ID   RS4_ENTFA               Reviewed;         203 AA.
AC   Q82ZI6;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=30S ribosomal protein S4 {ECO:0000255|HAMAP-Rule:MF_01306};
GN   Name=rpsD {ECO:0000255|HAMAP-Rule:MF_01306}; OrderedLocusNames=EF_3070;
OS   Enterococcus faecalis (strain ATCC 700802 / V583).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Enterococcaceae;
OC   Enterococcus.
OX   NCBI_TaxID=226185;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700802 / V583;
RX   PubMed=12663927; DOI=10.1126/science.1080613;
RA   Paulsen I.T., Banerjei L., Myers G.S.A., Nelson K.E., Seshadri R.,
RA   Read T.D., Fouts D.E., Eisen J.A., Gill S.R., Heidelberg J.F., Tettelin H.,
RA   Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C.,
RA   DeBoy R.T., Durkin S.A., Kolonay J.F., Madupu R., Nelson W.C.,
RA   Vamathevan J.J., Tran B., Upton J., Hansen T., Shetty J., Khouri H.M.,
RA   Utterback T.R., Radune D., Ketchum K.A., Dougherty B.A., Fraser C.M.;
RT   "Role of mobile DNA in the evolution of vancomycin-resistant Enterococcus
RT   faecalis.";
RL   Science 299:2071-2074(2003).
CC   -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC       to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
CC       {ECO:0000255|HAMAP-Rule:MF_01306}.
CC   -!- FUNCTION: With S5 and S12 plays an important role in translational
CC       accuracy. {ECO:0000255|HAMAP-Rule:MF_01306}.
CC   -!- SUBUNIT: Part of the 30S ribosomal subunit. Contacts protein S5. The
CC       interaction surface between S4 and S5 is involved in control of
CC       translational fidelity. {ECO:0000255|HAMAP-Rule:MF_01306}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC       {ECO:0000255|HAMAP-Rule:MF_01306}.
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DR   EMBL; AE016830; AAO82752.1; -; Genomic_DNA.
DR   RefSeq; NP_816682.1; NC_004668.1.
DR   RefSeq; WP_002365342.1; NZ_KE136524.1.
DR   PDB; 6WUB; EM; 3.20 A; d=2-202.
DR   PDB; 7P7R; EM; 2.90 A; e=1-203.
DR   PDBsum; 6WUB; -.
DR   PDBsum; 7P7R; -.
DR   AlphaFoldDB; Q82ZI6; -.
DR   SMR; Q82ZI6; -.
DR   STRING; 226185.EF_3070; -.
DR   EnsemblBacteria; AAO82752; AAO82752; EF_3070.
DR   GeneID; 60894959; -.
DR   KEGG; efa:EF3070; -.
DR   PATRIC; fig|226185.45.peg.501; -.
DR   eggNOG; COG0522; Bacteria.
DR   HOGENOM; CLU_092403_0_1_9; -.
DR   OMA; NVVFRMG; -.
DR   Proteomes; UP000001415; Chromosome.
DR   GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR   CDD; cd00165; S4; 1.
DR   Gene3D; 3.10.290.10; -; 1.
DR   HAMAP; MF_01306_B; Ribosomal_S4_B; 1.
DR   InterPro; IPR022801; Ribosomal_S4/S9.
DR   InterPro; IPR001912; Ribosomal_S4/S9_N.
DR   InterPro; IPR005709; Ribosomal_S4_bac-type.
DR   InterPro; IPR018079; Ribosomal_S4_CS.
DR   InterPro; IPR002942; S4_RNA-bd.
DR   InterPro; IPR036986; S4_RNA-bd_sf.
DR   PANTHER; PTHR11831; PTHR11831; 1.
DR   PANTHER; PTHR11831:SF4; PTHR11831:SF4; 1.
DR   Pfam; PF00163; Ribosomal_S4; 1.
DR   Pfam; PF01479; S4; 1.
DR   SMART; SM01390; Ribosomal_S4; 1.
DR   SMART; SM00363; S4; 1.
DR   TIGRFAMs; TIGR01017; rpsD_bact; 1.
DR   PROSITE; PS00632; RIBOSOMAL_S4; 1.
DR   PROSITE; PS50889; S4; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   CHAIN           1..203
FT                   /note="30S ribosomal protein S4"
FT                   /id="PRO_0000132383"
FT   DOMAIN          93..156
FT                   /note="S4 RNA-binding"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01306"
FT   REGION          22..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   HELIX           10..15
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   STRAND          25..28
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   STRAND          37..39
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           46..60
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           65..75
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           84..90
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           91..93
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           95..102
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           108..116
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           150..157
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   STRAND          164..169
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   TURN            170..173
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   STRAND          174..179
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           183..185
FT                   /evidence="ECO:0007829|PDB:6WUB"
FT   HELIX           194..198
FT                   /evidence="ECO:0007829|PDB:6WUB"
SQ   SEQUENCE   203 AA;  23234 MW;  E372215A9EE50093 CRC64;
     MSRYTGPSWK VSRRLGISLS GTGKELARRP YKPGQHGPNS RGKVSEYGMQ LTEKQKLRHM
     YGMNERQFRT LFIKASKIKE GKHGVNFMVL LEQRLDNVVY RLGLATTRRQ ARQLVNHGHI
     TVDGKRVDIP SYHVEVGQVI GVREKSQNIS TIKEAVEATV GRPAFVSFDT EKLEGSFTRL
     PERDELYPEI DEALVVEYYN QKL