BAHD1_MOUSE
ID BAHD1_MOUSE Reviewed; 772 AA.
AC Q497V6; A2AQV1; A6PWW9; B2RUB2; B7ZNH0; Q6ZQ21; Q80VH7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Bromo adjacent homology domain-containing 1 protein;
DE Short=BAH domain-containing protein 1;
GN Name=Bahd1; Synonyms=Gm117, Kiaa0945;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N; TISSUE=Brain, Mammary tumor, and Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Heterochromatin protein that acts as a transcription
CC repressor and has the ability to promote the formation of large
CC heterochromatic domains. May act by recruiting heterochromatin proteins
CC such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by
CC binding to its CpG-rich P3 promoter and recruiting heterochromatin
CC proteins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with CBX5 (HP1 alpha), HDAC5, MBD1 and SP1.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Localizes to
CC heterochromatin and inactive X chromosome. Colocalizes with histone H3
CC trimethylated at 'Lys-27' (H3K27me3) (By similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q497V6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q497V6-2; Sequence=VSP_038527;
CC -!- DOMAIN: The BAH domain is required for localization at H3K27me3.
CC {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98053.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAO77853.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK129243; BAC98053.1; ALT_INIT; mRNA.
DR EMBL; AL845164; CAM19753.1; -; Genomic_DNA.
DR EMBL; AL845164; CAO77853.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH466519; EDL27930.1; -; Genomic_DNA.
DR EMBL; BC047433; AAH47433.1; -; mRNA.
DR EMBL; BC100358; AAI00359.1; -; mRNA.
DR EMBL; BC141046; AAI41047.1; -; mRNA.
DR EMBL; BC145233; AAI45234.1; -; mRNA.
DR CCDS; CCDS38202.1; -. [Q497V6-1]
DR AlphaFoldDB; Q497V6; -.
DR SMR; Q497V6; -.
DR STRING; 10090.ENSMUSP00000043130; -.
DR iPTMnet; Q497V6; -.
DR PhosphoSitePlus; Q497V6; -.
DR jPOST; Q497V6; -.
DR MaxQB; Q497V6; -.
DR PaxDb; Q497V6; -.
DR PRIDE; Q497V6; -.
DR ProteomicsDB; 273595; -. [Q497V6-1]
DR ProteomicsDB; 273596; -. [Q497V6-2]
DR MGI; MGI:2139371; Bahd1.
DR eggNOG; KOG1886; Eukaryota.
DR InParanoid; Q497V6; -.
DR PhylomeDB; Q497V6; -.
DR TreeFam; TF350135; -.
DR PRO; PR:Q497V6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q497V6; protein.
DR GO; GO:0005677; C:chromatin silencing complex; ISS:UniProtKB.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 2.30.30.490; -; 1.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR Pfam; PF01426; BAH; 1.
DR SMART; SM00439; BAH; 1.
DR PROSITE; PS51038; BAH; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Chromatin regulator; Chromosome; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..772
FT /note="Bromo adjacent homology domain-containing 1 protein"
FT /id="PRO_0000287919"
FT DOMAIN 616..771
FT /note="BAH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00370"
FT REGION 1..63
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 131..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 723..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..199
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 532..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 551..581
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 8
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBE0"
FT MOD_RES 101
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBE0"
FT MOD_RES 121
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBE0"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 204
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBE0"
FT MOD_RES 580
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8TBE0"
FT VAR_SEQ 677..679
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_038527"
FT CONFLICT 275
FT /note="D -> N (in Ref. 2; CAM19753)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="T -> A (in Ref. 2; CAM19753)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 772 AA; 83871 MW; 537BD20D92AD563D CRC64;
MTHTRRKSLP MLSSGPTGRG EPLQMEDSNM EQGTEDVEPG MPESPGHLTG RRKNYPLRKR
SLVPEKPKAC KVLLTRLENV AGPRSADEAD ELPPDLPKPP SPTSSSEDAG LVQPRKRRLA
SLNAEALNNL LLEREETSSL AGARRSRGGD PHRSRDRATG SWSFSKKRPR LGDLGEGSRD
LSPELAPDEG ARRDGDPAPK RLASLNAAAF LKLSQERELP LRPSRAQAEA DGRSTEPLAP
RILRPKVNGK NCPKARQGAG SGEATGPPNW QEQPDERWPS APPHGPPTQP SHQAPGKALE
NPLRPNLPLL MGGQAALKPE PGRPGEESPA PKQELHQPSF PAPQLSPLPM PGNPADYSGP
CGGPELTALG SFYLYCGQDG LQCGAYSPCP MLPEGKLSPV AAPNEGLLMA PSSVPSGVPF
QHPPWSAPRY CSSEDTGANG YSICGVLPLS LTHIGTTCGG CPYKMPFTAE GCRSLGQLEF
PLPEAGHPAS PAHPLLGCPV PSVPPAAEPI PHLQTPISEP QTVARACPQS AKPPSGSKSG
LRTGSSCRHT VRSKAARRPS HPKQPRAQRP RPRRRRRRRT NGWVPVGAAC EKAVYVLDEP
EPAIRKSYQA VERHGETIRV RDTVLLKSGP RKTSTPYVAK ISALWENPES GELMMSLLWY
YRPEHLQGGR SPSMHEPLQN EVFASRHQDQ NSVACIEEKC YVLTFAEYCR FCAMAKRRGE
GLPSRKTALV PPSADYSTPP HRTVPEDTDP ELVFLCRHVY DFRHGRILKN PQ
