RS4X_RAT
ID RS4X_RAT Reviewed; 263 AA.
AC P62703; P12631; P12750; P27576; P55831; Q14727;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=40S ribosomal protein S4, X isoform;
GN Name=Rps4x; Synonyms=Rps4;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver;
RX PubMed=2660908; DOI=10.1016/0167-4781(80)90019-6;
RA Devi K.R., Chan Y.-L., Wool I.G.;
RT "The primary structure of rat ribosomal protein S4.";
RL Biochim. Biophys. Acta 1008:258-262(1989).
RN [2]
RP SEQUENCE REVISION.
RX PubMed=2207170; DOI=10.1016/0167-4781(90)90143-p;
RA Wool I.G., Chan Y.-L., Paz V., Olvera J.;
RT "The primary structure of rat ribosomal proteins: the amino acid sequences
RT of L27a and L28 and corrections in the sequences of S4 and S12.";
RL Biochim. Biophys. Acta 1050:69-73(1990).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Identified in a IGF2BP1-dependent mRNP granule complex
CC containing untranslated mRNAs. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localized in
CC cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC {ECO:0000305}.
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DR EMBL; X14210; CAA32427.1; -; mRNA.
DR EMBL; BC086560; AAH86560.1; -; mRNA.
DR PIR; S14080; R3RT4.
DR RefSeq; NP_001007601.1; NM_001007600.2.
DR AlphaFoldDB; P62703; -.
DR SMR; P62703; -.
DR BioGRID; 1201774; 6.
DR IntAct; P62703; 12.
DR MINT; P62703; -.
DR STRING; 10116.ENSRNOP00000043988; -.
DR iPTMnet; P62703; -.
DR PhosphoSitePlus; P62703; -.
DR jPOST; P62703; -.
DR PaxDb; P62703; -.
DR PRIDE; P62703; -.
DR Ensembl; ENSRNOT00000051149; ENSRNOP00000043988; ENSRNOG00000029574.
DR GeneID; 100362640; -.
DR KEGG; rno:100362640; -.
DR UCSC; RGD:3600; rat.
DR CTD; 6191; -.
DR RGD; 2324318; Rps4x.
DR VEuPathDB; HostDB:ENSRNOG00000003201; -.
DR eggNOG; KOG0378; Eukaryota.
DR GeneTree; ENSGT00390000005569; -.
DR HOGENOM; CLU_060400_1_0_1; -.
DR InParanoid; P62703; -.
DR OrthoDB; 1065966at2759; -.
DR PhylomeDB; P62703; -.
DR TreeFam; TF300612; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72649; Translation initiation complex formation.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-RNO-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62703; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Bgee; ENSRNOG00000003201; Expressed in thymus and 19 other tissues.
DR ExpressionAtlas; P62703; baseline and differential.
DR Genevisible; P62703; RN.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; ISO:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; ISO:RGD.
DR GO; GO:0005844; C:polysome; ISO:RGD.
DR GO; GO:1990904; C:ribonucleoprotein complex; ISS:UniProtKB.
DR GO; GO:0005840; C:ribosome; IDA:RGD.
DR GO; GO:0015935; C:small ribosomal subunit; ISO:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0045727; P:positive regulation of translation; ISO:RGD.
DR GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR GO; GO:0006412; P:translation; ISO:RGD.
DR CDD; cd06087; KOW_RPS4; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.740; -; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR HAMAP; MF_00485; Ribosomal_S4e; 1.
DR InterPro; IPR032277; 40S_S4_C.
DR InterPro; IPR005824; KOW.
DR InterPro; IPR041982; KOW_RPS4.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR000876; Ribosomal_S4e.
DR InterPro; IPR013845; Ribosomal_S4e_central_region.
DR InterPro; IPR038237; Ribosomal_S4e_central_sf.
DR InterPro; IPR013843; Ribosomal_S4e_N.
DR InterPro; IPR018199; Ribosomal_S4e_N_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11581; PTHR11581; 1.
DR Pfam; PF16121; 40S_S4_C; 1.
DR Pfam; PF00467; KOW; 1.
DR Pfam; PF00900; Ribosomal_S4e; 1.
DR Pfam; PF08071; RS4NT; 1.
DR Pfam; PF01479; S4; 1.
DR PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR PROSITE; PS50889; S4; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Isopeptide bond; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding;
KW Ubl conjugation.
FT CHAIN 1..263
FT /note="40S ribosomal protein S4, X isoform"
FT /id="PRO_0000130810"
FT DOMAIN 42..104
FT /note="S4 RNA-binding"
FT MOD_RES 233
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62702"
FT CROSSLNK 230
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62701"
SQ SEQUENCE 263 AA; 29598 MW; 87200E545A8958B0 CRC64;
MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIIFLRN RLKYALTGDE
VKKICMQRFI KIDGKVRTDI TYPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK
YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI QIDLETGKIT DFIKFDTGNL
CMVTGGANLG RIGVITNRER HPGSFDVVHV KDANGNSFAT RLSNIFVIGK GNKPWISLPR
GKGIRLTIAE ERDKRLAAKQ SSG
