RS4_DICDI
ID RS4_DICDI Reviewed; 267 AA.
AC P51405; Q559A3;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 134.
DE RecName: Full=40S ribosomal protein S4;
GN Name=rps4; ORFNames=DDB_G0272825;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PROTEIN SEQUENCE OF 2-15.
RC STRAIN=AX2;
RX PubMed=9871125; DOI=10.1007/s002940050415;
RA Tapparo A., Satre M., Klein G.;
RT "Cloning, sequencing and developmental expression of the genes encoding S4
RT and S10 ribosomal proteins in the cellular slime mould Dictyostelium
RT discoideum.";
RL Curr. Genet. 34:410-418(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 195-267.
RC STRAIN=V12M2;
RA Hogan L.H.;
RT "Expression of genes encoding two ribosomal proteins, S4 and P0, during
RT growth and differentiation of Dictyostelium discoideum.";
RL Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expression drops sharply between 4 and 8 hours of
CC development and reaches a very low level at 24 hours.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC {ECO:0000305}.
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DR EMBL; AF039748; AAD04813.1; -; mRNA.
DR EMBL; AAFI02000008; EAL71050.1; -; Genomic_DNA.
DR EMBL; U15424; AAA76860.1; -; mRNA.
DR RefSeq; XP_644913.1; XM_639821.1.
DR AlphaFoldDB; P51405; -.
DR SMR; P51405; -.
DR BioGRID; 1243595; 4.
DR STRING; 44689.DDB0185063; -.
DR PaxDb; P51405; -.
DR EnsemblProtists; EAL71050; EAL71050; DDB_G0272825.
DR GeneID; 8618592; -.
DR KEGG; ddi:DDB_G0272825; -.
DR dictyBase; DDB_G0272825; rps4.
DR eggNOG; KOG0378; Eukaryota.
DR HOGENOM; CLU_060400_1_0_1; -.
DR InParanoid; P51405; -.
DR OMA; PAGFIMD; -.
DR PhylomeDB; P51405; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72695; Formation of the ternary complex, and subsequently, the 43S complex.
DR Reactome; R-DDI-72702; Ribosomal scanning and start codon recognition.
DR Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P51405; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005856; C:cytoskeleton; IDA:dictyBase.
DR GO; GO:0022627; C:cytosolic small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0032991; C:protein-containing complex; IDA:dictyBase.
DR GO; GO:0000822; F:inositol hexakisphosphate binding; IDA:dictyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IMP:dictyBase.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR CDD; cd06087; KOW_RPS4; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.740; -; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR HAMAP; MF_00485; Ribosomal_S4e; 1.
DR InterPro; IPR032277; 40S_S4_C.
DR InterPro; IPR041982; KOW_RPS4.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR000876; Ribosomal_S4e.
DR InterPro; IPR013845; Ribosomal_S4e_central_region.
DR InterPro; IPR038237; Ribosomal_S4e_central_sf.
DR InterPro; IPR013843; Ribosomal_S4e_N.
DR InterPro; IPR018199; Ribosomal_S4e_N_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11581; PTHR11581; 1.
DR Pfam; PF16121; 40S_S4_C; 1.
DR Pfam; PF00900; Ribosomal_S4e; 1.
DR Pfam; PF08071; RS4NT; 1.
DR Pfam; PF01479; S4; 1.
DR PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR PROSITE; PS00528; RIBOSOMAL_S4E; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:9871125"
FT CHAIN 2..267
FT /note="40S ribosomal protein S4"
FT /id="PRO_0000130828"
FT DOMAIN 42..104
FT /note="S4 RNA-binding"
SQ SEQUENCE 267 AA; 30036 MW; E081DFB7369E2F1A CRC64;
MARGPKKHLK RLAAPNHWML DKLSGKWAPR PSSGPHKLRE CLPLILVLRN RLKYALTKKE
VTLILMQRLV KVDGKVRTDP NYPAGFMDVI SIEKTKENFR LLFDPKGRFT LQRITPEEAK
FKLARVTRVE TGNQGIPYVH TDDGRTIRYP DPAISIHDTI KIDIESGKIT AFIPFEVNNL
CMIVGGHNLG RVGAVTHREK HPGSFDIVHV TDTAGHQFAT RLSNVFIIGK ASQTFVSLPA
GKGVRRSRVD ERNAALKRRG EKIETVA
