BAIG_CLOSV
ID BAIG_CLOSV Reviewed; 477 AA.
AC P32369; Q47873;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Bile acid transporter;
GN Name=baiG;
OS Clostridium scindens (strain JCM 10418 / VPI 12708).
OC Bacteria; Firmicutes; Clostridia; Eubacteriales; Lachnospiraceae.
OX NCBI_TaxID=29347;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Mallonee D.H., Hylemon P.B.;
RL Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 266-477.
RX PubMed=8491719; DOI=10.1128/jb.175.10.3002-3012.1993;
RA Franklund C.V., Baron S.F., Hylemon P.B.;
RT "Characterization of the baiH gene encoding a bile acid-inducible
RT NADH:flavin oxidoreductase from Eubacterium sp. strain VPI 12708.";
RL J. Bacteriol. 175:3002-3012(1993).
CC -!- PATHWAY: Lipid metabolism; bile acid degradation.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; U57489; AAC45416.1; -; Genomic_DNA.
DR PIR; A36912; A36912.
DR AlphaFoldDB; P32369; -.
DR SMR; P32369; -.
DR TCDB; 2.A.1.3.13; the major facilitator superfamily (mfs).
DR UniPathway; UPA00279; -.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 2.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Bile acid catabolism; Cell membrane; Lipid degradation; Lipid metabolism;
KW Membrane; Steroid metabolism; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..477
FT /note="Bile acid transporter"
FT /id="PRO_0000173314"
FT TRANSMEM 13..33
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 83..103
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 139..159
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 359..379
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..401
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 406..426
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT CONFLICT 442
FT /note="A -> T (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 477 AA; 49938 MW; 523A906B3187BDF9 CRC64;
MSTVANPNYK KGFVPFAIAA LLVSLIGGFT AVLGPAFVAD QGIDYNNTTW ISLALAMSSA
ACAPILGKLG DVLGRRTTLL LGIVIFAAGN VLTAVATSLI FMLAARFIVG IGTAAISPIV
MAYIVTEYPQ EETGKAFGLY MLISSGAVVV GPTCGGLIMN AAGWRVMMWV CVALCVVVFL
ICTFSIKKTA FEKKSMAGFD KPGAALVVVF FSLFLCIPSF GQNIGWSSTA FIAAAAVALV
ALFILVMVEK KAKSPIMNGK FMARKEFVLP VLILFLTQGL MMANMTNVIV FVRYTQPDNV
IISSFAISIM YIGMSLGSVI IGPVADKKEP KTVLTFSLVL TAIGCALMYL FKADSSVAIF
AASLGILGFG LGGNATIFMK VALSGLSSEV AGSGTGTYGL FRDISAPFGV AVFVPMFANG
VTANIAKYAS GGMEEGAATV KAAISSIQTL TLVELGCIVV GIILVRMLPR IYQKKEA
