ID   RS4X_MONDO              Reviewed;         263 AA.
AC   O62738;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 122.
DE   RecName: Full=40S ribosomal protein S4, X isoform;
GN   Name=RPS4X;
OS   Monodelphis domestica (Gray short-tailed opossum).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Didelphimorphia; Didelphidae; Monodelphis.
OX   NCBI_TaxID=13616;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Spleen;
RX   PubMed=9723615; DOI=10.1038/29522;
RA   Jegalian K.G., Page D.C.;
RT   "A proposed path by which genes common to mammalian X and Y chromosomes
RT   evolve to become X inactivated.";
RL   Nature 394:776-780(1998).
CC   -!- SUBUNIT: Identified in a IGF2BP1-dependent mRNP granule complex
CC       containing untranslated mRNAs. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localized in
CC       cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC       {ECO:0000305}.
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DR   EMBL; AF051136; AAC32105.1; -; mRNA.
DR   RefSeq; NP_001028159.1; NM_001032987.1.
DR   AlphaFoldDB; O62738; -.
DR   SMR; O62738; -.
DR   STRING; 13616.ENSMODP00000013861; -.
DR   PRIDE; O62738; -.
DR   Ensembl; ENSMODT00000053049; ENSMODP00000058525; ENSMODG00000011070.
DR   GeneID; 554195; -.
DR   KEGG; mdo:554195; -.
DR   CTD; 6191; -.
DR   eggNOG; KOG0378; Eukaryota.
DR   GeneTree; ENSGT00390000005569; -.
DR   HOGENOM; CLU_060400_1_0_1; -.
DR   InParanoid; O62738; -.
DR   OMA; PAGFIMD; -.
DR   OrthoDB; 1065966at2759; -.
DR   TreeFam; TF300612; -.
DR   Proteomes; UP000002280; Chromosome X.
DR   Bgee; ENSMODG00000011070; Expressed in skeleton of lower jaw and 19 other tissues.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR   GO; GO:0005840; C:ribosome; ISS:UniProtKB.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   CDD; cd06087; KOW_RPS4; 1.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.740; -; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   HAMAP; MF_00485; Ribosomal_S4e; 1.
DR   InterPro; IPR032277; 40S_S4_C.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR041982; KOW_RPS4.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR000876; Ribosomal_S4e.
DR   InterPro; IPR013845; Ribosomal_S4e_central_region.
DR   InterPro; IPR038237; Ribosomal_S4e_central_sf.
DR   InterPro; IPR013843; Ribosomal_S4e_N.
DR   InterPro; IPR018199; Ribosomal_S4e_N_CS.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR11581; PTHR11581; 1.
DR   Pfam; PF16121; 40S_S4_C; 1.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF00900; Ribosomal_S4e; 1.
DR   Pfam; PF08071; RS4NT; 1.
DR   Pfam; PF01479; S4; 1.
DR   PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR   SMART; SM00363; S4; 1.
DR   PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR   PROSITE; PS50889; S4; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; Isopeptide bond; Reference proteome;
KW   Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW   Ubl conjugation.
FT   CHAIN           1..263
FT                   /note="40S ribosomal protein S4, X isoform"
FT                   /id="PRO_0000130808"
FT   DOMAIN          42..104
FT                   /note="S4 RNA-binding"
FT   MOD_RES         233
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P62702"
FT   CROSSLNK        230
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:P62701"
SQ   SEQUENCE   263 AA;  29689 MW;  6ADBBCA7C58A15F6 CRC64;
     MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE
     VKKICMQRFI KIDGKVRTDT TYPVGFMDVI SIEKTGEHFR LVYDTKGRFA VHRITAEEAK
     YKLCKVRKTF VGTKAIPHLV THDARTIRYP DPLIKMNDTI QIDLETGKIT DFIKFDTGNM
     CMVTGGANLG RIGVITNREK HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR
     GKGIRLTIAE ERDKRLAAKQ NNG