLDIRYDM
DNIHHVIGVA MQFDIFWEDL SCVETLLYFT RLKGVPPERE IQSVESILKE VNLFEVKERL
VKELSGGMKR RLSFAVAMTG DSSIIFLDEP STGISSELRR DLWRTINDLK KNRSIILTTH
SMEEADVLSS RIAIISQGKL QCIGTQNHLK AKFGDGYSVR INVEEPYINT HNPTELITKF
SPQAVLTESF DGSYNYRFPK NTVISDLYQY LVSHKYDHHL QEWSFSQTSL EDVFLKISAN
DDTIN
