RS4_HALSA
ID RS4_HALSA Reviewed; 170 AA.
AC Q9HQJ6; Q9V2W3;
DT 06-DEC-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 110.
DE RecName: Full=30S ribosomal protein S4 {ECO:0000255|HAMAP-Rule:MF_01306};
GN Name=rps4 {ECO:0000255|HAMAP-Rule:MF_01306}; OrderedLocusNames=VNG_1133G;
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium.
OX NCBI_TaxID=64091;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=R1 / S9;
RX PubMed=10527834; DOI=10.1006/bbrc.1999.1480;
RA Sano K., Taguchi A., Furumoto H., Uda T., Itoh T.;
RT "Cloning, sequencing, and characterization of ribosomal protein and RNA
RT polymerase genes from the region analogous to the alpha-operon of
RT Escherichia coli in halophilic archaea, Halobacterium halobium.";
RL Biochem. Biophys. Res. Commun. 264:24-28(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
CC -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
CC {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- FUNCTION: With S5 and S12 plays an important role in translational
CC accuracy. {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit. Contacts protein S5. The
CC interaction surface between S4 and S5 is involved in control of
CC translational fidelity. {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000255|HAMAP-Rule:MF_01306}.
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DR EMBL; AB030282; BAA85896.1; -; Genomic_DNA.
DR EMBL; AE004437; AAG19518.1; -; Genomic_DNA.
DR PIR; B84269; B84269.
DR PIR; T43938; T43938.
DR RefSeq; WP_010902813.1; NC_002607.1.
DR AlphaFoldDB; Q9HQJ6; -.
DR SMR; Q9HQJ6; -.
DR STRING; 64091.VNG_1133G; -.
DR PaxDb; Q9HQJ6; -.
DR EnsemblBacteria; AAG19518; AAG19518; VNG_1133G.
DR GeneID; 5954261; -.
DR KEGG; hal:VNG_1133G; -.
DR PATRIC; fig|64091.14.peg.864; -.
DR HOGENOM; CLU_089738_1_1_2; -.
DR InParanoid; Q9HQJ6; -.
DR OMA; ARQFITH; -.
DR OrthoDB; 93256at2157; -.
DR PhylomeDB; Q9HQJ6; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0015935; C:small ribosomal subunit; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0045903; P:positive regulation of translational fidelity; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR HAMAP; MF_01306_A; Ribosomal_S4_A; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR005710; Ribosomal_S4/S9_euk/arc.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR022802; Ribosomal_S4_arc.
DR InterPro; IPR018079; Ribosomal_S4_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR TIGRFAMs; TIGR01018; uS4_arch; 1.
DR PROSITE; PS00632; RIBOSOMAL_S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding;
KW rRNA-binding.
FT CHAIN 1..170
FT /note="30S ribosomal protein S4"
FT /id="PRO_0000132506"
FT DOMAIN 100..164
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01306"
FT CONFLICT 55..57
FT /note="ARR -> RQ (in Ref. 1; BAA85896)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 170 AA; 19323 MW; 923285FB7A2AABAC CRC64;
MALPGENTKF YETPNHPYQG ERIAEESDLL SRYGLKNKEE LWRAQSELRD YRREARRLLG
QTGTVSGEEF VARLQRIGIL SEEERLDDVL SLEVTDVLER RLQTVVYREG LANTMGQARQ
FVSHGHVTVD GSRVTEPSYT VPVSEENTLA FDETSDLTDE LHPARAGAQE
