RS4_MYCBO
ID RS4_MYCBO Reviewed; 201 AA.
AC P45811; A0A1R3Y5X1; X2BNV6;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 25-MAY-2022, entry version 124.
DE RecName: Full=30S ribosomal protein S4;
GN Name=rpsD; OrderedLocusNames=BQ2027_MB3487C;
OS Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=233413;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=12788972; DOI=10.1073/pnas.1130426100;
RA Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M.,
RA Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B.,
RA Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J.,
RA Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
RT "The complete genome sequence of Mycobacterium bovis.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=ATCC BAA-935 / AF2122/97;
RX PubMed=28385856; DOI=10.1128/genomea.00157-17;
RA Malone K.M., Farrell D., Stuber T.P., Schubert O.T., Aebersold R.,
RA Robbe-Austerman S., Gordon S.V.;
RT "Updated reference genome sequence and annotation of Mycobacterium bovis
RT AF2122/97.";
RL Genome Announc. 5:E00157-E00157(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-132.
RC STRAIN=BCG;
RX PubMed=8621083; DOI=10.1016/0378-1119(95)00841-1;
RA Dubnau E., Soares S., Huang T.J., Jacobs W.R. Jr.;
RT "Overproduction of mycobacterial ribosomal protein S13 induces
RT catalase/peroxidase activity and hypersensitivity to isoniazid in
RT Mycobacterium smegmatis.";
RL Gene 170:17-22(1996).
RN [4]
RP PROTEIN SEQUENCE OF 2-5.
RC STRAIN=BCG;
RX PubMed=8405418; DOI=10.1016/0014-5793(93)80287-5;
RA Ohara N., Kimura M., Higashi Y., Yamada T.;
RT "Isolation and amino acid sequence of the 30S ribosomal protein S19 from
RT Mycobacterium bovis BCG.";
RL FEBS Lett. 331:9-14(1993).
CC -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
CC {ECO:0000250}.
CC -!- FUNCTION: With S5 and S12 plays an important role in translational
CC accuracy. {ECO:0000250}.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit. Contacts protein S5. The
CC interaction surface between S4 and S5 is involved in control of
CC translational fidelity (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000305}.
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DR EMBL; LT708304; SIU02115.1; -; Genomic_DNA.
DR EMBL; U15140; AAB17600.1; -; Genomic_DNA.
DR RefSeq; NP_857127.1; NC_002945.3.
DR RefSeq; WP_003418354.1; NC_002945.4.
DR AlphaFoldDB; P45811; -.
DR SMR; P45811; -.
DR EnsemblBacteria; SIU02115; SIU02115; BQ2027_MB3487C.
DR GeneID; 45427447; -.
DR PATRIC; fig|233413.5.peg.3824; -.
DR OMA; NVVFRMG; -.
DR Proteomes; UP000001419; Chromosome.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR HAMAP; MF_01306_B; Ribosomal_S4_B; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR005709; Ribosomal_S4_bac-type.
DR InterPro; IPR018079; Ribosomal_S4_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR PANTHER; PTHR11831:SF4; PTHR11831:SF4; 1.
DR Pfam; PF00163; Ribosomal_S4; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR TIGRFAMs; TIGR01017; rpsD_bact; 1.
DR PROSITE; PS00632; RIBOSOMAL_S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:8405418"
FT CHAIN 2..201
FT /note="30S ribosomal protein S4"
FT /id="PRO_0000132411"
FT DOMAIN 91..157
FT /note="S4 RNA-binding"
SQ SEQUENCE 201 AA; 23476 MW; 013594A411325FD5 CRC64;
MARYTGPVTR KSRRLRTDLV GGDQAFEKRP YPPGQHGRAR IKESEYLLQL QEKQKARFTY
GVMEKQFRRY YEEAVRQPGK TGEELLKILE SRLDNVIYRA GLARTRRMAR QLVSHGHFNV
NGVHVNVPSY RVSQYDIVDV RDKSLNTVPF QIARETAGER PIPSWLQVVG ERQRVLIHQL
PERAQIDVPL TEQLIVEYYS K