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RS4Y2_HUMAN
ID   RS4Y2_HUMAN             Reviewed;         263 AA.
AC   Q8TD47; A6NIR6;
DT   17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 152.
DE   RecName: Full=40S ribosomal protein S4, Y isoform 2;
DE   AltName: Full=Small ribosomal subunit protein eS4 {ECO:0000303|PubMed:24524803};
GN   Name=RPS4Y2; Synonyms=RPS4Y2P;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA / MRNA].
RX   PubMed=12815422; DOI=10.1038/nature01722;
RA   Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W.,
RA   Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A.,
RA   Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R.,
RA   Graves T.A., Hou S.-F., Latrielle P., Leonard S., Mardis E., Maupin R.,
RA   McPherson J., Miner T., Nash W., Nguyen C., Ozersky P., Pepin K., Rock S.,
RA   Rohlfing T., Scott K., Schultz B., Strong C., Tin-Wollam A., Yang S.-P.,
RA   Waterston R.H., Wilson R.K., Rozen S., Page D.C.;
RT   "The male-specific region of the human Y chromosome is a mosaic of discrete
RT   sequence classes.";
RL   Nature 423:825-837(2003).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=24524803; DOI=10.1016/j.sbi.2014.01.002;
RA   Ban N., Beckmann R., Cate J.H.D., Dinman J.D., Dragon F., Ellis S.R.,
RA   Lafontaine D.L.J., Lindahl L., Liljas A., Lipton J.M., McAlear M.A.,
RA   Moore P.B., Noller H.F., Ortega J., Panse V.G., Ramakrishnan V.,
RA   Spahn C.M.T., Steitz T.A., Tchorzewski M., Tollervey D., Warren A.J.,
RA   Williamson J.R., Wilson D., Yonath A., Yusupov M.;
RT   "A new system for naming ribosomal proteins.";
RL   Curr. Opin. Struct. Biol. 24:165-169(2014).
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC       {ECO:0000305}.
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DR   EMBL; AC009494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF497481; AAM18074.1; -; mRNA.
DR   CCDS; CCDS44028.1; -.
DR   RefSeq; NP_001034656.1; NM_001039567.2.
DR   AlphaFoldDB; Q8TD47; -.
DR   SMR; Q8TD47; -.
DR   BioGRID; 126595; 141.
DR   iPTMnet; Q8TD47; -.
DR   PhosphoSitePlus; Q8TD47; -.
DR   SwissPalm; Q8TD47; -.
DR   BioMuta; RPS4Y2; -.
DR   DMDM; 27805713; -.
DR   jPOST; Q8TD47; -.
DR   MassIVE; Q8TD47; -.
DR   MaxQB; Q8TD47; -.
DR   PaxDb; Q8TD47; -.
DR   PeptideAtlas; Q8TD47; -.
DR   PRIDE; Q8TD47; -.
DR   ProteomicsDB; 74240; -.
DR   TopDownProteomics; Q8TD47; -.
DR   Antibodypedia; 75451; 31 antibodies from 11 providers.
DR   DNASU; 140032; -.
DR   Ensembl; ENST00000629237.2; ENSP00000486252.1; ENSG00000280969.2.
DR   GeneID; 140032; -.
DR   KEGG; hsa:140032; -.
DR   MANE-Select; ENST00000629237.2; ENSP00000486252.1; NM_001039567.3; NP_001034656.1.
DR   UCSC; uc011nbb.3; human.
DR   CTD; 140032; -.
DR   DisGeNET; 140032; -.
DR   GeneCards; RPS4Y2; -.
DR   GeneReviews; RPS4Y2; -.
DR   HGNC; HGNC:18501; RPS4Y2.
DR   HPA; ENSG00000280969; Group enriched (prostate, testis).
DR   MalaCards; RPS4Y2; -.
DR   MIM; 400030; gene.
DR   neXtProt; NX_Q8TD47; -.
DR   OpenTargets; ENSG00000280969; -.
DR   PharmGKB; PA38563; -.
DR   VEuPathDB; HostDB:ENSG00000280969; -.
DR   GeneTree; ENSGT00390000005569; -.
DR   HOGENOM; CLU_060400_1_0_1; -.
DR   InParanoid; Q8TD47; -.
DR   OMA; ERHPGSC; -.
DR   OrthoDB; 1065966at2759; -.
DR   PhylomeDB; Q8TD47; -.
DR   TreeFam; TF300612; -.
DR   PathwayCommons; Q8TD47; -.
DR   Reactome; R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-HSA-156902; Peptide chain elongation.
DR   Reactome; R-HSA-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-HSA-192823; Viral mRNA Translation.
DR   Reactome; R-HSA-2408557; Selenocysteine synthesis.
DR   Reactome; R-HSA-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-HSA-72649; Translation initiation complex formation.
DR   Reactome; R-HSA-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-HSA-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR   Reactome; R-HSA-72702; Ribosomal scanning and start codon recognition.
DR   Reactome; R-HSA-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-HSA-72764; Eukaryotic Translation Termination.
DR   Reactome; R-HSA-9010553; Regulation of expression of SLITs and ROBOs.
DR   Reactome; R-HSA-9633012; Response of EIF2AK4 (GCN2) to amino acid deficiency.
DR   Reactome; R-HSA-9754678; SARS-CoV-2 modulates host translation machinery.
DR   Reactome; R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   SignaLink; Q8TD47; -.
DR   SIGNOR; Q8TD47; -.
DR   BioGRID-ORCS; 140032; 10 hits in 683 CRISPR screens.
DR   ChiTaRS; RPS4Y2; human.
DR   GenomeRNAi; 140032; -.
DR   Pharos; Q8TD47; Tdark.
DR   PRO; PR:Q8TD47; -.
DR   Proteomes; UP000005640; Chromosome Y.
DR   RNAct; Q8TD47; protein.
DR   Bgee; ENSG00000280969; Expressed in right testis and 15 other tissues.
DR   GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   CDD; cd06087; KOW_RPS4; 1.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.740; -; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   HAMAP; MF_00485; Ribosomal_S4e; 1.
DR   InterPro; IPR032277; 40S_S4_C.
DR   InterPro; IPR005824; KOW.
DR   InterPro; IPR041982; KOW_RPS4.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR000876; Ribosomal_S4e.
DR   InterPro; IPR013845; Ribosomal_S4e_central_region.
DR   InterPro; IPR038237; Ribosomal_S4e_central_sf.
DR   InterPro; IPR013843; Ribosomal_S4e_N.
DR   InterPro; IPR018199; Ribosomal_S4e_N_CS.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR11581; PTHR11581; 1.
DR   Pfam; PF16121; 40S_S4_C; 1.
DR   Pfam; PF00467; KOW; 1.
DR   Pfam; PF00900; Ribosomal_S4e; 1.
DR   Pfam; PF08071; RS4NT; 1.
DR   PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR   PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR   PROSITE; PS50889; S4; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW   rRNA-binding.
FT   CHAIN           1..263
FT                   /note="40S ribosomal protein S4, Y isoform 2"
FT                   /id="PRO_0000130818"
FT   DOMAIN          42..104
FT                   /note="S4 RNA-binding"
SQ   SEQUENCE   263 AA;  29295 MW;  7044C5C97361E3D0 CRC64;
     MARGPKKHLK RVAAPKHWML DKLTGVFAPR PSTGPHKLRE CLPLIVFLRN RLKYALTGDE
     VKKICMQHFL KIDGKVRVDI TYPAGFIDVI SIEKTGEHFR LVYNTKGCFA VHRITVEEAK
     YKLCKVRKIT VGTKGIPHLV THDARTIRYP DPLIKVNDTV QIDLGTGKIT SFIKFDTGNV
     CMVIAGANLG RVGVITNRER HPGSCDVVHV KDANGNSFAT RISNIFVIGN GNKPWISLPR
     GKGIRLTIAE ERDKRLAAKQ SSG
 
 
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