RS4_PYRFU
ID RS4_PYRFU Reviewed; 180 AA.
AC P61993; Q9V199;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=30S ribosomal protein S4 {ECO:0000255|HAMAP-Rule:MF_01306};
DE AltName: Full=Small ribosomal subunit protein uS4;
GN Name=rps4 {ECO:0000255|HAMAP-Rule:MF_01306}; OrderedLocusNames=PF1649;
OS Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1).
OC Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC Pyrococcus.
OX NCBI_TaxID=186497;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43587 / DSM 3638 / JCM 8422 / Vc1;
RX PubMed=10430560; DOI=10.1093/genetics/152.4.1299;
RA Maeder D.L., Weiss R.B., Dunn D.M., Cherry J.L., Gonzalez J.M.,
RA DiRuggiero J., Robb F.T.;
RT "Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P.
RT horikoshii inferred from complete genomic sequences.";
RL Genetics 152:1299-1305(1999).
RN [2] {ECO:0007744|PDB:4V6U}
RP STRUCTURE BY ELECTRON MICROSCOPY (6.60 ANGSTROMS) IN THE 70S RIBOSOME, AND
RP SUBUNIT.
RX PubMed=23222135; DOI=10.1093/nar/gks1259;
RA Armache J.P., Anger A.M., Marquez V., Franckenberg S., Frohlich T.,
RA Villa E., Berninghausen O., Thomm M., Arnold G.J., Beckmann R.,
RA Wilson D.N.;
RT "Promiscuous behaviour of archaeal ribosomal proteins: implications for
RT eukaryotic ribosome evolution.";
RL Nucleic Acids Res. 41:1284-1293(2013).
CC -!- FUNCTION: One of the primary rRNA binding proteins, it binds directly
CC to 16S rRNA where it nucleates assembly of the body of the 30S subunit.
CC {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- FUNCTION: With S5 and S12 plays an important role in translational
CC accuracy. {ECO:0000255|HAMAP-Rule:MF_01306}.
CC -!- SUBUNIT: Part of the 30S ribosomal subunit (PubMed:23222135). Contacts
CC protein S5. The interaction surface between S4 and S5 is involved in
CC control of translational fidelity. {ECO:0000255|HAMAP-Rule:MF_01306,
CC ECO:0000269|PubMed:23222135}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uS4 family.
CC {ECO:0000255|HAMAP-Rule:MF_01306}.
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DR EMBL; AE009950; AAL81773.1; -; Genomic_DNA.
DR RefSeq; WP_010867652.1; NZ_CP023154.1.
DR PDB; 4V6U; EM; 6.60 A; AD=1-180.
DR PDBsum; 4V6U; -.
DR AlphaFoldDB; P61993; -.
DR SMR; P61993; -.
DR STRING; 186497.PF1649; -.
DR EnsemblBacteria; AAL81773; AAL81773; PF1649.
DR GeneID; 41713476; -.
DR KEGG; pfu:PF1649; -.
DR PATRIC; fig|186497.12.peg.1715; -.
DR eggNOG; arCOG04239; Archaea.
DR HOGENOM; CLU_089738_1_1_2; -.
DR OMA; ARQFITH; -.
DR OrthoDB; 93256at2157; -.
DR PhylomeDB; P61993; -.
DR Proteomes; UP000001013; Chromosome.
DR GO; GO:0015935; C:small ribosomal subunit; IEA:InterPro.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; -; 1.
DR HAMAP; MF_01306_A; Ribosomal_S4_A; 1.
DR InterPro; IPR022801; Ribosomal_S4/S9.
DR InterPro; IPR005710; Ribosomal_S4/S9_euk/arc.
DR InterPro; IPR001912; Ribosomal_S4/S9_N.
DR InterPro; IPR022802; Ribosomal_S4_arc.
DR InterPro; IPR018079; Ribosomal_S4_CS.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR PANTHER; PTHR11831; PTHR11831; 1.
DR Pfam; PF01479; S4; 1.
DR SMART; SM01390; Ribosomal_S4; 1.
DR SMART; SM00363; S4; 1.
DR TIGRFAMs; TIGR01018; uS4_arch; 1.
DR PROSITE; PS00632; RIBOSOMAL_S4; 1.
DR PROSITE; PS50889; S4; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..180
FT /note="30S ribosomal protein S4"
FT /id="PRO_0000132517"
FT DOMAIN 103..174
FT /note="S4 RNA-binding"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01306"
SQ SEQUENCE 180 AA; 21338 MW; D59E61EF49F6CE57 CRC64;
MGDPKRQRKK YETPPHPWIK ERLDRERVLM DKYELKNKKE LWKHETQLKN FRRRARRLLA
ARGKQAEIER EQLLARLKRL GLLPEDAVLD DVLSLTIEDI LERRLQTIVY KKGLARTMRQ
ARQLIVHGHI EVNGQIIRSP SYLVLKEEED TITYARTSPF ANPQHPERMM IEKAKQGGEA
