ID   BALF1_EBVG              Reviewed;         220 AA.
AC   P0CK59; P03229; Q777A6;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2012, sequence version 1.
DT   02-JUN-2021, entry version 23.
DE   RecName: Full=Apoptosis regulator BALF1;
GN   ORFNames=BALF1;
OS   Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus.
OX   NCBI_TaxID=10376;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16306603; DOI=10.1128/jvi.79.24.15323-15330.2005;
RA   Zeng M.-S., Li D.-J., Liu Q.-L., Song L.-B., Li M.-Z., Zhang R.-H.,
RA   Yu X.-J., Wang H.-M., Ernberg I., Zeng Y.-X.;
RT   "Genomic sequence analysis of Epstein-Barr virus strain GD1 from a
RT   nasopharyngeal carcinoma patient.";
RL   J. Virol. 79:15323-15330(2005).
CC   -!- FUNCTION: May play a role in host B-cell survival by preventing host
CC       apoptosis. The survival of infected B-cells is a key step to induce
CC       host cell differentiation into memory cells, thereby assuring long term
CC       infection of the organism. May also play an active part in oncogenesis
CC       in Burkitt's lymphomy and nasopharyngeal carcinoma (By similarity).
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the Epstein-Barr virus BALF1 family.
CC       {ECO:0000305}.
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DR   EMBL; AY961628; AAY41157.1; -; Genomic_DNA.
DR   RefSeq; YP_401718.2; NC_007605.1.
DR   SMR; P0CK59; -.
DR   DNASU; 3783677; -.
DR   GeneID; 3783677; -.
DR   KEGG; vg:3783677; -.
DR   Proteomes; UP000007641; Genome.
DR   InterPro; IPR010677; HHV-4_BALF1.
DR   Pfam; PF06861; BALF1; 1.
PE   3: Inferred from homology;
KW   Apoptosis; Early protein; Oncogene.
FT   CHAIN           1..220
FT                   /note="Apoptosis regulator BALF1"
FT                   /id="PRO_0000415974"
SQ   SEQUENCE   220 AA;  25148 MW;  F0292CEA80626C96 CRC64;
     MNLAIALDSP HPGLASYTIL PRPFYHISLK PVSWPDETMR PAKSTDSVFV RTPVEAWVAP
     SPPDDKVAES SYLMFRAMYA VFTRDEKDLP LPALVLCRLI KASLRKDRKL YAELACRTAD
     IGGKDTHVRL IISVLRAVYN DHYDYWSRLR VVLCYTVVFA VRNYLDDHKS AAFVLGAIAH
     YLALYRRLWF ARLGGMPRSL RRQFPVTWAL ASLTDFLKSL