BAHC1_MOUSE
ID BAHC1_MOUSE Reviewed; 2643 AA.
AC Q3UHR0; A2AS78; Q0KK52; Q0KK57; Q3TPP4; Q3UHG9; Q6GQV4; Q6P9S8; Q6PFC9;
AC Q80UX2;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=BAH and coiled-coil domain-containing protein 1;
GN Name=Bahcc1; Synonyms=Kiaa1447;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF
RP 121-1521.
RC STRAIN=BALB/cCrSlc; TISSUE=Brain;
RX PubMed=16807365; DOI=10.1096/fj.06-5952fje;
RA Nakayama M., Iida M., Koseki H., Ohara O.;
RT "A gene-targeting approach for functional characterization of KIAA genes
RT encoding extremely large proteins.";
RL FASEB J. 20:1718-1720(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain, and Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1395-2643.
RC STRAIN=C57BL/6J; TISSUE=Fetal brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH60615.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAH72602.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAE27888.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE27888.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAE37691.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB257855; BAF03198.1; -; mRNA.
DR EMBL; AB257860; BAF03203.1; -; Genomic_DNA.
DR EMBL; AK147250; BAE27797.1; -; mRNA.
DR EMBL; AK147400; BAE27888.1; ALT_SEQ; mRNA.
DR EMBL; AK164229; BAE37691.1; ALT_INIT; mRNA.
DR EMBL; AL928567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC044873; AAH44873.1; -; mRNA.
DR EMBL; BC057623; AAH57623.1; -; mRNA.
DR EMBL; BC060615; AAH60615.1; ALT_INIT; mRNA.
DR EMBL; BC072602; AAH72602.1; ALT_INIT; mRNA.
DR CCDS; CCDS83943.1; -.
DR RefSeq; NP_001334550.1; NM_001347621.1.
DR RefSeq; NP_940815.3; NM_198423.3.
DR RefSeq; XP_011247356.1; XM_011249054.2.
DR PDB; 6VIL; X-ray; 3.30 A; A/B/C/D/E/F/G/H=2485-2643.
DR PDBsum; 6VIL; -.
DR AlphaFoldDB; Q3UHR0; -.
DR SMR; Q3UHR0; -.
DR STRING; 10090.ENSMUSP00000043643; -.
DR iPTMnet; Q3UHR0; -.
DR PhosphoSitePlus; Q3UHR0; -.
DR MaxQB; Q3UHR0; -.
DR PaxDb; Q3UHR0; -.
DR PRIDE; Q3UHR0; -.
DR ProteomicsDB; 277176; -.
DR Antibodypedia; 75308; 11 antibodies from 6 providers.
DR Ensembl; ENSMUST00000118987; ENSMUSP00000112784; ENSMUSG00000039741.
DR Ensembl; ENSMUST00000122148; ENSMUSP00000112827; ENSMUSG00000039741.
DR GeneID; 268515; -.
DR KEGG; mmu:268515; -.
DR UCSC; uc007msd.2; mouse.
DR CTD; 57597; -.
DR MGI; MGI:2679272; Bahcc1.
DR VEuPathDB; HostDB:ENSMUSG00000039741; -.
DR eggNOG; KOG1886; Eukaryota.
DR GeneTree; ENSGT00940000160116; -.
DR HOGENOM; CLU_000573_0_0_1; -.
DR InParanoid; Q3UHR0; -.
DR PhylomeDB; Q3UHR0; -.
DR TreeFam; TF336007; -.
DR BioGRID-ORCS; 268515; 0 hits in 59 CRISPR screens.
DR ChiTaRS; Bahcc1; mouse.
DR PRO; PR:Q3UHR0; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q3UHR0; protein.
DR Bgee; ENSMUSG00000039741; Expressed in manus and 156 other tissues.
DR ExpressionAtlas; Q3UHR0; baseline and differential.
DR Genevisible; Q3UHR0; MM.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR Gene3D; 2.30.30.490; -; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR Pfam; PF01426; BAH; 1.
DR SMART; SM00439; BAH; 1.
DR PROSITE; PS51038; BAH; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Coiled coil; Reference proteome.
FT CHAIN 1..2643
FT /note="BAH and coiled-coil domain-containing protein 1"
FT /id="PRO_0000312119"
FT DOMAIN 2517..2637
FT /note="BAH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT REGION 23..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 224..273
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 674..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 721..758
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1023
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1038..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1466..1520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1537..1559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1604..1641
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1746..1781
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1875..1896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2055..2124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2322..2341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2349..2386
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1346..1373
FT /evidence="ECO:0000255"
FT COILED 1437..1486
FT /evidence="ECO:0000255"
FT COMPBIAS 224..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 684..700
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1003
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1042..1062
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1113..1134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1135..1152
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1208..1229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1466..1489
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1875..1894
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2349..2378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 220
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9P281"
FT CONFLICT 122
FT /note="A -> P (in Ref. 2; BAE27797)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="A -> T (in Ref. 1; BAF03198)"
FT /evidence="ECO:0000305"
FT CONFLICT 363
FT /note="S -> N (in Ref. 1; BAF03203)"
FT /evidence="ECO:0000305"
FT CONFLICT 752
FT /note="A -> V (in Ref. 1; BAF03198)"
FT /evidence="ECO:0000305"
FT CONFLICT 921
FT /note="P -> R (in Ref. 1; BAF03198)"
FT /evidence="ECO:0000305"
FT CONFLICT 937
FT /note="L -> LQ (in Ref. 1; BAF03198)"
FT /evidence="ECO:0000305"
FT CONFLICT 1366
FT /note="Q -> QA (in Ref. 2; BAE27888)"
FT /evidence="ECO:0000305"
FT CONFLICT 1826
FT /note="I -> T (in Ref. 1; BAF03198)"
FT /evidence="ECO:0000305"
FT CONFLICT 2237
FT /note="A -> T (in Ref. 2; BAE37691)"
FT /evidence="ECO:0000305"
FT CONFLICT 2352
FT /note="S -> L (in Ref. 2; BAE37691)"
FT /evidence="ECO:0000305"
FT STRAND 2489..2492
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2495..2498
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2505..2514
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2517..2520
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2524..2527
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2538..2547
FT /evidence="ECO:0007829|PDB:6VIL"
FT TURN 2548..2550
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2551..2560
FT /evidence="ECO:0007829|PDB:6VIL"
FT HELIX 2562..2564
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2565..2567
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2577..2588
FT /evidence="ECO:0007829|PDB:6VIL"
FT HELIX 2589..2591
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2592..2599
FT /evidence="ECO:0007829|PDB:6VIL"
FT HELIX 2601..2607
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2616..2626
FT /evidence="ECO:0007829|PDB:6VIL"
FT TURN 2628..2630
FT /evidence="ECO:0007829|PDB:6VIL"
FT STRAND 2633..2635
FT /evidence="ECO:0007829|PDB:6VIL"
SQ SEQUENCE 2643 AA; 282520 MW; 4B4998815D133602 CRC64;
MDGRDFAPPP HLLSERGSLG HRSAAAAARL APAGPAAQPA AHFQPGKYFP SPLPMASHTA
SSRLMGNPPA SSFMGSFLTS SLGSAASAHP SGPTSSPSEP AYRGSHPATS QIWFSHSHEA
PAYPRFSGSL ASTFLPVSHL DHHGNSNVLY GQHRFYGTQK DNFYLRNLPP QPTILPANHN
FPGVPRATPA HPIGSCSRDR IEAASLQKGP KEFDRFLMGK EVGKEKVSKG AEGRERPAVE
EDSGKDRQKL VPPMPAEGPC KEAGPAPRGS CEGRPKHLTS CLLNTKVLNG DMGKASLASC
AGGMLGRPGT GVAAPGRCAK EVAGPVEPGP AFSECLERRQ MLHHAVSYTV PSGLPTGPPP
PLSTGPAGSF PCLQLHAGPD GLCPLQDKVS RDLKASGPTF VPSVGHLADK SRSFQVAEAC
AVAGDGKDRH LDAAMATDHG APYGVSYAHL KAEGKGERRP GGFEAALHPR LKGLEYLSSG
PEAPFPGLPK GGLDKSGYFE LPTSQDCARS NHQDPLGGKA TQACCTLDKV ANKEAPAGPP
VGQKVARIRH QQHLVAPEVE SGGSGAETKR KSVELASLGY SGHHMPPWGV QTGHDTSMAI
IEERKGSAYL DPFGSGLQQA ALLSQELPTP PDEVSAMKNL LKYSNQALVV GQKAPFVGLG
SLKASCVQQE AKFPATKGPG PVERPDCARS REHEAPHGDG EVRQPPVGIA VALARQKDTV
GRPDTAYNTN SGRQGRAAPT FKGAGGPRAS HALDLESEEE RSRACEERLG LPGRELLLQD
NKDLVEFARI HPSSSCPGDL PPHLMMQGGD PAPHPHPAHP HWLPRTRSPS LWMGGHSYGL
GHPALHQNLP PGFPASVPGS MPSVFPLPQD AATQLVILPS EPTPHTTPHT LAEVMDQASL
WPPMYGARGP ASHMQHPGQL PVYSRSQLLR QQELYALQQQ QQQQQQQQQQ QQQQQQQQQQ
QQQQQQQQHR ATQALELQRV AQFQRKPEDR HMELEEAAQE KTPKSTHKPV ALTPMAKGTP
SSATAGLVKL SPCCQSPTLK TPASCPTPPP RPSAPCTLPI CPTGSPGPGS KVPSTMDKSE
EGQRAGTNLT TLEPDLTPGL NPTAGLDLSL PSDVHSSDLQ DPKTMQTTTP GTRPEPPRTF
LPGEPPPCSP RNLEEPGLLS RARDATQDLA NLPPPVEGGL PPGKAEDPSP LEGLQALKFG
DLLEGGGTEA TGQTNSTQGG MQNERTVDQG APQPPLGATP QALEQEAGSP AALDKREGPQ
KVPDVAQLQE EETQLEESGG DSEVDWGTPN HSHPPKALPG LDALVAATVD LGDLPDISLT
DPQTPAASVP LSTAPLPHSS GIHGIALLSE LADLETQRQK SELSMQEDED VLAFNLQHLA
TLATAWSLVE AANLDSPVTS LQAPAADPDR GPRLTPRMQI LQRKDTWAPK TKPVCPLKAA
IDRLDTQEVE MRMQLAELQR RYKEKQRELA RLQRRHDHER EESSRSPARR GPGRPRKRKH
SSSLPALRPG GQLARSDSKK AKAVRASLSL LCAELRGDEP PRKRSKLGKS PYTGLQSVSS
EKVRCKKSCG QAELPSSVAH KVAQLKPKVK SKGLPAGLGA FQRKEAAPGG RIQKKLSRAK
SVTASGAARH PHPDGDSGRE MHKFQAQPAV AVAHEAGSGY DSEDCQALLG TEAAPREPGL
VLHPGSGVAV LGPSPSSVVK MEANQKAKKK KERQGLLGAC RLSSPEGEVK IKRRTVKTKV
GAKLERAPGR RPPGAPGKKK AKGKVKTGLR TEPGTATSRD TLFSPTRTFA CREEGSKLAS
ERLKRATRKS AMLQPVLRRK NGALSIALSA RNAKAILGKS RKLTKVKREA VSKQGQGRAV
SRLLESFAVE DDFEFDEDDT SFSDEEEEEE EAGVQLSAEQ SAALARSCTI HKEDLQDGLP
VLIPKEDSLL YAGSVRTLQP PDIYSIVIEG ERGNRQRIYS LEQLLQEAVL DVQPQSSRYL
PPGTRVCAYW SQKSRCLYPG NVVRGASSDE EDLDSVLVEF DDGDTGHIAV SNIRLLPPDF
KIQCTEPSPA LLVSSSCRRT KKAANEGHPP SEAPTPSLSP KVPDGPETSK TPGKKSGSKD
KAGKVDLLTS GAKSPTGASD HFLGRRGSPL LSWSAVAQTK RKAVAAAAAA AGGKGPGVLQ
NLFQLNGSTK KLRARDTLFP MHSMATPVFG NSFRADSFSS LASSYTPFLG GAGAGLPGGA
HKLLRAKKAE RAEAEKAGRR RAGGEFLVKL DHEGVTSPKN KNCKALLMSD KDFGPKLGRP
LSNPSYAHPA LIGKDKKGRA PVHPLPMGLA LRKYPLPCDS DCPSSYSDED EDGPGLATGV
PSRFLTRLSM SSSSSGSSTS SSSGSVSTSS LCSSDNEDSS YSSDDEDPAL LLQTCLTRPV
PALLAPPEAL RSKGSSPHAH THAQRCFLSR AGVAGAGAGA SPSGSKSKFK RKEALSFSKA
KELSRRQRLP SVENRPKISA FLPARQLWKW SGNPTQRRGM KGKARKLFYK AIVRGKETLR
IGDCAVFLSA GRPNLPYIGR IESLWESWGS NMVVKVKWFY HPEETKLGKR QSDGKNALYQ
SCHEDENDVQ TISHKCQVVG REQYEQMMRG RKYQDQQDLY YLAGTYDPTT GRLVTADGVP
VLC
