ID   RS4_ENCCU               Reviewed;         268 AA.
AC   Q8SRB9;
DT   01-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=40S ribosomal protein S4;
GN   Name=RPS4; OrderedLocusNames=ECU08_0870;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], AND
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16691553; DOI=10.1002/pmic.200500796;
RA   Brosson D., Kuhn L., Delbac F., Garin J., Vivares C.P., Texier C.;
RT   "Proteomic analysis of the eukaryotic parasite Encephalitozoon cuniculi
RT   (microsporidia): a reference map for proteins expressed in late sporogonial
RT   stages.";
RL   Proteomics 6:3625-3635(2006).
CC   -!- SUBUNIT: Component of the small ribosomal subunit. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in late sporogonial stages.
CC       {ECO:0000269|PubMed:16691553}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eS4 family.
CC       {ECO:0000305}.
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DR   EMBL; AL590448; CAD26393.1; -; Genomic_DNA.
DR   RefSeq; NP_597217.1; NM_001041826.1.
DR   PDB; 7QEP; EM; 2.70 A; S4=1-268.
DR   PDBsum; 7QEP; -.
DR   AlphaFoldDB; Q8SRB9; -.
DR   SMR; Q8SRB9; -.
DR   STRING; 284813.Q8SRB9; -.
DR   PRIDE; Q8SRB9; -.
DR   GeneID; 859639; -.
DR   KEGG; ecu:ECU08_0870; -.
DR   VEuPathDB; MicrosporidiaDB:ECU08_0870; -.
DR   HOGENOM; CLU_060400_1_0_1; -.
DR   InParanoid; Q8SRB9; -.
DR   OMA; FPVGLMD; -.
DR   OrthoDB; 1065966at2759; -.
DR   Proteomes; UP000000819; Chromosome VIII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.740; -; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   HAMAP; MF_00485; Ribosomal_S4e; 1.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR000876; Ribosomal_S4e.
DR   InterPro; IPR013845; Ribosomal_S4e_central_region.
DR   InterPro; IPR038237; Ribosomal_S4e_central_sf.
DR   InterPro; IPR013843; Ribosomal_S4e_N.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR11581; PTHR11581; 1.
DR   Pfam; PF00900; Ribosomal_S4e; 1.
DR   Pfam; PF08071; RS4NT; 1.
DR   PIRSF; PIRSF002116; Ribosomal_S4; 1.
DR   PROSITE; PS50889; S4; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding.
FT   CHAIN           1..268
FT                   /note="40S ribosomal protein S4"
FT                   /id="PRO_0000383137"
FT   DOMAIN          42..105
FT                   /note="S4 RNA-binding"
SQ   SEQUENCE   268 AA;  30045 MW;  D099DAF552F13688 CRC64;
     MPTGHRDHLK RKTAPKSWML DKQGGTFALM PASGPHKKTE CIPLGYLISR FLRYASNFKE
     LSIILAEKNI KVNGRVRTNS HFPVGLFDVV SIEKTGEHFR VLYNVHKKFH LHRISSEEAS
     YRLTKVTKKY ENQGIPYIVS SCGLSIRFCD PAIDLGYTIK ISNETSKVIE YIVPGPDKVI
     FVSRGKARGR VGVINTISTQ GKETVYGMTD FAGNTFSCTS KSCILIGESS ENIWITLPKE
     RGIRQSELEK INAQLGEMID TEVAEVSE