ID   BAMA2_HAEIF             Reviewed;         793 AA.
AC   O32629;
DT   08-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Outer membrane protein assembly factor BamA {ECO:0000255|HAMAP-Rule:MF_01430};
DE   AltName: Full=80 kDa D15 antigen;
DE            Short=D-15-Ag;
DE   AltName: Full=Outer membrane protein D15;
DE   AltName: Full=Protective surface antigen D15;
DE   Flags: Precursor;
GN   Name=bamA {ECO:0000255|HAMAP-Rule:MF_01430};
OS   Haemophilus influenzae.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=727;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=PAK 12085;
RX   PubMed=9284140; DOI=10.1128/iai.65.9.3701-3707.1997;
RA   Loosmore S.M., Yang Y.P., Coleman D.C., Shortreed J.M., England D.M.,
RA   Klein M.H.;
RT   "Outer membrane protein D15 is conserved among Haemophilus influenzae
RT   species and may represent a universal protective antigen against invasive
RT   disease.";
RL   Infect. Immun. 65:3701-3707(1997).
CC   -!- FUNCTION: Part of the outer membrane protein assembly complex, which is
CC       involved in assembly and insertion of beta-barrel proteins into the
CC       outer membrane. {ECO:0000255|HAMAP-Rule:MF_01430}.
CC   -!- SUBUNIT: Part of the Bam complex. {ECO:0000255|HAMAP-Rule:MF_01430}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01430}.
CC   -!- SIMILARITY: Belongs to the BamA family. {ECO:0000255|HAMAP-
CC       Rule:MF_01430}.
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DR   EMBL; U60834; AAB61977.1; -; Genomic_DNA.
DR   AlphaFoldDB; O32629; -.
DR   SMR; O32629; -.
DR   PRIDE; O32629; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0051205; P:protein insertion into membrane; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01430; OM_assembly_BamA; 1.
DR   InterPro; IPR000184; Bac_surfAg_D15.
DR   InterPro; IPR010827; BamA/TamA_POTRA.
DR   InterPro; IPR039910; D15-like.
DR   InterPro; IPR023707; OM_assembly_BamA.
DR   InterPro; IPR034746; POTRA.
DR   PANTHER; PTHR12815; PTHR12815; 1.
DR   PANTHER; PTHR12815:SF23; PTHR12815:SF23; 1.
DR   Pfam; PF01103; Omp85; 1.
DR   Pfam; PF07244; POTRA; 4.
DR   PIRSF; PIRSF006076; OM_assembly_OMP85; 1.
DR   TIGRFAMs; TIGR03303; OM_YaeT; 1.
DR   PROSITE; PS51779; POTRA; 5.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Repeat; Signal; Transmembrane;
KW   Transmembrane beta strand.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01430"
FT   CHAIN           20..793
FT                   /note="Outer membrane protein assembly factor BamA"
FT                   /id="PRO_0000033469"
FT   DOMAIN          22..89
FT                   /note="POTRA 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT   DOMAIN          90..170
FT                   /note="POTRA 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT   DOMAIN          173..259
FT                   /note="POTRA 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT   DOMAIN          262..341
FT                   /note="POTRA 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT   DOMAIN          344..418
FT                   /note="POTRA 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
SQ   SEQUENCE   793 AA;  87512 MW;  51BFDB2036801A14 CRC64;
     MKKLLIASLL FGTTTTVFAA PFVAKDIRVD GVQGDLEQQI RASLPVRAGQ RVTDNDVANI
     VRSLFVSGRF DDVKAHQEGD VLVVSVVAKS IISDVKIKGN SVIPTEALKQ NLDANGFKVG
     DVLIREKLNE FAKSVKEHYA SVGRYNATVE PIVNTLPNNR AEILIQINED DKAKLASLTF
     KGNESVSSST LQEQMELQPD SWWKLWGNKF EGAQFEKDLQ AIRDYYLNNG YAKAQITKTD
     VQLNDEKTKV NVTIDVNEGL QYDLRSARII GNLGGMSAEL EPLLSALHLN DTFRRSDIAD
     VENAIKAKLG ERGYGNTTVN SVPDFDDANK TLAITFVVDA GRRLTVRQLR FEGNTVSADS
     TLRQEMRQQE GTWYNSQLVE LGKIRLDRTG FFETVENRID PINGSNDEVD VVYKVKERNT
     GSINFGIGYG TESGISYQTS IKQDNFLGTG AAVSIAGTKN DYGTSVNLGY TEPYFTKDGV
     SLGGNIFFEN YDNSKSDTSS NYKRTTYGSN VTLGFPVNEN NSYYVGLGHT YNKISNFALE
     YNRNLYIQSM KFKGNGIKTN DFDFSFGWNY NSLNRGYFPT KGVKASLGGR VTIPGSDNKY
     YKLSADVQGF YPLDRDHRWV VSAKASAGYA NGFGNKRLPF YQTYTAGGIG SLRGFAYGSI
     GPNAIYAEHG NGTFNKISSD VIGGNAITTA SAELIVPTPF VSDKSQNTVR TSLFVDAASV
     WNTKWKSDKN GLESKVLKDL PDYGKSSRIR ASTGVGFQWQ SPIGPLVFSY AKPIKKYEND
     DVEQFQFSIG GSF