ID   BALF1_EBVB9             Reviewed;         220 AA.
AC   P0CK58; P03229; Q777A6;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   23-FEB-2022, entry version 38.
DE   RecName: Full=Apoptosis regulator BALF1;
GN   ORFNames=BALF1;
OS   Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10377;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=6087149; DOI=10.1038/310207a0;
RA   Baer R., Bankier A.T., Biggin M.D., Deininger P.L., Farrell P.J.,
RA   Gibson T.J., Hatfull G., Hudson G.S., Satchwell S.C., Seguin C.,
RA   Tuffnell P.S., Barrell B.G.;
RT   "DNA sequence and expression of the B95-8 Epstein-Barr virus genome.";
RL   Nature 310:207-211(1984).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA], FUNCTION, INTERACTION WITH BHRF1, AND
RP   SUBCELLULAR LOCATION.
RC   STRAIN=G54, G64, Mutu, and NPC-7;
RX   PubMed=11836425; DOI=10.1128/jvi.76.5.2469-2479.2002;
RA   Bellows D.S., Howell M., Pearson C., Hazlewood S.A., Hardwick J.M.;
RT   "Epstein-Barr virus BALF1 is a BCL-2-like antagonist of the herpesvirus
RT   antiapoptotic BCL-2 proteins.";
RL   J. Virol. 76:2469-2479(2002).
RN   [3]
RP   FUNCTION, AND INTERACTION WITH HOST BAX AND BAK1.
RX   PubMed=10233985; DOI=10.1128/jvi.73.6.5181-5185.1999;
RA   Marshall W.L., Yim C., Gustafson E., Graf T., Sage D.R., Hanify K.,
RA   Williams L., Fingeroth J., Finberg R.W.;
RT   "Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that
RT   inhibits apoptosis and associates with Bax and Bak.";
RL   J. Virol. 73:5181-5185(1999).
RN   [4]
RP   FUNCTION.
RX   PubMed=16087121; DOI=10.1016/j.jcv.2004.12.016;
RA   Cabras G., Decaussin G., Zeng Y., Djennaoui D., Melouli H., Broully P.,
RA   Bouguermouh A.M., Ooka T.;
RT   "Epstein-Barr virus encoded BALF1 gene is transcribed in Burkitt's lymphoma
RT   cell lines and in nasopharyngeal carcinoma's biopsies.";
RL   J. Clin. Virol. 34:26-34(2005).
CC   -!- FUNCTION: Modulates the antiapoptotic activity of the viral protein
CC       BHRF1. May also play an active part in oncogenesis in Burkitt's
CC       lymphomy and nasopharyngeal carcinoma. {ECO:0000269|PubMed:10233985,
CC       ECO:0000269|PubMed:11836425, ECO:0000269|PubMed:16087121}.
CC   -!- SUBUNIT: Interacts with BHRF1; this interaction modulates BHRF1
CC       activity. Interacts with host BAX and BAK1.
CC       {ECO:0000269|PubMed:10233985, ECO:0000269|PubMed:11836425}.
CC   -!- INTERACTION:
CC       P0CK58; Q1HVC7: BVRF2; Xeno; NbExp=2; IntAct=EBI-2621293, EBI-2621352;
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:11836425}.
CC   -!- SIMILARITY: Belongs to the Epstein-Barr virus BALF1 family.
CC       {ECO:0000305}.
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DR   EMBL; V01555; CAA24810.1; -; Genomic_DNA.
DR   EMBL; AJ507799; CAD53468.1; -; Genomic_DNA.
DR   EMBL; AF401274; AAK95616.1; -; Genomic_DNA.
DR   EMBL; AF401276; AAK95618.1; -; Genomic_DNA.
DR   EMBL; AF401277; AAK95619.1; -; Genomic_DNA.
DR   EMBL; AF401278; AAK95620.1; -; Genomic_DNA.
DR   PIR; C43045; QQBE49.
DR   RefSeq; YP_401718.2; NC_007605.1.
DR   SMR; P0CK58; -.
DR   IntAct; P0CK58; 136.
DR   MINT; P0CK58; -.
DR   PRIDE; P0CK58; -.
DR   DNASU; 3783677; -.
DR   GeneID; 3783677; -.
DR   KEGG; vg:3783677; -.
DR   Proteomes; UP000153037; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0039526; P:modulation by virus of host apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IDA:CACAO.
DR   InterPro; IPR010677; HHV-4_BALF1.
DR   Pfam; PF06861; BALF1; 1.
PE   1: Evidence at protein level;
KW   Apoptosis; Early protein; Host cytoplasm; Host-virus interaction;
KW   Modulation of host cell apoptosis by virus; Oncogene; Reference proteome.
FT   CHAIN           1..220
FT                   /note="Apoptosis regulator BALF1"
FT                   /id="PRO_0000116271"
SQ   SEQUENCE   220 AA;  25148 MW;  F0292CEA80626C96 CRC64;
     MNLAIALDSP HPGLASYTIL PRPFYHISLK PVSWPDETMR PAKSTDSVFV RTPVEAWVAP
     SPPDDKVAES SYLMFRAMYA VFTRDEKDLP LPALVLCRLI KASLRKDRKL YAELACRTAD
     IGGKDTHVRL IISVLRAVYN DHYDYWSRLR VVLCYTVVFA VRNYLDDHKS AAFVLGAIAH
     YLALYRRLWF ARLGGMPRSL RRQFPVTWAL ASLTDFLKSL