BAMA_HELPY
ID BAMA_HELPY Reviewed; 916 AA.
AC O25369;
DT 13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 96.
DE RecName: Full=Outer membrane protein assembly factor BamA {ECO:0000255|HAMAP-Rule:MF_01430};
DE Flags: Precursor;
GN Name=bamA {ECO:0000255|HAMAP-Rule:MF_01430}; OrderedLocusNames=HP_0655;
OS Helicobacter pylori (strain ATCC 700392 / 26695) (Campylobacter pylori).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85962;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700392 / 26695;
RX PubMed=9252185; DOI=10.1038/41483;
RA Tomb J.-F., White O., Kerlavage A.R., Clayton R.A., Sutton G.G.,
RA Fleischmann R.D., Ketchum K.A., Klenk H.-P., Gill S.R., Dougherty B.A.,
RA Nelson K.E., Quackenbush J., Zhou L., Kirkness E.F., Peterson S.N.,
RA Loftus B.J., Richardson D.L., Dodson R.J., Khalak H.G., Glodek A.,
RA McKenney K., FitzGerald L.M., Lee N., Adams M.D., Hickey E.K., Berg D.E.,
RA Gocayne J.D., Utterback T.R., Peterson J.D., Kelley J.M., Cotton M.D.,
RA Weidman J.F., Fujii C., Bowman C., Watthey L., Wallin E., Hayes W.S.,
RA Borodovsky M., Karp P.D., Smith H.O., Fraser C.M., Venter J.C.;
RT "The complete genome sequence of the gastric pathogen Helicobacter
RT pylori.";
RL Nature 388:539-547(1997).
CC -!- FUNCTION: Part of the outer membrane protein assembly complex, which is
CC involved in assembly and insertion of beta-barrel proteins into the
CC outer membrane. {ECO:0000255|HAMAP-Rule:MF_01430}.
CC -!- SUBUNIT: Part of the Bam complex. {ECO:0000255|HAMAP-Rule:MF_01430}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000255|HAMAP-
CC Rule:MF_01430}.
CC -!- SIMILARITY: Belongs to the BamA family. {ECO:0000255|HAMAP-
CC Rule:MF_01430}.
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DR EMBL; AE000511; AAD07720.1; -; Genomic_DNA.
DR PIR; G64601; G64601.
DR RefSeq; NP_207449.1; NC_000915.1.
DR RefSeq; WP_010875513.1; NC_018939.1.
DR AlphaFoldDB; O25369; -.
DR SMR; O25369; -.
DR IntAct; O25369; 13.
DR MINT; O25369; -.
DR STRING; 85962.C694_03385; -.
DR PaxDb; O25369; -.
DR PRIDE; O25369; -.
DR EnsemblBacteria; AAD07720; AAD07720; HP_0655.
DR KEGG; hpy:HP_0655; -.
DR PATRIC; fig|85962.8.peg.686; -.
DR eggNOG; COG4775; Bacteria.
DR OMA; IEWISPM; -.
DR PhylomeDB; O25369; -.
DR Proteomes; UP000000429; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043165; P:Gram-negative-bacterium-type cell outer membrane assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01430; OM_assembly_BamA; 1.
DR InterPro; IPR000184; Bac_surfAg_D15.
DR InterPro; IPR010827; BamA/TamA_POTRA.
DR InterPro; IPR039910; D15-like.
DR InterPro; IPR023707; OM_assembly_BamA.
DR InterPro; IPR034746; POTRA.
DR PANTHER; PTHR12815; PTHR12815; 1.
DR PANTHER; PTHR12815:SF23; PTHR12815:SF23; 1.
DR Pfam; PF01103; Omp85; 1.
DR Pfam; PF07244; POTRA; 5.
DR PIRSF; PIRSF006076; OM_assembly_OMP85; 1.
DR TIGRFAMs; TIGR03303; OM_YaeT; 1.
DR PROSITE; PS51779; POTRA; 5.
PE 3: Inferred from homology;
KW Cell outer membrane; Membrane; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane beta strand.
FT SIGNAL 1..20
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01430"
FT CHAIN 21..916
FT /note="Outer membrane protein assembly factor BamA"
FT /id="PRO_0000417615"
FT DOMAIN 70..137
FT /note="POTRA 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 138..214
FT /note="POTRA 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 219..309
FT /note="POTRA 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 312..391
FT /note="POTRA 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT DOMAIN 394..466
FT /note="POTRA 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01115"
FT REGION 21..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 56..70
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 916 AA; 102672 MW; 186D8E301CD9408A CRC64;
MKKLILSSLV FACINTSVEA LENDGSKPND LTSPKEASQE SQKNEAPKNE VQRNEAQKET
PQSNQTPKEM KVKSISYVGL SYMSDMLANE IVKIRVGDIV DSKKIDTAVL ALFNQGYFKD
VYATFEGGIL EFHFDEKARI AGVEIKGYGT EKEKDGLKSQ MGIKKGDTFD EQKLEHAKTA
LKTALEGQGY YGSVVEVRTE KVSEGALLIV FDVNRGDSIY IKQSIYEGSA KLKRRMIESL
SANKQRDFMG WMWGLNDGKL RLDQLEYDSM RIQDVYMRRG YLDAHISSPF LKTDFSTHDA
KLHYKVKEGI QYRISDILIE IDNPVVPLKT LEKALKVKRK DVFNIEHLRA DAQILKTEIA
DKGYAFAVVK PDLDKDEKNG LVKVIYRIEV GDMVYINDVI ISGNQRTSDR IIRRELLLGP
KDKYNLTKLR NSENSLRRLG FFSKVKIEEK RVNSSLMDLL VSVEEGRTGQ LQFGLGYGSY
GGLMLNGSVS ERNLFGTGQS MSLYANIATG GGRSYPGMPK GAGRMFAGNL SLTNPRIFDS
WYSSTINLYA DYRISYQYIQ QGGGFGVNVG RMLGNRTHVS LGYNLNVTKL LGFSSPLYNR
YYSSVNEVVS PRQCSTPASV IINRLSGGKT PLQPESCSSP GAITTSPEIR GIWDRDYHTP
ITSSFTLDVS YDNTDDYYFP RNGVIFSSYA TMSGLPSSGT LNSWNGLGGN VRNTKVYGKF
AAYHHLQKYL LIDLIARFKT QGGYIFRYNT DDYLPLNSTF YMGGVTTVRG FRNGSVTPKD
EFGLWLGGDG IFTASTELSY GVLKAAKMRL AWFFDFGFLT FKTPTRGSFF YNAPVTTANF
KDYGVIGAGF ERATWRASTG LQIEWISPMG PLVLIFPIAF FNQWGDGNGK KCKGLCFNPN
MDDYTQHFEF SMGTRF
