RS3_ICTPU
ID RS3_ICTPU Reviewed; 245 AA.
AC Q90YS2;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 93.
DE RecName: Full=40S ribosomal protein S3;
DE EC=4.2.99.18 {ECO:0000250|UniProtKB:P23396};
GN Name=rps3;
OS Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC Ictaluridae; Ictalurus.
OX NCBI_TaxID=7998;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12095691; DOI=10.1016/s0378-1119(02)00595-4;
RA Karsi A., Patterson A., Feng J., Liu Z.-J.;
RT "Translational machinery of channel catfish: I. A transcriptomic approach
RT to the analysis of 32 40S ribosomal protein genes and their expression.";
RL Gene 291:177-186(2002).
CC -!- FUNCTION: Involved in translation as a component of the 40S small
CC ribosomal subunit. Has endonuclease activity and plays a role in repair
CC of damaged DNA. Also involved in other processes including regulation
CC of transcription, translation of its cognate mRNA, spindle formation
CC and chromosome movement during mitosis, and apoptosis.
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-
CC deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-
CC dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-
CC 2'-deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-
CC COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695,
CC ChEBI:CHEBI:167181; EC=4.2.99.18;
CC Evidence={ECO:0000250|UniProtKB:P23396};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23396}. Nucleus
CC {ECO:0000250|UniProtKB:P23396}. Nucleus, nucleolus
CC {ECO:0000250|UniProtKB:P23396}. Mitochondrion inner membrane
CC {ECO:0000250|UniProtKB:P23396}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:P23396}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000250|UniProtKB:P23396}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS3 family.
CC {ECO:0000305}.
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DR EMBL; AF402810; AAK95184.1; -; mRNA.
DR RefSeq; NP_001187068.1; NM_001200139.1.
DR AlphaFoldDB; Q90YS2; -.
DR SMR; Q90YS2; -.
DR STRING; 7998.ENSIPUP00000008346; -.
DR PRIDE; Q90YS2; -.
DR GeneID; 100304557; -.
DR KEGG; ipu:100304557; -.
DR CTD; 6188; -.
DR OrthoDB; 1135751at2759; -.
DR Proteomes; UP000221080; Chromosome 4.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0140078; F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR Gene3D; 3.30.1140.32; -; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR004044; KH_dom_type_2.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR001351; Ribosomal_S3_C.
DR InterPro; IPR036419; Ribosomal_S3_C_sf.
DR InterPro; IPR018280; Ribosomal_S3_CS.
DR InterPro; IPR005703; Ribosomal_S3_euk/arc.
DR Pfam; PF07650; KH_2; 1.
DR Pfam; PF00189; Ribosomal_S3_C; 1.
DR SUPFAM; SSF54814; SSF54814; 1.
DR SUPFAM; SSF54821; SSF54821; 1.
DR TIGRFAMs; TIGR01008; uS3_euk_arch; 1.
DR PROSITE; PS50823; KH_TYPE_2; 1.
DR PROSITE; PS00548; RIBOSOMAL_S3; 1.
PE 2: Evidence at transcript level;
KW Apoptosis; Cell cycle; Cell division; Cytoplasm; Cytoskeleton; DNA damage;
KW DNA repair; DNA-binding; Lyase; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; Mitosis; Nucleus; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..245
FT /note="40S ribosomal protein S3"
FT /id="PRO_0000130323"
FT DOMAIN 21..92
FT /note="KH type-2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00118"
FT REGION 215..245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 26890 MW; 01377A16FA932E0E CRC64;
MAVQISKKRK FVSDGIFKAE LNEFLTRELA EDGYSGVEVR VTPTRTEIII LATRTQNVLG
EKGRRIRELT AVVQKRFGFP RGSVELYAEK VATRGLCAIA QAESLRYKLL GGLAVRRACY
GVLRFIMESG AKGCEVVVSG KLRGQRAKSM KFVDGLMIHS GDPVNYYVDT AVRHVLLRQG
VLGIKVKIML PWDPSGKIGP KKPLPDHVSI VEPKEEILPT TPVSEQKGAK PEVPVMPQGA
PVPTA
