RS3_THET2
ID RS3_THET2 Reviewed; 239 AA.
AC P62663;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=30S ribosomal protein S3;
GN Name=rpsC; Synonyms=rps3; OrderedLocusNames=TT_C1322;
OS Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27).
OC Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus.
OX NCBI_TaxID=262724;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11296217; DOI=10.1093/emboj/20.8.1829;
RA Pioletti M., Schluenzen F., Harms J., Zarivach R., Gluehmann M., Avila H.,
RA Bashan A., Bartels H., Auerbach T., Jacobi C., Hartsch T., Yonath A.,
RA Franceschi F.;
RT "Crystal structures of complexes of the small ribosomal subunit with
RT tetracycline, edeine and IF3.";
RL EMBO J. 20:1829-1839(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-163 / DSM 7039 / HB27;
RX PubMed=15064768; DOI=10.1038/nbt956;
RA Henne A., Brueggemann H., Raasch C., Wiezer A., Hartsch T., Liesegang H.,
RA Johann A., Lienard T., Gohl O., Martinez-Arias R., Jacobi C.,
RA Starkuviene V., Schlenczeck S., Dencker S., Huber R., Klenk H.-P.,
RA Kramer W., Merkl R., Gottschalk G., Fritz H.-J.;
RT "The genome sequence of the extreme thermophile Thermus thermophilus.";
RL Nat. Biotechnol. 22:547-553(2004).
CC -!- FUNCTION: Binds the lower part of the 30S subunit head. Binds mRNA in
CC the 70S ribosome, positioning it for translation (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit. Forms a tight complex with
CC proteins S10 and S14 (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS3 family.
CC {ECO:0000305}.
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DR EMBL; AJ409330; CAC35062.1; -; Genomic_DNA.
DR EMBL; AE017221; AAS81664.1; -; Genomic_DNA.
DR RefSeq; WP_008633418.1; NC_005835.1.
DR PDB; 4KVB; X-ray; 4.20 A; C=1-239.
DR PDB; 4V4I; X-ray; 3.71 A; d=1-239.
DR PDB; 4V4J; X-ray; 3.83 A; d=1-239.
DR PDB; 4V63; X-ray; 3.21 A; AC/CC=1-239.
DR PDB; 4V67; X-ray; 3.00 A; AC/CC=1-239.
DR PDB; 4V7P; X-ray; 3.62 A; AC/DC=2-207.
DR PDB; 4V83; X-ray; 3.50 A; AC/CC=2-207.
DR PDB; 4V84; X-ray; 3.40 A; AC/CC=2-207.
DR PDB; 4V9J; X-ray; 3.86 A; AC/CC=2-208.
DR PDB; 4V9K; X-ray; 3.50 A; AC/CC=2-208.
DR PDB; 4V9L; X-ray; 3.50 A; AC/CC=2-208.
DR PDB; 4V9M; X-ray; 4.00 A; AC/CC=2-208.
DR PDB; 4V9N; X-ray; 3.40 A; AC/CC=2-207.
DR PDB; 4V9Q; X-ray; 3.40 A; BC/DC=2-207.
DR PDB; 4W29; X-ray; 3.80 A; AC/CC=2-208.
DR PDB; 4XEJ; X-ray; 3.80 A; AS03/BS03=2-207.
DR PDB; 5J4D; X-ray; 3.10 A; LA/QC=1-239.
DR PDBsum; 4KVB; -.
DR PDBsum; 4V4I; -.
DR PDBsum; 4V4J; -.
DR PDBsum; 4V63; -.
DR PDBsum; 4V67; -.
DR PDBsum; 4V7P; -.
DR PDBsum; 4V83; -.
DR PDBsum; 4V84; -.
DR PDBsum; 4V9J; -.
DR PDBsum; 4V9K; -.
DR PDBsum; 4V9L; -.
DR PDBsum; 4V9M; -.
DR PDBsum; 4V9N; -.
DR PDBsum; 4V9Q; -.
DR PDBsum; 4W29; -.
DR PDBsum; 4XEJ; -.
DR PDBsum; 5J4D; -.
DR AlphaFoldDB; P62663; -.
DR SMR; P62663; -.
DR IntAct; P62663; 4.
DR STRING; 262724.TT_C1322; -.
DR DrugBank; DB08185; 2-METHYLTHIO-N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE.
DR EnsemblBacteria; AAS81664; AAS81664; TT_C1322.
DR GeneID; 3168725; -.
DR KEGG; tth:TT_C1322; -.
DR eggNOG; COG0092; Bacteria.
DR HOGENOM; CLU_058591_0_2_0; -.
DR OMA; KTNPIGN; -.
DR OrthoDB; 1132353at2; -.
DR EvolutionaryTrace; P62663; -.
DR Proteomes; UP000000592; Chromosome.
DR GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR GO; GO:0003729; F:mRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1140.32; -; 1.
DR Gene3D; 3.30.300.20; -; 1.
DR HAMAP; MF_01309_B; Ribosomal_S3_B; 1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR015946; KH_dom-like_a/b.
DR InterPro; IPR004044; KH_dom_type_2.
DR InterPro; IPR009019; KH_sf_prok-type.
DR InterPro; IPR005704; Ribosomal_S3_bac-typ.
DR InterPro; IPR001351; Ribosomal_S3_C.
DR InterPro; IPR036419; Ribosomal_S3_C_sf.
DR InterPro; IPR018280; Ribosomal_S3_CS.
DR Pfam; PF07650; KH_2; 1.
DR Pfam; PF00189; Ribosomal_S3_C; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54814; SSF54814; 1.
DR SUPFAM; SSF54821; SSF54821; 1.
DR TIGRFAMs; TIGR01009; rpsC_bact; 1.
DR PROSITE; PS50823; KH_TYPE_2; 1.
DR PROSITE; PS00548; RIBOSOMAL_S3; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..239
FT /note="30S ribosomal protein S3"
FT /id="PRO_0000130222"
FT DOMAIN 40..108
FT /note="KH type-2"
FT REGION 212..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..239
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT HELIX 7..10
FT /evidence="ECO:0007829|PDB:4V67"
FT TURN 11..15
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 19..22
FT /evidence="ECO:0007829|PDB:4V63"
FT TURN 26..28
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 29..45
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 48..50
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 52..55
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 57..65
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 68..71
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 74..77
FT /evidence="ECO:0007829|PDB:4V67"
FT TURN 78..81
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 83..92
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 95..98
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 101..105
FT /evidence="ECO:0007829|PDB:4V9L"
FT HELIX 109..111
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 113..125
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 130..143
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 147..155
FT /evidence="ECO:0007829|PDB:4V67"
FT HELIX 157..159
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 164..166
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 169..171
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 175..178
FT /evidence="ECO:0007829|PDB:4V9L"
FT STRAND 182..187
FT /evidence="ECO:0007829|PDB:4V67"
FT STRAND 196..203
FT /evidence="ECO:0007829|PDB:4V67"
SQ SEQUENCE 239 AA; 26701 MW; AD585A1D53AC7F04 CRC64;
MGNKIHPIGF RLGITRDWES RWYAGKKQYR HLLLEDQRIR GLLEKELYSA GLARVDIERA
ADNVAVTVHV AKPGVVIGRG GERIRVLREE LAKLTGKNVA LNVQEVQNPN LSAPLVAQRV
AEQIERRFAV RRAIKQAVQR VMESGAKGAK VIVSGRIGGA EQARTEWAAQ GRVPLHTLRA
NIDYGFALAR TTYGVLGVKA YIFLGEVIGG QKPKARPELP KAEERPRRRR PAVRVKKEE
