BAMA1_HAEIF
ID BAMA1_HAEIF Reviewed; 797 AA.
AC P46024;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Outer membrane protein assembly factor BamA {ECO:0000255|HAMAP-Rule:MF_01430};
DE AltName: Full=80 kDa D15 antigen;
DE Short=D-15-Ag;
DE AltName: Full=Outer membrane protein D15;
DE AltName: Full=Protective surface antigen D15;
DE Flags: Precursor;
GN Name=bamA {ECO:0000255|HAMAP-Rule:MF_01430};
OS Haemophilus influenzae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Haemophilus.
OX NCBI_TaxID=727;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Serotype B;
RX PubMed=7737523; DOI=10.1016/0378-1119(95)00049-c;
RA Flack F.S., Loosmore S., Chong P., Thomas W.R.;
RT "The sequencing of the 80-kDa D15 protective surface antigen of Haemophilus
RT influenzae.";
RL Gene 156:97-99(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Eagan / Serotype B, and Minna / Serotype B;
RX PubMed=9284140; DOI=10.1128/iai.65.9.3701-3707.1997;
RA Loosmore S.M., Yang Y.P., Coleman D.C., Shortreed J.M., England D.M.,
RA Klein M.H.;
RT "Outer membrane protein D15 is conserved among Haemophilus influenzae
RT species and may represent a universal protective antigen against invasive
RT disease.";
RL Infect. Immun. 65:3701-3707(1997).
CC -!- FUNCTION: Part of the outer membrane protein assembly complex, which is
CC involved in assembly and insertion of beta-barrel proteins into the
CC outer membrane. {ECO:0000255|HAMAP-Rule:MF_01430}.
CC -!- SUBUNIT: Part of the Bam complex. {ECO:0000255|HAMAP-Rule:MF_01430}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01430}.
CC -!- SIMILARITY: Belongs to the BamA family. {ECO:0000255|HAMAP-
CC Rule:MF_01430}.
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DR EMBL; U13961; AAA85645.1; -; Genomic_DNA.
DR EMBL; U60832; AAB61974.1; -; Genomic_DNA.
DR EMBL; U60833; AAB61976.1; -; Genomic_DNA.
DR PIR; JC4078; JC4078.
DR RefSeq; WP_015701933.1; NZ_VOFX01000001.1.
DR PDB; 6IZS; X-ray; 2.03 A; A=260-344.
DR PDB; 6IZT; X-ray; 2.03 A; A/B=173-418.
DR PDBsum; 6IZS; -.
DR PDBsum; 6IZT; -.
DR AlphaFoldDB; P46024; -.
DR SMR; P46024; -.
DR TCDB; 1.B.33.1.2; the outer membrane protein insertion porin (bam complex) (ompip) family.
DR PRIDE; P46024; -.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01430; OM_assembly_BamA; 1.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR010827; BamA/TamA_POTRA.
DR InterPro; IPR039910; D15-like.
DR InterPro; IPR023707; OM_assembly_BamA.
DR InterPro; IPR034746; POTRA.
DR PANTHER; PTHR12815; PTHR12815; 1.
DR PANTHER; PTHR12815:SF23; PTHR12815:SF23; 1.
DR Pfam; PF01103; Omp85; 1.
DR Pfam; PF07244; POTRA; 4.
DR PIRSF; PIRSF006076; OM_assembly_OMP85; 1.
DR TIGRFAMs; TIGR03303; OM_YaeT; 1.
DR PROSITE; PS51779; POTRA; 5.
PE 1: Evidence at protein level;
KW 3D-structure; Cell outer membrane; Membrane; Repeat; Signal; Transmembrane;
KW Transmembrane beta strand.
FT SIGNAL 1..19
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01430"
FT CHAIN 20..797
FT /note="Outer membrane protein assembly factor BamA"
FT /id="PRO_0000033467"
FT DOMAIN 22..89
FT /note="POTRA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 90..170
FT /note="POTRA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 173..259
FT /note="POTRA 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 262..341
FT /note="POTRA 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 344..418
FT /note="POTRA 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT STRAND 173..182
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 184..186
FT /evidence="ECO:0007829|PDB:6IZT"
FT HELIX 188..193
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 201..206
FT /evidence="ECO:0007829|PDB:6IZT"
FT HELIX 212..228
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 235..242
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 245..248
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 250..257
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 263..272
FT /evidence="ECO:0007829|PDB:6IZT"
FT HELIX 277..280
FT /evidence="ECO:0007829|PDB:6IZT"
FT HELIX 281..286
FT /evidence="ECO:0007829|PDB:6IZT"
FT HELIX 295..310
FT /evidence="ECO:0007829|PDB:6IZT"
FT TURN 311..313
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 318..326
FT /evidence="ECO:0007829|PDB:6IZT"
FT TURN 327..330
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 331..339
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 345..353
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 355..357
FT /evidence="ECO:0007829|PDB:6IZT"
FT HELIX 359..365
FT /evidence="ECO:0007829|PDB:6IZT"
FT HELIX 376..387
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 393..401
FT /evidence="ECO:0007829|PDB:6IZT"
FT STRAND 406..416
FT /evidence="ECO:0007829|PDB:6IZT"
SQ SEQUENCE 797 AA; 87676 MW; 2F93DE538696AF1B CRC64;
MKKLLIASLL FGTTTTVFAA PFVAKDIRVD GVQGDLEQQI RASLPVRAGQ RVTDNDVANI
VRSLFVSGRF DDVKAHQEGD VLVVSVVAKS IISDVKIKGN SVIPTEALKQ NLDANGFKVG
DVLIREKLNE FAKSVKEHYA SVGRYNATVE PIVNTLPNNR AEILIQINED DKAKLASLTF
KGNESVSSST LQEQMELQPD SWWKLWGNKF EGAQFEKDLQ SIRDYYLNNG YAKAQITKTD
VQLNDEKTKV NVTIDVNEGL QYDLRSARII GNLGGMSAEL EPLLSALHLN DTFRRSDIAD
VENAIKAKLG ERGYGSATVN SVPDFDDANK TLAITLVVDA GRRLTVRQLR FEGNTVSADS
TLRQEMRQQE GTWYNSQLVE LGKIRLDRTG FFETVENRID PINGSNDEVD VVYKVKERNT
GSINFGIGYG TESGISYQAS VKQDNFLGTG AAVSIAGTKN DYGTSVNLGY TEPYFTKDGV
SLGGNVFFEN YDNSKSDTSS NYKRTTYGSN VTLGFPVNEN NSYYVGLGHT YNKISNFALE
YNRNLYIQSM KFKGNGIKTN DFDFSFGWNY NSLNRGYFPT KGVKASLGGR VTIPGSDNKY
YKLSADVQGF YPLDRDHLWV VSAKASAGYA NGFGNKRLPF YQTYTAGGIG SLRGFAYGSI
GPNAIYAEYG NGSGTGTFKK ISSDVIGGNA IATASAELIV PTPFVSDKSQ NTVRTSLFVD
AASVWNTKWK SDKNGLESDV LKRLPDYGKS SRIRASTGVG FQWQSPIGPL VFSYAKPIKK
YENDDVEQFQ FSIGGSF
