ABCAA_DICDI
ID ABCAA_DICDI Reviewed; 887 AA.
AC Q54R52; Q8T6I7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=ABC transporter A family member 10;
DE AltName: Full=ABC transporter ABCA.10;
GN Name=abcA10; ORFNames=DDB_G0283387;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND NOMENCLATURE.
RC STRAIN=AX4;
RX PubMed=12456012; DOI=10.1128/ec.1.4.643-652.2002;
RA Anjard C., Loomis W.F.;
RT "Evolutionary analyses of ABC transporters of Dictyostelium discoideum.";
RL Eukaryot. Cell 1:643-652(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC {ECO:0000305}.
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DR EMBL; AF465312; AAL85303.1; -; Genomic_DNA.
DR EMBL; AAFI02000055; EAL65678.1; -; Genomic_DNA.
DR RefSeq; XP_639039.1; XM_633947.1.
DR AlphaFoldDB; Q54R52; -.
DR SMR; Q54R52; -.
DR STRING; 44689.DDB0191529; -.
DR PaxDb; Q54R52; -.
DR EnsemblProtists; EAL65678; EAL65678; DDB_G0283387.
DR GeneID; 8624064; -.
DR KEGG; ddi:DDB_G0283387; -.
DR dictyBase; DDB_G0283387; abcA10.
DR eggNOG; KOG0059; Eukaryota.
DR HOGENOM; CLU_315910_0_0_1; -.
DR InParanoid; Q54R52; -.
DR OMA; AWYAIEV; -.
DR PhylomeDB; Q54R52; -.
DR Reactome; R-DDI-1369062; ABC transporters in lipid homeostasis.
DR Reactome; R-DDI-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-DDI-382556; ABC-family proteins mediated transport.
DR Reactome; R-DDI-6798695; Neutrophil degranulation.
DR Reactome; R-DDI-8963896; HDL assembly.
DR PRO; PR:Q54R52; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR GO; GO:0031288; P:sorocarp morphogenesis; IMP:dictyBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 4.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..887
FT /note="ABC transporter A family member 10"
FT /id="PRO_0000363842"
FT TRANSMEM 38..58
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 245..265
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 376..396
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 481..728
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 443..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 443..467
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 519..526
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CONFLICT 636..637
FT /note="RR -> KK (in Ref. 1; AAL85303)"
FT /evidence="ECO:0000305"
FT CONFLICT 641
FT /note="A -> P (in Ref. 1; AAL85303)"
FT /evidence="ECO:0000305"
FT CONFLICT 689
FT /note="D -> N (in Ref. 1; AAL85303)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 887 AA; 99603 MW; 279A4D56D06A86EF CRC64;
MTNNCKITFK NQLKALLGKA ILLKKKKRKE TITEFTQGIQ YIIVLVILHY TIPNVITLNT
YSPVGLGYPT SGFPLCYVSN VPFNQTSNLH LLLNSTQLPI SQIVQFPNEQ SLIDSYKSNP
QSITYGISFN NIDYQNNILD YNILLNSTFQ NTQLISIVQN LFLSTFAEIK GITTTTTTTL
SSIEEFPNLT SSVSVSSYLY VIYLPLLFLF SLQQLLVTSV TERKNHIKEV MKVMGLKELV
YWVTIIIVQT ITNVINILLV MVVLYFTKTL TTSLNPVMLF LQFLLYSFSM VAIGIILSNL
VDTPKTASAI SSFLLLILVG VSCFYQFYLK SKTSSSWLRS ILFLFSPCAF GEFLYKMGND
QQMMLTTNWS DPQVKISFLF LIIDIFLYFT IAWYITELYK DNTDENSITK SFTFFLSLSY
WKSIFNLRSS SSSSSLPLLN NNNNCNNNNT SPSSSSSSQS SPLNKPLLSG DSDDDENDIG
IRLVNLKKTY KNPITKETVN AVNDVSYTIK KGTILALLGQ NGSGKTSTIG MLNGMRSPSS
GDAFINGLSI KYDMDKIREN GIGLCHQSNI LYDEFTCAEH IALYSRLKGL FVDGGGANGD
NKRIMMDNFI MESLGEVNLV DKKDTQSIKL SGGMKRRLCL AISLIGNPSI LLLDEPSSGL
DSLSQHMICE LLQRKKPNKT IILTTHNLDS AELLGDKICI MTSGKVKAMG SSLELKNQFN
LGYILTIVYD KSLSLLQPPN INQQFESFFF NKFNDSTQSK QNLKNIQSFY NIFNNNNNEN
NSNNSDGSSS SSDSSSSKDV LLNIKNNNNN NNNNEERGFS SGQRDLELEY SLTHQSTDVI
TEFLEELESR QDEFKIKRIS MSMTTLDEVF LKVSEEETIN KNKQPTS
